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Study · Animal study (in vivo) · mouse and rat · 1990

3 results

Intensification and attenuation of morphine dependence by D-aspartic acid and PLG.

Koyuncuoğlu H, Güngör M, Sağduyu H, Aricioğlu F

Pharmacology, biochemistry, and behavior1 Jan 1990Cited by 4 (Europe PMC)

PMID1969165 (opens in a new tab)DOI10.1016/0091-3057(90)90202-s (opens in a new tab)PepBankPUB-01969165
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Activity measurement

    In mice and rats, PLG after morphine pellet implantation increased observed abstinence signs, including flying, jumping, wet dog shake and writhing.

    In plain wordsIn mice and rats, PLG after morphine pellet implantation increased observed withdrawal signs.

    Peptide
    MIF-1 (Pro-Leu-Gly-NH2)
    Outcome
    IncreaseAbstinence signs after morphine pellet implantation
    Study

    mouse and ratn: not reported in source

    Morphine pellet dependence and naloxone-precipitated abstinence
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    D-ASP or PLG administration following pellet implantation significantly increased all of the observed signs such as flying, jumping, wet dog shake and writhing.
    2 context sentences
    Summary · context
    As a result, L-asparaginase inhibitors D-aspartic acid and prolyl-leucyl-glycinamide (PLG) were separately given to mice and rats either just after morphine (M)-containing pellet implantation or 15 min before naloxone (NL)-precipitated abstinence syndrome.
    Summary · context
    The animals treated in this manner were used to assess the intensity of the physical dependence and to determine the BAA.
  2. 02AnimalAnimal study (in vivo)Activity measurement

    In mice and rats, PLG given before precipitated abstinence significantly decreased the number of abstinence signs.

    In plain wordsIn mice and rats, PLG before induced withdrawal reduced the number of withdrawal signs.

    Peptide
    MIF-1 (Pro-Leu-Gly-NH2)
    Outcome
    DecreaseAbstinence signs after pretreatment
    Study

    mouse and ratn: not reported in source

    Morphine pellet dependence and naloxone-precipitated abstinence
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    When D-ASP or PLG were given 15 min before precipitated abstinence they significantly decreased the number of the signs.
    2 context sentences
    Summary · context
    As a result, L-asparaginase inhibitors D-aspartic acid and prolyl-leucyl-glycinamide (PLG) were separately given to mice and rats either just after morphine (M)-containing pellet implantation or 15 min before naloxone (NL)-precipitated abstinence syndrome.
    Summary · context
    The animals treated in this manner were used to assess the intensity of the physical dependence and to determine the BAA.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In morphine-dependent mice and rats treated with PLG, brain L-asparaginase activity changed approximately in parallel with dependence severity.

    In plain wordsIn mice and rats treated with PLG, brain enzyme activity changed approximately with the severity of morphine dependence.

    Peptide
    MIF-1 (Pro-Leu-Gly-NH2)
    Outcome
    MixedBrain L-asparaginase activity
    Study

    mouse and ratn: not reported in source

    Morphine pellet dependence and naloxone-precipitated abstinence
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The determination of the BAA showed significant decreases or increases more or less parallel to the severity of the physical dependence on M.
    2 context sentences
    Summary · context
    As a result, L-asparaginase inhibitors D-aspartic acid and prolyl-leucyl-glycinamide (PLG) were separately given to mice and rats either just after morphine (M)-containing pellet implantation or 15 min before naloxone (NL)-precipitated abstinence syndrome.
    Summary · context
    The animals treated in this manner were used to assess the intensity of the physical dependence and to determine the BAA.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

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