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Study · Animal study (in vivo) · rat · 1990

3 results

The action of prolyl-leucyl-glycinamide (PLG) on the nigrostriatal pathway of the rat.

Pereira JS, Andrade LA, Bertolucci PH, Lima JG, Ferraz HB

Arquivos de neuro-psiquiatria1 Jun 1990

PMID1979732 (opens in a new tab)DOI10.1590/s0004-282x1990000200002 (opens in a new tab)PepBankPUB-01979732
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Activity measurement

    In lesioned male Wistar rats, PLG alone did not produce rotatory behavior.

    In plain wordsIn rats with brain lesions, PLG alone did not cause rotations.

    Peptide
    MIF-1 (Pro-Leu-Gly-NH2)
    Outcome
    No significant changeRotatory behavior with PLG alone
    Study

    ratn: not reported in source

    Male Wistar rats with electrolytic left lateral hypothalamic lesions
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The administration of PLG alone was not followed by rotatory behavior
    1 context sentence
    Summary · context
    In order to study the nigrostriatal pathway, we obtained the rotatory behavior model in male Wistar rats by electrolytic lesion of the left lateral hypothalamic region.
  2. 02AnimalAnimal study (in vivo)Activity measurement

    In lesioned REM-sleep-deprived rats, low-dose PLG with apomorphine increased rotations compared with controls.

    In plain wordsIn rats with lesions and REM sleep deprivation, low-dose PLG with apomorphine increased rotations compared with controls.

    Peptide
    MIF-1 (Pro-Leu-Gly-NH2)
    Outcome
    IncreaseRotations versus controls after REM sleep deprivation
    Study

    ratn: not reported in source

    Male Wistar rats with electrolytic left lateral hypothalamic lesions
    Comparator
    Controls
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    0.25 to 1mg/kgAs given in this study (rat).

    Source sentences

    Summary
    but when the compound was administered in low doses (0.25 to 1mg/kg) simultaneously with apomorphine to animals previously submitted to REM sleep deprivation, a significant increase in the number of rotations was observed in comparison with controls and groups receiving higher doses of PLG.
    1 context sentence
    Summary · context
    In order to study the nigrostriatal pathway, we obtained the rotatory behavior model in male Wistar rats by electrolytic lesion of the left lateral hypothalamic region.
  3. 03AnimalAnimal study (in vivo)Activity measurement

    In lesioned REM-sleep-deprived rats, low-dose PLG with apomorphine increased rotations compared with higher PLG doses.

    In plain wordsIn rats with lesions and REM sleep deprivation, low-dose PLG with apomorphine increased rotations more than higher PLG doses.

    Peptide
    MIF-1 (Pro-Leu-Gly-NH2)
    Outcome
    IncreaseRotations versus higher PLG doses after REM sleep deprivation
    Study

    ratn: not reported in source

    Male Wistar rats with electrolytic left lateral hypothalamic lesions
    Comparator
    Higher doses of PLG
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    0.25 to 1mg/kgAs given in this study (rat).

    Source sentences

    Summary
    but when the compound was administered in low doses (0.25 to 1mg/kg) simultaneously with apomorphine to animals previously submitted to REM sleep deprivation, a significant increase in the number of rotations was observed in comparison with controls and groups receiving higher doses of PLG.
    1 context sentence
    Summary · context
    In order to study the nigrostriatal pathway, we obtained the rotatory behavior model in male Wistar rats by electrolytic lesion of the left lateral hypothalamic region.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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