Effects of corticosterone on the secretion of corticotrophin-releasing factor, arginine vasopressin and oxytocin into hypophysial portal blood in long-term hypophysectomized rats.

Sheward WJ, Fink G

The Journal of endocrinology1 Apr 1991Cited by 14 (Europe PMC)

PMID2030334DOI10.1677/joe.0.1290091PepBankPUB-02030334

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Natural levels measured3

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

01AnimalEndogenous levelAnimal study (in vivo)Other
In urethane-anaesthetized rats, long-term hypophysectomy increased secretion of the body's own oxytocin compared with pituitary-intact rats.
In plain wordsIn rats, removing the pituitary gland for a long time raised the body's own oxytocin release.
Peptide
Oxytocin
Outcome
IncreaseOxytocin secretion after long-term hypophysectomy
Study
ratn: not reported in source
long-term hypophysectomized rats, hypophysial portal blood
Comparator
Pituitary-intact rats
Outcome group
Endogenous peptide levels · Endocrine and hormones
Source sentences
Summary
In preliminary experiments in rats anaesthetized with urethane, long-term hypophysectomy resulted in a significant increase in the secretion of oxytocin and AVP
1 context sentence(design, population, supporting numbers)
Summary · context
To investigate the feedback effects of corticosterone on the secretion of corticotrophin-releasing factor-41 (CRF-41), oxytocin and arginine vasopressin (AVP), hypophysial portal vessel blood was collected from control (intact) and long-term (6-8 weeks) hypophysectomized rats.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0203033401
02AnimalEndogenous levelAnimal study (in vivo)Other
In rats, long-term hypophysectomy increased the hypothalamic content of the body's own oxytocin compared with pituitary-intact rats.
In plain wordsIn rats, long-term pituitary removal raised the natural oxytocin stored in the hypothalamus.
Peptide
Oxytocin
Outcome
IncreaseHypothalamic oxytocin content after long-term hypophysectomy
Study
ratn: not reported in source
long-term hypophysectomized rats, hypophysial portal blood
Comparator
Pituitary-intact rats
Outcome group
Endogenous peptide levels · Endocrine and hormones
Source sentences
Summary
the hypothalamic contents of oxytocin and AVP were also increased in comparison with pituitary-intact rats
1 context sentence(design, population, supporting numbers)
Summary · context
To investigate the feedback effects of corticosterone on the secretion of corticotrophin-releasing factor-41 (CRF-41), oxytocin and arginine vasopressin (AVP), hypophysial portal vessel blood was collected from control (intact) and long-term (6-8 weeks) hypophysectomized rats.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0203033402
03AnimalEndogenous levelAnimal study (in vivo)Other
In hypophysectomized rats, a 2 h corticosterone infusion did not change the secretion of the body's own oxytocin into portal blood.
In plain wordsIn rats, a short corticosterone infusion did not change the body's own oxytocin release.
Peptide
Oxytocin
Outcome
No significant changeOxytocin secretion into portal blood during corticosterone infusion
Study
ratn: not reported in source
long-term hypophysectomized rats, hypophysial portal blood
Outcome group
Endogenous peptide levels · Endocrine and hormones
Source sentences
Summary
In long-term hypophysectomized rats anaesthetized with pentobarbitone, the i.v. infusion of corticosterone (7.2 nmol/min) for a 2 h period of portal blood collection did not alter the secretion of CRF-41, oxytocin or AVP into portal blood
1 context sentence(design, population, supporting numbers)
Summary · context
To investigate the feedback effects of corticosterone on the secretion of corticotrophin-releasing factor-41 (CRF-41), oxytocin and arginine vasopressin (AVP), hypophysial portal vessel blood was collected from control (intact) and long-term (6-8 weeks) hypophysectomized rats.
This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0203033403

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
11 Oct 2026, 20:03 UTC
Study results updated
Version 1
9 Oct 2026, 02:52 UTC
First added · source update from Europe PMC

Subjects

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