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Study · Animal study (in vivo) · rat · 1991

11 results

Effects of full-length and truncated insulin-like growth factor-I on nitrogen balance and muscle protein metabolism in nitrogen-restricted rats.

Tomas FM, Knowles SE, Owens PC, Read LC, Chandler CS, Gargosky SE, Ballard FJ

The Journal of endocrinology1 Jan 1991Cited by 47 (Europe PMC)

PMID1999680 (opens in a new tab)DOI10.1677/joe.0.1280097 (opens in a new tab)PepBankPUB-01999680
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study11

10 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In nitrogen-restricted rats, des(1‑3)IGF-I did not measurably prevent the reduction in plasma IGF-I levels.

    In plain wordsIn rats with restricted dietary nitrogen, des(1‑3)IGF-I did not measurably prevent lower blood IGF-I levels.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    No significant changePlasma IGF-I levels
    Study

    ratn: not reported in source

    Dietary nitrogen restriction
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    1.2 mg/kg per day · 7 daysAs given in this study (rat).

    Source sentences

    Summary
    Plasma IGF-I levels were reduced by 60% following nitrogen restriction, a reduction that was partly prevented by IGF-I administration, especially at the higher dose, but not measurably by des(1-3)IGF-I.
    2 context sentences
    Summary · context
    The ability of insulin-like growth factor-I (IGF-I) to protect against losses of body protein during periods of dietary nitrogen restriction has been evaluated in young rats.
    Summary · context
    A fourth group received the potent truncated IGF-I analogue, des(1-3)IGF-I, at a dose of 1.2 mg/kg per day over a comparable 7-day period.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In nitrogen-restricted rats, circulating IGFBP-3 followed the IGF-I pattern, without measurable prevention by des(1‑3)IGF-I.

    In plain wordsIn rats with restricted dietary nitrogen, des(1‑3)IGF-I did not measurably prevent the fall in circulating IGFBP-3.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    No significant changeCirculating IGFBP-3
    Study

    ratn: not reported in source

    Dietary nitrogen restriction
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    1.2 mg/kg per day · 7 daysAs given in this study (rat).

    Source sentences

    Summary
    The major IGF-binding protein circulating in blood, IGFBP-3, demonstrated a similar pattern of change.
    3 context sentences
    Summary · context
    Plasma IGF-I levels were reduced by 60% following nitrogen restriction, a reduction that was partly prevented by IGF-I administration, especially at the higher dose, but not measurably by des(1-3)IGF-I.
    Summary · context
    The ability of insulin-like growth factor-I (IGF-I) to protect against losses of body protein during periods of dietary nitrogen restriction has been evaluated in young rats.
    Summary · context
    A fourth group received the potent truncated IGF-I analogue, des(1-3)IGF-I, at a dose of 1.2 mg/kg per day over a comparable 7-day period.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In nitrogen-restricted rats, des(1‑3)IGF-I protected body weight significantly only after covariance adjustment for food intake.

    In plain wordsIn rats with restricted dietary nitrogen, des(1‑3)IGF-I protected weight only after adjustment for food intake differences.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    IncreaseBody weight adjusted for food intake
    Study

    ratn: not reported in source

    Dietary nitrogen restriction
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    1.2 mg/kg per day · 7 daysAs given in this study (rat).

    Source sentences

    Summary
    A significant (P less than 0.05) protection of body weight was achieved in the low dose IGF-I and des(1-3)IGF-I groups, but only after differences in food intake had been eliminated by analysis of covariance.
    2 context sentences
    Summary · context
    The ability of insulin-like growth factor-I (IGF-I) to protect against losses of body protein during periods of dietary nitrogen restriction has been evaluated in young rats.
    Summary · context
    A fourth group received the potent truncated IGF-I analogue, des(1-3)IGF-I, at a dose of 1.2 mg/kg per day over a comparable 7-day period.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In nitrogen-restricted rats, nitrogen balances did not differ significantly without covariance adjustment.

    In plain wordsIn rats with restricted dietary nitrogen, des(1‑3)IGF-I did not significantly change unadjusted nitrogen balance.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    No significant changeUnadjusted nitrogen balance
    Study

    ratn: not reported in source

    Dietary nitrogen restriction
    Outcome group
    Muscle injury and repair · Musculoskeletal
    Studied dose
    1.2 mg/kg per day · 7 daysAs given in this study (rat).

    Source sentences

    Summary
    Nitrogen balances were not significantly different unless analysis of covariance was used to adjust for the nitrogen intakes, whereupon all treatment groups showed improved balance, especially the animals treated with the low IGF-I dose and des(1-3)IGF-I (both P less than 0.01).
    2 context sentences
    Summary · context
    The ability of insulin-like growth factor-I (IGF-I) to protect against losses of body protein during periods of dietary nitrogen restriction has been evaluated in young rats.
    Summary · context
    A fourth group received the potent truncated IGF-I analogue, des(1-3)IGF-I, at a dose of 1.2 mg/kg per day over a comparable 7-day period.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In nitrogen-restricted rats, des(1‑3)IGF-I improved nitrogen balance after adjustment for nitrogen intake.

    In plain wordsIn rats with restricted dietary nitrogen, des(1‑3)IGF-I improved nitrogen balance after adjustment for nitrogen intake.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    IncreaseNitrogen balance adjusted for intake
    Study

    ratn: not reported in source

    Dietary nitrogen restriction
    Outcome group
    Muscle injury and repair · Musculoskeletal
    Studied dose
    1.2 mg/kg per day · 7 daysAs given in this study (rat).

    Source sentences

    Summary
    Nitrogen balances were not significantly different unless analysis of covariance was used to adjust for the nitrogen intakes, whereupon all treatment groups showed improved balance, especially the animals treated with the low IGF-I dose and des(1-3)IGF-I (both P less than 0.01).
    2 context sentences
    Summary · context
    The ability of insulin-like growth factor-I (IGF-I) to protect against losses of body protein during periods of dietary nitrogen restriction has been evaluated in young rats.
    Summary · context
    A fourth group received the potent truncated IGF-I analogue, des(1-3)IGF-I, at a dose of 1.2 mg/kg per day over a comparable 7-day period.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In nitrogen-restricted rats, treatments including des(1‑3)IGF-I did not significantly alter muscle protein breakdown despite a decline over time.

    In plain wordsIn rats with restricted dietary nitrogen, des(1‑3)IGF-I did not significantly change muscle protein breakdown.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    No significant changeMuscle protein breakdown
    Study

    ratn: not reported in source

    Dietary nitrogen restriction
    Outcome group
    Muscle injury and repair · Musculoskeletal
    Studied dose
    1.2 mg/kg per day · 7 daysAs given in this study (rat).

    Source sentences

    Summary
    The rate of muscle protein breakdown calculated from the urinary excretion of 3-methyl-histidine was not significantly altered by the treatments, but fell progressively throughout the 7 days.
    2 context sentences
    Summary · context
    The ability of insulin-like growth factor-I (IGF-I) to protect against losses of body protein during periods of dietary nitrogen restriction has been evaluated in young rats.
    Summary · context
    A fourth group received the potent truncated IGF-I analogue, des(1-3)IGF-I, at a dose of 1.2 mg/kg per day over a comparable 7-day period.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In nitrogen-restricted rats, des(1‑3)IGF-I increased final-day fractional muscle protein synthesis by 21%.

    In plain wordsIn rats with restricted dietary nitrogen, des(1‑3)IGF-I increased muscle protein production by 21%.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    IncreaseMuscle protein synthesis
    Study

    ratn: not reported in source

    Dietary nitrogen restriction
    Outcome group
    Muscle injury and repair · Musculoskeletal
    Studied dose
    1.2 mg/kg per day · 7 daysAs given in this study (rat).

    Measurements

    Muscle protein synthesis increase
    21%
    des(1-3)IGF-I, final day

    Source sentences

    Summary
    The fractional rate of muscle protein synthesis measured on the final day was increased by 31,26 and 21% respectively by the low and high doses of IGF-I and by des(1-3)IGF-I.
    2 context sentences
    Summary · context
    The ability of insulin-like growth factor-I (IGF-I) to protect against losses of body protein during periods of dietary nitrogen restriction has been evaluated in young rats.
    Summary · context
    A fourth group received the potent truncated IGF-I analogue, des(1-3)IGF-I, at a dose of 1.2 mg/kg per day over a comparable 7-day period.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In nitrogen-restricted rats, des(1‑3)IGF-I increased relative kidney weight by 16%.

    In plain wordsIn rats with restricted dietary nitrogen, des(1‑3)IGF-I increased kidney weight relative to body weight by 16%.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    IncreaseRelative kidney weight
    Study

    ratn: not reported in source

    Dietary nitrogen restriction
    Outcome group
    Body composition · Kidney and urinary
    Studied dose
    1.2 mg/kg per day · 7 daysAs given in this study (rat).

    Measurements

    Relative kidney weight increase
    16%
    des(1-3)IGF-I

    Source sentences

    Summary
    Organ weights (g/kg body weight) showed no effects of IGF-I treatment except for 16% increases in the weight of kidneys in the high dose IGF-I and the des(1-3)IGF-I groups.
    2 context sentences
    Summary · context
    The ability of insulin-like growth factor-I (IGF-I) to protect against losses of body protein during periods of dietary nitrogen restriction has been evaluated in young rats.
    Summary · context
    A fourth group received the potent truncated IGF-I analogue, des(1-3)IGF-I, at a dose of 1.2 mg/kg per day over a comparable 7-day period.
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In nitrogen-restricted rats, des(1‑3)IGF-I increased carcass water content.

    In plain wordsIn rats with restricted dietary nitrogen, des(1‑3)IGF-I increased body water content.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    IncreaseCarcass water content
    Study

    ratn: not reported in source

    Dietary nitrogen restriction
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    1.2 mg/kg per day · 7 daysAs given in this study (rat).

    Source sentences

    Summary
    Carcass analyses demonstrated higher water and lower fat contents (all P less than 0.01) in the same groups.
    3 context sentences
    Summary · context
    Organ weights (g/kg body weight) showed no effects of IGF-I treatment except for 16% increases in the weight of kidneys in the high dose IGF-I and the des(1-3)IGF-I groups.
    Summary · context
    The ability of insulin-like growth factor-I (IGF-I) to protect against losses of body protein during periods of dietary nitrogen restriction has been evaluated in young rats.
    Summary · context
    A fourth group received the potent truncated IGF-I analogue, des(1-3)IGF-I, at a dose of 1.2 mg/kg per day over a comparable 7-day period.
  10. 10AnimalAnimal study (in vivo)Efficacy outcome

    In nitrogen-restricted rats, des(1‑3)IGF-I reduced carcass fat content.

    In plain wordsIn rats with restricted dietary nitrogen, des(1‑3)IGF-I reduced body fat content.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    DecreaseCarcass fat content
    Study

    ratn: not reported in source

    Dietary nitrogen restriction
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    1.2 mg/kg per day · 7 daysAs given in this study (rat).

    Source sentences

    Summary
    Carcass analyses demonstrated higher water and lower fat contents (all P less than 0.01) in the same groups.
    3 context sentences
    Summary · context
    Organ weights (g/kg body weight) showed no effects of IGF-I treatment except for 16% increases in the weight of kidneys in the high dose IGF-I and the des(1-3)IGF-I groups.
    Summary · context
    The ability of insulin-like growth factor-I (IGF-I) to protect against losses of body protein during periods of dietary nitrogen restriction has been evaluated in young rats.
    Summary · context
    A fourth group received the potent truncated IGF-I analogue, des(1-3)IGF-I, at a dose of 1.2 mg/kg per day over a comparable 7-day period.

Studies that did not test the peptide alone1

In this study, IGF-1 DES (des(1-3)IGF-I) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking IGF-1 DES (des(1-3)IGF-I).

  1. 11AnimalNot a test of IGF-1 DES (des(1-3)IGF-I) aloneAnimal study (in vivo)Efficacy outcome

    In nitrogen-restricted rats, IGF treatment did not affect relative organ weights except kidney weight, without a separate des(1‑3)IGF-I result.

    In plain wordsIn rats with restricted dietary nitrogen, IGF treatment did not change relative organ weights except kidney weight. No separate des(1‑3)IGF-I result appears.

    Peptide
    IGF-1 DES (des(1-3)IGF-I)
    Outcome
    No significant changeOther relative organ weights
    Study

    ratn: not reported in source

    Dietary nitrogen restriction
    Outcome group
    Body composition · Whole body

    Source sentences

    Summary
    Organ weights (g/kg body weight) showed no effects of IGF-I treatment except for 16% increases in the weight of kidneys in the high dose IGF-I and the des(1-3)IGF-I groups.
    2 context sentences
    Summary · context
    The ability of insulin-like growth factor-I (IGF-I) to protect against losses of body protein during periods of dietary nitrogen restriction has been evaluated in young rats.
    Summary · context
    A fourth group received the potent truncated IGF-I analogue, des(1-3)IGF-I, at a dose of 1.2 mg/kg per day over a comparable 7-day period.

    In this study, IGF-1 DES (des(1-3)IGF-I) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking IGF-1 DES (des(1-3)IGF-I).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 2

    21 Oct 2026, 13:52 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

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