IGF-I and the truncated analogue des-(1-3)IGF-I enhance growth in rats after gut resection.

Lemmey AB, Martin AA, Read LC, Tomas FM, Owens PC, Ballard FJ

The American journal of physiology1 Feb 1991Cited by 60 (Europe PMC)

PMID1996625DOI10.1152/ajpendo.1991.260.2.e213PepBankPUB-01996625

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats after gut resection, des-(1-3)IGF-I improved weight stabilization over the next 3 days after postoperative weight loss.
In plain wordsIn rats after gut surgery, des-(1-3)IGF-I stabilized weight better than vehicle or low-dose IGF-I.
Peptide
IGF-1 DES (des(1-3)IGF-I)
Outcome
IncreaseBody weight stabilization
Study
ratn: not reported in source
80% jejunum and ileum resection
Comparator
Vehicle or low-dose IGF-I
Outcome group
Body weight · Metabolic and weight
Studied dose
0.96 mg/kg per day · 7 daysAs given in this study (rat).
Source sentences
Summary
All groups lost weight on the day after surgery, but over the next 3 days the des-(1-3)IGF-I and high-dose IGF-I groups stabilized better and subsequently gained significantly (P less than 0.05) more weight than the vehicle or low-dose IGF-I groups over the last 3 days.
2 context sentences(design, population, supporting numbers)
Summary · context
Effects of insulin-like growth factor I (IGF-I) administration and that of the truncated analogue des-(1-3)IGF-I have been examined in 170-g rats over a 7-day period after surgery to remove 80% of the jejunum plus ileum.
Summary · context
The doses administered via osmotic infusion pumps were 0.96 and 2.4 mg.kg-1.day-1 IGF-I and 0.96 mg.kg-1.day-1 des-(1-3)IGF-I.
Report a problemFND-0199662501
02AnimalAnimal study (in vivo)Efficacy outcome
In rats after gut resection, des-(1-3)IGF-I increased final-period weight gain to 20.8 g versus 14.0 g with vehicle.
In plain wordsIn rats after gut surgery, des-(1-3)IGF-I increased weight gain more than vehicle.
Peptide
IGF-1 DES (des(1-3)IGF-I)
Outcome
IncreaseBody weight gain versus vehicle
Study
ratn: not reported in source
80% jejunum and ileum resection
Comparator
Vehicle
Outcome group
Body weight · Metabolic and weight
Studied dose
0.96 mg/kg per day · 7 daysAs given in this study (rat).
Measurements
Weight gain
20.8 g
des-(1-3)IGF-I, last 3 days
Weight gain
14 g
vehicle, last 3 days
Source sentences
Summary
The weight gains (mean +/- SE) for the groups over this last 3-day period were 14.0 +/- 1.7, 14.4 +/- 2.9, 21.9 +/- 1.7, and 20.8 +/- 1.0 g for the vehicle, low-dose IGF-I, high-dose IGF-I, and des-(1-3)IGF-I groups, respectively.
3 context sentences(design, population, supporting numbers)
Summary · context
All groups lost weight on the day after surgery, but over the next 3 days the des-(1-3)IGF-I and high-dose IGF-I groups stabilized better and subsequently gained significantly (P less than 0.05) more weight than the vehicle or low-dose IGF-I groups over the last 3 days.
Summary · context
Effects of insulin-like growth factor I (IGF-I) administration and that of the truncated analogue des-(1-3)IGF-I have been examined in 170-g rats over a 7-day period after surgery to remove 80% of the jejunum plus ileum.
Summary · context
The doses administered via osmotic infusion pumps were 0.96 and 2.4 mg.kg-1.day-1 IGF-I and 0.96 mg.kg-1.day-1 des-(1-3)IGF-I.
Report a problemFND-0199662502
03AnimalAnimal study (in vivo)Efficacy outcome
In rats after gut resection, des-(1-3)IGF-I increased final-period weight gain to 20.8 g versus 14.4 g with low-dose IGF-I.
In plain wordsIn rats after gut surgery, des-(1-3)IGF-I increased weight gain more than low-dose IGF-I.
Peptide
IGF-1 DES (des(1-3)IGF-I)
Outcome
IncreaseBody weight gain versus low-dose IGF-I
Study
ratn: not reported in source
80% jejunum and ileum resection
Comparator
Low-dose IGF-I
Outcome group
Body weight · Metabolic and weight
Studied dose
0.96 mg/kg per day · 7 daysAs given in this study (rat).
Measurements
Weight gain
20.8 g
des-(1-3)IGF-I, last 3 days
Weight gain
14.4 g
low-dose IGF-I, last 3 days
Source sentences
Summary
The weight gains (mean +/- SE) for the groups over this last 3-day period were 14.0 +/- 1.7, 14.4 +/- 2.9, 21.9 +/- 1.7, and 20.8 +/- 1.0 g for the vehicle, low-dose IGF-I, high-dose IGF-I, and des-(1-3)IGF-I groups, respectively.
3 context sentences(design, population, supporting numbers)
Summary · context
All groups lost weight on the day after surgery, but over the next 3 days the des-(1-3)IGF-I and high-dose IGF-I groups stabilized better and subsequently gained significantly (P less than 0.05) more weight than the vehicle or low-dose IGF-I groups over the last 3 days.
Summary · context
Effects of insulin-like growth factor I (IGF-I) administration and that of the truncated analogue des-(1-3)IGF-I have been examined in 170-g rats over a 7-day period after surgery to remove 80% of the jejunum plus ileum.
Summary · context
The doses administered via osmotic infusion pumps were 0.96 and 2.4 mg.kg-1.day-1 IGF-I and 0.96 mg.kg-1.day-1 des-(1-3)IGF-I.
Report a problemFND-0199662503
04AnimalAnimal study (in vivo)Efficacy outcome
In rats after gut resection, des-(1-3)IGF-I increased final-period nitrogen balance to 217 mg/d versus 153 mg/d in controls.
In plain wordsIn rats after gut surgery, des-(1-3)IGF-I improved nitrogen balance compared with controls.
Peptide
IGF-1 DES (des(1-3)IGF-I)
Outcome
IncreaseNitrogen balance
Study
ratn: not reported in source
80% jejunum and ileum resection
Comparator
Control
Outcome group
Muscle injury and repair · Musculoskeletal
Studied dose
0.96 mg/kg per day · 7 daysAs given in this study (rat).
Measurements
Nitrogen balance
217 mg/d
des-(1-3)IGF-I, last 3 days
Nitrogen balance
153 mg/d
control, last 3 days
Source sentences
Summary
The nitrogen balances over the last 3 days for the high-dose IGF-I and des-(1-3)IGF-I groups, at 242 +/- 14 and 217 +/- 13 mg/d, respectively, were significantly (P less than 0.05) more positive than the control group at 153 +/- 21 mg/d.
2 context sentences(design, population, supporting numbers)
Summary · context
Effects of insulin-like growth factor I (IGF-I) administration and that of the truncated analogue des-(1-3)IGF-I have been examined in 170-g rats over a 7-day period after surgery to remove 80% of the jejunum plus ileum.
Summary · context
The doses administered via osmotic infusion pumps were 0.96 and 2.4 mg.kg-1.day-1 IGF-I and 0.96 mg.kg-1.day-1 des-(1-3)IGF-I.
Report a problemFND-0199662504
05AnimalAnimal study (in vivo)Mechanism
In rats after gut resection, changes in muscle protein breakdown could partly explain nitrogen balance differences with des-(1-3)IGF-I.
In plain wordsIn rats after gut surgery, muscle protein breakdown changes could partly explain nitrogen balance differences with des-(1-3)IGF-I.
Peptide
IGF-1 DES (des(1-3)IGF-I)
Outcome
Direction not reportedMuscle protein breakdown
Study
ratn: not reported in source
80% jejunum and ileum resection
Outcome group
Muscle injury and repair · Musculoskeletal
Studied dose
0.96 mg/kg per day · 7 daysAs given in this study (rat).
Source sentences
Summary
These differences could at least partially be explained by changes in muscle protein breakdown, as assessed by 3-methyl-L-histidine excretion.
3 context sentences(design, population, supporting numbers)
Summary · context
The nitrogen balances over the last 3 days for the high-dose IGF-I and des-(1-3)IGF-I groups, at 242 +/- 14 and 217 +/- 13 mg/d, respectively, were significantly (P less than 0.05) more positive than the control group at 153 +/- 21 mg/d.
Summary · context
Effects of insulin-like growth factor I (IGF-I) administration and that of the truncated analogue des-(1-3)IGF-I have been examined in 170-g rats over a 7-day period after surgery to remove 80% of the jejunum plus ileum.
Summary · context
The doses administered via osmotic infusion pumps were 0.96 and 2.4 mg.kg-1.day-1 IGF-I and 0.96 mg.kg-1.day-1 des-(1-3)IGF-I.
Report a problemFND-0199662505
06AnimalAnimal study (in vivo)Efficacy outcome
In rats after gut resection, kidneys were heavier in all treatment groups, including des-(1-3)IGF-I.
In plain wordsIn rats after gut surgery, all treatment groups, including des-(1-3)IGF-I, had heavier kidneys.
Peptide
IGF-1 DES (des(1-3)IGF-I)
Outcome
IncreaseKidney weight
Study
ratn: not reported in source
80% jejunum and ileum resection
Outcome group
Body composition · Kidney and urinary
Studied dose
0.96 mg/kg per day · 7 daysAs given in this study (rat).
Source sentences
Summary
The kidneys were heavier in all treatment groups and the thymus after administration of des-(1-3)IGF-I.(ABSTRACT TRUNCATED AT 250 WORDS)
2 context sentences(design, population, supporting numbers)
Summary · context
Effects of insulin-like growth factor I (IGF-I) administration and that of the truncated analogue des-(1-3)IGF-I have been examined in 170-g rats over a 7-day period after surgery to remove 80% of the jejunum plus ileum.
Summary · context
The doses administered via osmotic infusion pumps were 0.96 and 2.4 mg.kg-1.day-1 IGF-I and 0.96 mg.kg-1.day-1 des-(1-3)IGF-I.
Report a problemFND-0199662506
07AnimalAnimal study (in vivo)Efficacy outcome
In rats after gut resection, des-(1-3)IGF-I increased thymus weight.
In plain wordsIn rats after gut surgery, des-(1-3)IGF-I increased thymus weight.
Peptide
IGF-1 DES (des(1-3)IGF-I)
Outcome
IncreaseThymus weight
Study
ratn: not reported in source
80% jejunum and ileum resection
Outcome group
Body composition · Immune and inflammation
Studied dose
0.96 mg/kg per day · 7 daysAs given in this study (rat).
Source sentences
Summary
The kidneys were heavier in all treatment groups and the thymus after administration of des-(1-3)IGF-I.(ABSTRACT TRUNCATED AT 250 WORDS)
2 context sentences(design, population, supporting numbers)
Summary · context
Effects of insulin-like growth factor I (IGF-I) administration and that of the truncated analogue des-(1-3)IGF-I have been examined in 170-g rats over a 7-day period after surgery to remove 80% of the jejunum plus ileum.
Summary · context
The doses administered via osmotic infusion pumps were 0.96 and 2.4 mg.kg-1.day-1 IGF-I and 0.96 mg.kg-1.day-1 des-(1-3)IGF-I.
Report a problemFND-0199662507

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 3Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 2
21 Oct 2026, 13:52 UTC
Study data updated · source update from Europe PMC
Version 1
21 Oct 2026, 12:50 UTC
First added · source update from Europe PMC

Subjects

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MeSH terms

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