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Study · Not a test of the peptide alone · 1991

2 results

Comparison of the estrogen responsiveness of the rat and bovine oxytocin gene promoters.

Adan RA, Walther N, Cox JJ, Ivell R, Burbach JP

Biochemical and biophysical research communications1 Feb 1991Cited by 36 (Europe PMC)

PMID1998497 (opens in a new tab)DOI10.1016/s0006-291x(05)81208-2 (opens in a new tab)PepBankPUB-01998497
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone2

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

  1. 01LabNot a test of Oxytocin aloneIn vitro (cells)Mechanism

    In estrogen receptor expressing MCF-7 cells, bovine oxytocin gene promoter sequences up to 3200 bp did not respond to estrogen, unlike the rat gene.

    In plain wordsIn cells, the switch of the cow gene for the body's own oxytocin did not respond to estrogen, but the rat switch did.

    Peptide
    Oxytocin
    Outcome
    No significant changeEstrogen responsiveness of the bovine oxytocin gene promoter
    Study

    n: not reported in source

    MCF-7 cells expressing estrogen receptor, CAT reporter
    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Source sentences

    Summary
    In contrast to the 5'-flanking region of the rat oxytocin gene, upstream promoter sequences up to 3200 bp of the bovine gene linked to the chloramphenicol acetyltransferase (CAT) reporter gene which were transfected in estrogen receptor expressing MCF-7 cells did not respond to estrogen.
    1 context sentence
    Summary · context
    DNA sequences in the 5'-flanking region of rat and bovine oxytocin genes were examined for their capacity to confer estrogen responsiveness to their homologous promoters.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

  2. 02LabNot a test of Oxytocin aloneIn vitro (cells)Mechanism

    In P19 cells with an estrogen receptor plasmid, two regions of the rat oxytocin gene upstream sequence each gave about 15-fold stimulation of promoter activity.

    In plain wordsIn cells, two parts of the rat gene for the body's own oxytocin each raised gene activity about 15-fold with estrogen receptor present.

    Peptide
    Oxytocin
    Outcome
    IncreaseEstrogen-stimulated activity of the rat oxytocin gene promoter regions
    Study

    n: not reported in source

    P19 embryocarcinoma cells with estrogen receptor plasmid, luciferase reporter
    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Measurements

    Promoter activity stimulation
    15 fold
    rat upstream regions

    Source sentences

    Summary
    Testing 5'-deletion mutants of the rat upstream region linked to the luciferase gene in P19 embryocarcinoma cells co-transfected with an estrogen receptor expression plasmid showed that two regions each associated with approximately 15-fold stimulation of promoter activity were located between nucle…
    1 context sentence
    Summary · context
    DNA sequences in the 5'-flanking region of rat and bovine oxytocin genes were examined for their capacity to confer estrogen responsiveness to their homologous promoters.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:52 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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