Vasoactive intestinal peptide and secretin: effects of combined and separate intravenous infusions on bile secretion in man.

Nyberg B, Sonnenfeld T, Einarsson K

Scandinavian journal of gastroenterology1 Jan 1991Cited by 12 (Europe PMC)

PMID2006391DOI10.3109/00365529108996491PepBankPUB-02006391

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

6 results from studies that gave the peptide. 6 results from people.

01HumanNon-randomized trialEfficacy outcome
In patients with biliary fistulas, VIP infusion increased bile volume by 60%.
In plain wordsIn patients with biliary fistulas, VIP infusion increased bile volume.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreaseBile volume during VIP infusion
Study
n = 12
Outcome group
Gastrointestinal function · Liver
Studied dose
Dose not stated · intravenousAs given in this study (human).
Measurements
bile volume increase
60%
VIP infusion
Source sentences
Summary
During VIP infusion bile volume increased by 60%
2 context sentences(design, population, supporting numbers)
Summary · context
The effects of intravenously administered vasoactive intestinal peptide (VIP) and secretin on bile secretion were studied in 12 patients with complete biliary fistulas.
Summary · context
The two peptides were administered both simultaneously and separately.
Report a problemFND-0200639101
02HumanNon-randomized trialEfficacy outcome
In patients with biliary fistulas, VIP increased bile bicarbonate concentration by about 30%.
In plain wordsIn patients with biliary fistulas, VIP increased the bicarbonate concentration in bile.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreaseBile bicarbonate concentration
Study
n = 12
Outcome group
Gastrointestinal function · Liver
Studied dose
Dose not stated · intravenousAs given in this study (human).
Measurements
bile bicarbonate concentration increase
30%
VIP infusion
Source sentences
Summary
VIP increased bile bicarbonate concentration by some 30%.
2 context sentences(design, population, supporting numbers)
Summary · context
The effects of intravenously administered vasoactive intestinal peptide (VIP) and secretin on bile secretion were studied in 12 patients with complete biliary fistulas.
Summary · context
The two peptides were administered both simultaneously and separately.
Report a problemFND-0200639103
03HumanNon-randomized trialEfficacy outcome
In patients with biliary fistulas, bicarbonate output in bile increased twofold during VIP infusion.
In plain wordsIn patients with biliary fistulas, VIP infusion increased the amount of bicarbonate in bile.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreaseBile bicarbonate output
Study
n = 12
Outcome group
Gastrointestinal function · Liver
Studied dose
Dose not stated · intravenousAs given in this study (human).
Source sentences
Summary
Although secretin did not increase the concentration, bicarbonate output increased threefold during secretin infusion but only twofold during VIP infusion.
2 context sentences(design, population, supporting numbers)
Summary · context
The effects of intravenously administered vasoactive intestinal peptide (VIP) and secretin on bile secretion were studied in 12 patients with complete biliary fistulas.
Summary · context
The two peptides were administered both simultaneously and separately.
Report a problemFND-0200639104
04HumanNon-randomized trialEfficacy outcome
In patients with biliary fistulas, VIP did not significantly change bile acid output.
In plain wordsIn patients with biliary fistulas, VIP did not clearly change the amount of bile acids released.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
No significant changeBile acid output
Study
n = 12
Outcome group
Gastrointestinal function · Liver
Studied dose
Dose not stated · intravenousAs given in this study (human).
Source sentences
Summary
The outputs of bile acids were not significantly affected by the two peptides
2 context sentences(design, population, supporting numbers)
Summary · context
The effects of intravenously administered vasoactive intestinal peptide (VIP) and secretin on bile secretion were studied in 12 patients with complete biliary fistulas.
Summary · context
The two peptides were administered both simultaneously and separately.
Report a problemFND-0200639105
05HumanNon-randomized trialEfficacy outcome
In patients with biliary fistulas, VIP decreased bile acid concentration by 40%.
In plain wordsIn patients with biliary fistulas, VIP lowered the bile acid concentration in bile.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
DecreaseBile acid concentration
Study
n = 12
Outcome group
Gastrointestinal function · Liver
Studied dose
Dose not stated · intravenousAs given in this study (human).
Measurements
bile acid concentration decrease
40%
VIP infusion
Source sentences
Summary
whereas the concentrations decreased by 40% and 70% after VIP and secretin, respectively.
2 context sentences(design, population, supporting numbers)
Summary · context
The effects of intravenously administered vasoactive intestinal peptide (VIP) and secretin on bile secretion were studied in 12 patients with complete biliary fistulas.
Summary · context
The two peptides were administered both simultaneously and separately.
Report a problemFND-0200639106
06HumanNon-randomized trialEfficacy outcome
In patients with biliary fistulas, canalicular bile flow measured by [14C]erythritol was unaffected by VIP infusion.
In plain wordsIn patients with biliary fistulas, VIP did not change canalicular bile flow.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
No significant changeCanalicular bile flow
Study
n = 12
Outcome group
Gastrointestinal function · Liver
Studied dose
Dose not stated · intravenousAs given in this study (human).
Source sentences
Summary
The canalicular bile flow, measured by [14C]erythritol, was unaffected by VIP infusion
2 context sentences(design, population, supporting numbers)
Summary · context
The effects of intravenously administered vasoactive intestinal peptide (VIP) and secretin on bile secretion were studied in 12 patients with complete biliary fistulas.
Summary · context
The two peptides were administered both simultaneously and separately.
Report a problemFND-0200639107

Studies that did not test the peptide alone2

In this study, Vasoactive intestinal peptide (VIP, aviptadil) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Vasoactive intestinal peptide (VIP, aviptadil).

07HumanNot a test of Vasoactive intestinal peptide (VIP, aviptadil) aloneNon-randomized trialEfficacy outcome
In patients with biliary fistulas, combined VIP and secretin infusion increased bile volume by another 70%.
In plain wordsIn patients with biliary fistulas, giving VIP and secretin together increased bile volume further.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreaseBile volume during combined VIP and secretin infusion
Study
n = 12
Comparator
VIP infusion alone
Outcome group
Gastrointestinal function · Liver
Measurements
additional bile volume increase
70%
VIP plus secretin infusion
Source sentences
Summary
and during the combined VIP and secretin infusion bile volume increased by another 70%.
2 context sentences(design, population, supporting numbers)
Summary · context
The effects of intravenously administered vasoactive intestinal peptide (VIP) and secretin on bile secretion were studied in 12 patients with complete biliary fistulas.
Summary · context
The two peptides were administered both simultaneously and separately.
In this study, Vasoactive intestinal peptide (VIP, aviptadil) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Vasoactive intestinal peptide (VIP, aviptadil).
Report a problemFND-0200639102
08HumanNot a test of Vasoactive intestinal peptide (VIP, aviptadil) aloneNon-randomized trialEfficacy outcome
In patients with biliary fistulas, combined VIP and secretin infusion increased canalicular clearance by 80%, as secretin alone did.
In plain wordsIn patients with biliary fistulas, giving VIP and secretin together increased canalicular clearance, as secretin alone did.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreaseCanalicular clearance during combined VIP and secretin infusion
Study
n = 12
Outcome group
Gastrointestinal function · Liver
Measurements
canalicular clearance increase
80%
VIP plus secretin infusion
Source sentences
Summary
whereas secretin alone and the combination of the two peptides increased the canalicular clearance by 80%.
2 context sentences(design, population, supporting numbers)
Summary · context
The effects of intravenously administered vasoactive intestinal peptide (VIP) and secretin on bile secretion were studied in 12 patients with complete biliary fistulas.
Summary · context
The two peptides were administered both simultaneously and separately.
In this study, Vasoactive intestinal peptide (VIP, aviptadil) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Vasoactive intestinal peptide (VIP, aviptadil).
Report a problemFND-0200639108

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
12 Oct 2026, 12:58 UTC
Study results updated
Version 1
9 Oct 2026, 12:41 UTC
First added · source update from Europe PMC

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