Electrophysiological effects of dermorphin on locus coeruleus neurons of rat.

Chiu TH, Chen TY, Ho CL, Chiang ST

Neuropharmacology1 Aug 1990Cited by 9 (Europe PMC)

PMID1980348DOI10.1016/0028-3908(90)90128-ePepBankPUB-01980348

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

5 results from studies that gave the peptide. No result from this study comes from people.

01LabEx vivo tissueMechanism
In rat brain slices, dermorphin inhibited spontaneous firing in all tested locus coeruleus neurons, with an IC50 of 7 nM.
In plain wordsIn lab tests, dermorphin inhibited spontaneous firing in rat locus coeruleus neurons.
Peptide
Dermorphin
Outcome
DecreaseSpontaneous neuronal firing
Study
ratn: not reported in source
Locus coeruleus neurons in brain slices
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated
Measurements
IC50
7 nM
Spontaneous firing inhibition
Source sentences
Summary
Dermorphin caused the inhibition of spontaneous firing of all neurons of the locus coeruleus tested, with an IC50 of 7 nM.
1 context sentence(design, population, supporting numbers)
Summary · context
Intracellular recording was used to study the effects of dermorphin on neurons of the locus coeruleus in the rat, in a totally submerged brain slice preparation.
Report a problemFND-0198034801
02LabEx vivo tissueMechanism
In rat brain slices, dermorphin was 16.5 times more potent than morphine at inhibiting spontaneous neuronal firing.
In plain wordsIn lab tests, dermorphin inhibited rat neuronal firing more potently than morphine.
Peptide
Dermorphin
Outcome
IncreasePotency for spontaneous firing inhibition
Study
ratn: not reported in source
Locus coeruleus neurons in brain slices
Comparator
Morphine
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated
Measurements
Relative potency
16.5 times
Versus morphine
Source sentences
Summary
Based on the inhibition of spontaneous firing rate, dermorphin was 16.5 times more potent than morphine.
1 context sentence(design, population, supporting numbers)
Summary · context
Intracellular recording was used to study the effects of dermorphin on neurons of the locus coeruleus in the rat, in a totally submerged brain slice preparation.
Report a problemFND-0198034802
03LabEx vivo tissueMechanism
In rat brain slices, dermorphin at 30-100 nM further hyperpolarized locus coeruleus neurons.
In plain wordsIn lab tests, higher dermorphin concentrations further hyperpolarized rat locus coeruleus neurons.
Peptide
Dermorphin
Outcome
IncreaseNeuronal hyperpolarization
Study
ratn: not reported in source
Locus coeruleus neurons in brain slices
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
30-100 nMAs given in this study (rat).
Source sentences
Summary
Larger concentrations of dermorphin (30-100 nM) further hyperpolarized the neurons of the locus coeruleus and simultaneously caused a reduction in input resistance.
1 context sentence(design, population, supporting numbers)
Summary · context
Intracellular recording was used to study the effects of dermorphin on neurons of the locus coeruleus in the rat, in a totally submerged brain slice preparation.
Report a problemFND-0198034803
04LabEx vivo tissueMechanism
In rat brain slices, dermorphin at 30-100 nM reduced neuronal input resistance.
In plain wordsIn lab tests, dermorphin reduced input resistance in rat locus coeruleus neurons.
Peptide
Dermorphin
Outcome
DecreaseInput resistance
Study
ratn: not reported in source
Locus coeruleus neurons in brain slices
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
30-100 nMAs given in this study (rat).
Source sentences
Summary
Larger concentrations of dermorphin (30-100 nM) further hyperpolarized the neurons of the locus coeruleus and simultaneously caused a reduction in input resistance.
1 context sentence(design, population, supporting numbers)
Summary · context
Intracellular recording was used to study the effects of dermorphin on neurons of the locus coeruleus in the rat, in a totally submerged brain slice preparation.
Report a problemFND-0198034804
05LabEx vivo tissueMechanism
In rat brain slices, dermorphin-induced hyperpolarization reversed at a membrane potential of -112 mV.
In plain wordsIn lab tests, dermorphin-induced hyperpolarization reversed at a specified membrane potential in rat neurons.
Peptide
Dermorphin
Outcome
Not applicableHyperpolarization reversal potential
Study
ratn: not reported in source
Locus coeruleus neurons in brain slices
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated
Measurements
Reversal potential
−112 mV
Dermorphin-induced hyperpolarization
Source sentences
Summary
The hyperpolarization of neurons of the locus coeruleus, caused by dermorphin, was reversed at a membrane potential of -112 mV in this preparation.
1 context sentence(design, population, supporting numbers)
Summary · context
Intracellular recording was used to study the effects of dermorphin on neurons of the locus coeruleus in the rat, in a totally submerged brain slice preparation.
Report a problemFND-0198034806

Studies that did not test the peptide alone2

In this study, Dermorphin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Dermorphin.

06LabNot a test of Dermorphin aloneEx vivo tissueMechanism
In rat brain slices, naloxone antagonized dermorphin effects with a dissociation equilibrium constant of 0.8 nM.
In plain wordsIn lab tests, naloxone antagonized dermorphin effects in rat neurons.
Peptide
Dermorphin
Outcome
Not applicableNaloxone antagonism
Study
ratn: not reported in source
Locus coeruleus neurons in brain slices
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Measurements
Dissociation equilibrium constant
0.8 nM
Naloxone antagonism
Source sentences
Summary
These effects were antagonized by naloxone, with a dissociation equilibrium constant of 0.8 nM.
1 context sentence(design, population, supporting numbers)
Summary · context
Intracellular recording was used to study the effects of dermorphin on neurons of the locus coeruleus in the rat, in a totally submerged brain slice preparation.
In this study, Dermorphin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Dermorphin.
Report a problemFND-0198034805
07LabNot a test of Dermorphin aloneEx vivo tissueMechanism
In rat brain slices, cesium chloride and barium chloride blocked dermorphin-induced hyperpolarization.
In plain wordsIn lab tests, cesium chloride and barium chloride blocked dermorphin-induced hyperpolarization in rat neurons.
Peptide
Dermorphin
Outcome
Not applicableIon channel blocker sensitivity
Study
ratn: not reported in source
Locus coeruleus neurons in brain slices
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Source sentences
Summary
Furthermore, this hyperpolarization was blocked by cesium chloride and barium chloride.
1 context sentence(design, population, supporting numbers)
Summary · context
Intracellular recording was used to study the effects of dermorphin on neurons of the locus coeruleus in the rat, in a totally submerged brain slice preparation.
In this study, Dermorphin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Dermorphin.
Report a problemFND-0198034807

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
27 Oct 2026, 18:20 UTC
Study results updated
Version 1
27 Oct 2026, 16:32 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.