In children with nephrosis, added salmon calcitonin preserved cortical vertebral mineral content, while the vitamin D3-only control group lost mineral content significantly.
In plain wordsIn children with nephrosis, added salmon calcitonin preserved cortical vertebral mineral content compared with vitamin D3 alone.
- Peptide
- Calcitonin-salmon
- Outcome
- IncreaseCortical vertebral bone mineral content
- Study
n = 9
- Comparator
- 1 alpha-hydroxyvitamin D3 alone
- Outcome group
- Bone and joint · Musculoskeletal
- Studied dose
- 100 U on alternate days · intranasal · 16 monthsAs given in this study (human).
Source sentences
The bone mineral content was preserved in both cortical and spongeous areas of the vertebrae during the 16-month period in the calcitonin-treated group but was decreased significantly in the control group.
2 context sentences(design, population, supporting numbers)
To determine the effect of intranasal administration of salmon calcitonin on glucocorticoid-induced osteoporosis in children with nephrosis, we gave 100 U of calcitonin intranasally on alternate days with 1 alpha-hydroxyvitamin D3 to five children, 8 to 12 years of age, with frequently relapsing nephrosis.
Four patients with osteoporosis, 10 to 14 years of age, were treated only with 1 alpha-hydroxyvitamin D3 and served as control subjects.