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Study · Non-randomized trial · n = 24 · 1991

9 results

Growth hormone treatment in growth hormone-deficient adults. II. Effects on exercise performance.

Cuneo RC, Salomon F, Wiles CM, Hesp R, Sönksen PH

Journal of applied physiology (Bethesda, Md. : 1985)1 Feb 1991Cited by 181 (Europe PMC)

PMID2022561 (opens in a new tab)DOI10.1152/jappl.1991.70.2.695 (opens in a new tab)PepBankPUB-02022561
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. 9 results from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In GH-deficient adults, rhGH increased maximal oxygen uptake more than placebo.

    In plain wordsIn GH-deficient adults, rhGH increased maximum oxygen uptake more than placebo.

    Peptide
    HGH (somatotropin)
    Outcome
    IncreaseMaximal oxygen uptake
    Study

    n = 24

    Comparator
    Placebo
    Outcome group
    Exercise and physical function · Musculoskeletal
    Studied dose
    0.07 U/kg body wt daily · 6 moAs given in this study (human).

    Measurements

    VO2max change
    406 ml/min
    rhGH
    VO2max change
    133 ml/min
    placebo

    Source sentences

    Summary
    Compared with placebo, the rhGH group increased mean maximal O2 uptake (VO2max) (+406 +/- 71 vs. +133 +/- 84 ml/min; P = 0.016) and maximal power output (+24.6 +/- 4.3 vs. +9.7 +/- 4.8 W; P = 0.047), without differences in maximal heart rate or ventilation.
    1 context sentence
    Summary · context
    The functional significance of this was examined by incremental cycle ergometry in 24 GH-deficient adults treated in a double-blind placebo-controlled trial with recombinant DNA human GH (rhGH) for 6 mo (0.07 U/kg body wt daily).
  2. 02HumanNon-randomized trialEfficacy outcome

    In GH-deficient adults, rhGH increased maximal power output more than placebo.

    In plain wordsIn GH-deficient adults, rhGH increased maximum exercise power more than placebo.

    Peptide
    HGH (somatotropin)
    Outcome
    IncreaseMaximal power output
    Study

    n = 24

    Comparator
    Placebo
    Outcome group
    Exercise and physical function · Musculoskeletal
    Studied dose
    0.07 U/kg body wt daily · 6 moAs given in this study (human).

    Measurements

    Power change
    24.6 W
    rhGH
    Power change
    9.7 W
    placebo

    Source sentences

    Summary
    Compared with placebo, the rhGH group increased mean maximal O2 uptake (VO2max) (+406 +/- 71 vs. +133 +/- 84 ml/min; P = 0.016) and maximal power output (+24.6 +/- 4.3 vs. +9.7 +/- 4.8 W; P = 0.047), without differences in maximal heart rate or ventilation.
    1 context sentence
    Summary · context
    The functional significance of this was examined by incremental cycle ergometry in 24 GH-deficient adults treated in a double-blind placebo-controlled trial with recombinant DNA human GH (rhGH) for 6 mo (0.07 U/kg body wt daily).
  3. 03HumanNon-randomized trialEfficacy outcome

    In GH-deficient adults, maximal heart rate did not differ between rhGH and placebo.

    In plain wordsIn GH-deficient adults, maximum heart rate did not differ between rhGH and placebo.

    Peptide
    HGH (somatotropin)
    Outcome
    No significant changeMaximal heart rate
    Study

    n = 24

    Comparator
    Placebo
    Outcome group
    Exercise and physical function · Cardiovascular
    Studied dose
    0.07 U/kg body wt daily · 6 moAs given in this study (human).

    Source sentences

    Summary
    Compared with placebo, the rhGH group increased mean maximal O2 uptake (VO2max) (+406 +/- 71 vs. +133 +/- 84 ml/min; P = 0.016) and maximal power output (+24.6 +/- 4.3 vs. +9.7 +/- 4.8 W; P = 0.047), without differences in maximal heart rate or ventilation.
    1 context sentence
    Summary · context
    The functional significance of this was examined by incremental cycle ergometry in 24 GH-deficient adults treated in a double-blind placebo-controlled trial with recombinant DNA human GH (rhGH) for 6 mo (0.07 U/kg body wt daily).
  4. 04HumanNon-randomized trialEfficacy outcome

    In GH-deficient adults, maximal ventilation did not differ between rhGH and placebo.

    In plain wordsIn GH-deficient adults, maximum ventilation did not differ between rhGH and placebo.

    Peptide
    HGH (somatotropin)
    Outcome
    No significant changeMaximal ventilation
    Study

    n = 24

    Comparator
    Placebo
    Outcome group
    Exercise and physical function · Respiratory
    Studied dose
    0.07 U/kg body wt daily · 6 moAs given in this study (human).

    Source sentences

    Summary
    Compared with placebo, the rhGH group increased mean maximal O2 uptake (VO2max) (+406 +/- 71 vs. +133 +/- 84 ml/min; P = 0.016) and maximal power output (+24.6 +/- 4.3 vs. +9.7 +/- 4.8 W; P = 0.047), without differences in maximal heart rate or ventilation.
    1 context sentence
    Summary · context
    The functional significance of this was examined by incremental cycle ergometry in 24 GH-deficient adults treated in a double-blind placebo-controlled trial with recombinant DNA human GH (rhGH) for 6 mo (0.07 U/kg body wt daily).
  5. 05HumanNon-randomized trialEfficacy outcome

    In GH-deficient adults, percent predicted VO2max increased from 78.9 to 96.0% with rhGH compared with 78.5 to 85.0% with placebo.

    In plain wordsIn GH-deficient adults, rhGH increased oxygen uptake relative to predicted values more than placebo.

    Peptide
    HGH (somatotropin)
    Outcome
    IncreasePercent predicted VO2max
    Study

    n = 24

    Comparator
    Placebo
    Outcome group
    Exercise and physical function · Musculoskeletal
    Studied dose
    0.07 U/kg body wt daily · 6 moAs given in this study (human).

    Measurements

    Predicted VO2max
    78.9%
    rhGH baseline
    Predicted VO2max
    96%
    rhGH after treatment
    Predicted VO2max
    78.5%
    placebo baseline
    Predicted VO2max
    85%
    placebo after treatment

    Source sentences

    Summary
    Mean predicted VO2max, based on height and age, increased from 78.9 to 96.0% in the rhGH group (compared with 78.5 and 85.0% for placebo; P = 0.036).
    1 context sentence
    Summary · context
    The functional significance of this was examined by incremental cycle ergometry in 24 GH-deficient adults treated in a double-blind placebo-controlled trial with recombinant DNA human GH (rhGH) for 6 mo (0.07 U/kg body wt daily).
  6. 06HumanNon-randomized trialEfficacy outcome

    In GH-deficient adults, rhGH increased anaerobic ventilatory threshold more than placebo.

    In plain wordsIn GH-deficient adults, rhGH increased anaerobic ventilatory threshold more than placebo.

    Peptide
    HGH (somatotropin)
    Outcome
    IncreaseAnaerobic ventilatory threshold
    Study

    n = 24

    Comparator
    Placebo
    Outcome group
    Exercise and physical function · Musculoskeletal
    Studied dose
    0.07 U/kg body wt daily · 6 moAs given in this study (human).

    Measurements

    Threshold change
    159 ml/min
    rhGH
    Threshold change
    1 ml/min
    placebo

    Source sentences

    Summary
    The anaerobic ventilatory threshold increased in the rhGH group (+159 +/- 39 vs. +1 +/- 51 ml/min; P = 0.02).
    1 context sentence
    Summary · context
    The functional significance of this was examined by incremental cycle ergometry in 24 GH-deficient adults treated in a double-blind placebo-controlled trial with recombinant DNA human GH (rhGH) for 6 mo (0.07 U/kg body wt daily).
  7. 07HumanNon-randomized trialEfficacy outcome

    In GH-deficient adults, VO2max improvement with rhGH remained when expressed per kilogram body weight.

    In plain wordsIn GH-deficient adults, rhGH improved oxygen uptake per kilogram of body weight compared with placebo.

    Peptide
    HGH (somatotropin)
    Outcome
    IncreaseVO2max per kilogram body weight
    Study

    n = 24

    Comparator
    Placebo
    Outcome group
    Exercise and physical function · Musculoskeletal
    Studied dose
    0.07 U/kg body wt daily · 6 moAs given in this study (human).

    Source sentences

    Summary
    The improvement in VO2max was noted when expressed per kilogram body weight but not lean body mass or thigh muscle area.
    2 context sentences
    Summary · context
    Compared with placebo, the rhGH group increased mean maximal O2 uptake (VO2max) (+406 +/- 71 vs. +133 +/- 84 ml/min; P = 0.016) and maximal power output (+24.6 +/- 4.3 vs. +9.7 +/- 4.8 W; P = 0.047), without differences in maximal heart rate or ventilation.
    Summary · context
    The functional significance of this was examined by incremental cycle ergometry in 24 GH-deficient adults treated in a double-blind placebo-controlled trial with recombinant DNA human GH (rhGH) for 6 mo (0.07 U/kg body wt daily).
  8. 08HumanNon-randomized trialEfficacy outcome

    In GH-deficient adults, VO2max improvement with rhGH did not remain after normalization to lean body mass or thigh muscle area.

    In plain wordsIn GH-deficient adults, oxygen uptake improvement versus placebo did not remain after adjustment for lean mass or thigh muscle area.

    Peptide
    HGH (somatotropin)
    Outcome
    No significant changeVO2max normalized to lean mass or thigh muscle area
    Study

    n = 24

    Comparator
    Placebo
    Outcome group
    Exercise and physical function · Musculoskeletal
    Studied dose
    0.07 U/kg body wt daily · 6 moAs given in this study (human).

    Source sentences

    Summary
    The improvement in VO2max was noted when expressed per kilogram body weight but not lean body mass or thigh muscle area.
    1 context sentence
    Summary · context
    The functional significance of this was examined by incremental cycle ergometry in 24 GH-deficient adults treated in a double-blind placebo-controlled trial with recombinant DNA human GH (rhGH) for 6 mo (0.07 U/kg body wt daily).
  9. 09HumanNon-randomized trialEfficacy outcome

    In GH-deficient adults, forced expiratory volume, vital capacity, and corrected CO gas transfer did not change with rhGH.

    In plain wordsIn GH-deficient adults, three lung function measures did not change during rhGH treatment.

    Peptide
    HGH (somatotropin)
    Outcome
    No significant changePulmonary function measures
    Study

    n: not reported in source

    Outcome group
    Exercise and physical function · Respiratory
    Studied dose
    0.07 U/kg body wt daily · 6 moAs given in this study (human).

    Source sentences

    Summary
    Forced expiratory volume in 1 s, vital capacity, and corrected CO gas transfer were within normal limits and did not change with treatment.
    1 context sentence
    Summary · context
    The functional significance of this was examined by incremental cycle ergometry in 24 GH-deficient adults treated in a double-blind placebo-controlled trial with recombinant DNA human GH (rhGH) for 6 mo (0.07 U/kg body wt daily).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:37 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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