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Study · Animal study (in vivo) · rat · 1991

3 results

Influence of oxytocin on sodium excretion in the anaesthetized Brattleboro rat.

Brimble MJ, Balment RJ, Smith CP, Windle RJ, Forsling ML

The Journal of endocrinology1 Apr 1991Cited by 31 (Europe PMC)

PMID2030328 (opens in a new tab)DOI10.1677/joe.0.1290049 (opens in a new tab)PepBankPUB-02030328
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In neurohypophysectomized Brattleboro rats, oxytocin replacement to intact plasma levels produced a substantial and sustained increase in renal sodium excretion.

    In plain wordsIn rats, giving oxytocin back after pituitary removal caused a lasting rise in sodium loss in urine.

    Peptide
    Oxytocin
    Outcome
    IncreaseRenal Na+ excretion after oxytocin replacement
    Study

    ratn: not reported in source

    Brattleboro rat, anaesthetized, hypotonic saline infusion
    Comparator
    Neurohypophysectomized rats before replacement
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Oxytocin replacement to achieve plasma levels equivalent to those in intact Brattleboro rats produced a substantial and sustained natriuresis in the neurohypophysectomized animal.
    1 context sentence
    Summary · context
    The contribution of oxytocin to the maintenance of renal Na+ excretion in the Brattleboro rat has been examined in animals infused with hypotonic saline.

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 02AnimalEndogenous levelAnimal study (in vivo)Other

    Brattleboro rats had greatly increased plasma concentrations of the body's own oxytocin compared with Long-Evans control rats.

    In plain wordsIn rats, Brattleboro rats had much higher natural oxytocin levels in blood than control rats.

    Peptide
    Oxytocin
    Outcome
    IncreasePlasma oxytocin in Brattleboro rats versus control
    Study

    ratn: not reported in source

    Brattleboro rat, anaesthetized, hypotonic saline infusion
    Comparator
    Long-Evans control rats
    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Source sentences

    Summary
    Brattleboro rats exhibited hypernatraemia and hyperosmolality associated with greatly increased plasma concentrations of oxytocin by comparison with Long-Evans control rats.
    1 context sentence
    Summary · context
    The contribution of oxytocin to the maintenance of renal Na+ excretion in the Brattleboro rat has been examined in animals infused with hypotonic saline.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

Studies that did not test the peptide alone1

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

  1. 03AnimalNot a test of Oxytocin aloneAnimal study (in vivo)Efficacy outcome

    In Brattleboro rats, neurohypophysectomy, which removes remaining posterior pituitary secretion, led to greatly diminished renal sodium excretion; the effect is of the surgery, not of given oxytocin.

    In plain wordsIn rats, removing the pituitary gland sharply lowered sodium loss in urine.

    Peptide
    Oxytocin
    Outcome
    DecreaseRenal Na+ excretion after neurohypophysectomy
    Study

    ratn: not reported in source

    Brattleboro rat, anaesthetized, hypotonic saline infusion
    Outcome group
    Kidney function · Kidney and urinary

    Source sentences

    Summary
    Neurohypophysectomy to remove the secretion of the remaining posterior pituitary peptide, oxytocin, led to greatly diminished rates of Na+ excretion in the Brattleboro rat.
    1 context sentence
    Summary · context
    The contribution of oxytocin to the maintenance of renal Na+ excretion in the Brattleboro rat has been examined in animals infused with hypotonic saline.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:51 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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