A vasoactive intestinal peptide-like cotransmitter at cholinergic synapses between rat myenteric neurons in cell culture.

Willard AL

The Journal of neuroscience : the official journal of the Society for Neuroscience1 Mar 1990Cited by 19 (Europe PMC)

PMID1969464PMCIDPMC6570126DOI10.1523/jneurosci.10-03-01025.1990PepBankPUB-01969464

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study4

2 results from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Mechanism
In cultured rat myenteric neurons, responses to exogenously applied VIP mimicked the slow EPSPs.
In plain wordsIn cells, VIP applied from outside copied the slow nerve signals seen in rat gut neurons.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
Not applicableResponse to exogenous VIP compared with slow EPSPs
Study
ratn: not reported in source
myenteric plexus neuron culture
Outcome group
Receptor activity and mechanism · Gastrointestinal
Studied dose
Dose not stated
Source sentences
Summary
(2) Responses to exogenously applied VIP mimicked the slow EPSPs.
1 context sentence(design, population, supporting numbers)
Summary · context
Intracellular recording and immunochemical techniques were used to study synaptic transmission between individual pairs of rat myenteric plexus neurons in cell culture.
Report a problemFND-0196946401
02LabIn vitro (cells)Mechanism
In cultured rat myenteric neurons, desensitizing doses of VIP blocked the slow EPSPs.
In plain wordsIn cells, large doses of VIP that make receptors less responsive blocked the slow nerve signals in rat gut neurons.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
DecreaseSlow EPSPs after desensitizing doses of VIP
Study
ratn: not reported in source
myenteric plexus neuron culture
Outcome group
Receptor activity and mechanism · Gastrointestinal
Studied dose
Dose not stated
Source sentences
Summary
as did application of desensitizing doses of VIP.
1 context sentence(design, population, supporting numbers)
Summary · context
Intracellular recording and immunochemical techniques were used to study synaptic transmission between individual pairs of rat myenteric plexus neurons in cell culture.
Report a problemFND-0196946402

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

03LabEndogenous levelIn vitro (cells)Other
In cultured rat myenteric neurons, VIP-like immunoreactivity was present in all physiologically identified dual-function neurons.
In plain wordsIn cells, the body's own VIP-like substance was found in all the rat gut neurons that gave slow signals.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
Not applicableVIP-like immunoreactivity in dual-function neurons
Study
ratn: not reported in source
myenteric plexus neuron culture
Outcome group
Endogenous peptide levels · Gastrointestinal
Source sentences
Summary
(1) Immunocytochemical staining revealed VIP-like immunoreactivity in all physiologically identified dual-function neurons.
1 context sentence(design, population, supporting numbers)
Summary · context
Intracellular recording and immunochemical techniques were used to study synaptic transmission between individual pairs of rat myenteric plexus neurons in cell culture.
This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0196946404

Studies that did not test the peptide alone1

In this study, Vasoactive intestinal peptide (VIP, aviptadil) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Vasoactive intestinal peptide (VIP, aviptadil).

04LabNot a test of Vasoactive intestinal peptide (VIP, aviptadil) aloneIn vitro (cells)Mechanism
In cultured rat myenteric neurons, superfusion with anti-VIP antisera reversibly blocked the slow EPSPs.
In plain wordsIn cells, antibodies against VIP reversibly blocked the slow nerve signals in rat gut neurons.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
DecreaseSlow EPSPs with anti-VIP antisera
Study
ratn: not reported in source
myenteric plexus neuron culture
Outcome group
Receptor activity and mechanism · Gastrointestinal
Source sentences
Summary
Superfusion of cultures with anti-VIP antisera blocked the slow EPSPs reversibly
1 context sentence(design, population, supporting numbers)
Summary · context
Intracellular recording and immunochemical techniques were used to study synaptic transmission between individual pairs of rat myenteric plexus neurons in cell culture.
In this study, Vasoactive intestinal peptide (VIP, aviptadil) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Vasoactive intestinal peptide (VIP, aviptadil).
Report a problemFND-0196946403

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
12 Oct 2026, 12:58 UTC
Study results updated
Version 1
9 Oct 2026, 12:41 UTC
First added · source update from Europe PMC

Subjects

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