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Study · Ex vivo tissue · brushtail possum · 1990

3 results

Uterine oxytocin receptors in an Australian marsupial, the brushtail possum, Trichosurus vulpecula.

Sernia C, Garcia-Aragon J, Thomas WG, Gemmell RT

Comparative biochemistry and physiology. A, Comparative physiology1 Jan 1990Cited by 5 (Europe PMC)

PMID1968806 (opens in a new tab)DOI10.1016/0300-9629(90)90021-j (opens in a new tab)PepBankPUB-01968806
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueActivity measurement

    In brushtail possum uterus, a single oxytocin binding site had an affinity (Kd) of 3.0 nmol/l and a receptor concentration of 200 fmol/mg protein.

    In plain wordsIn possum uterus tissue, oxytocin binds to one receptor site with a measured strength and amount.

    Peptide
    Oxytocin
    Outcome
    Not applicableOxytocin binding affinity and receptor concentration in possum uterus
    Study

    brushtail possumn = 5

    uterine tissue, radioreceptor assay
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    Dose not stated

    Measurements

    Kd
    3 nmol/l
    possum uterus
    Ro
    200 fmol/mg protein
    possum uterus

    Source sentences

    Summary
    A single oxytocin binding site was found with an affinity (Kd) and receptor concentration (Ro) of 3.0 +/- 0.8 nmol/l and 200 +/- 60 fmol/mg protein, respectively (SEM; n = 5).
    1 context sentence
    Summary · context
    Oxytocin receptors in the uterus of the brushtail possum (T. vulpecula) were characterized by radioreceptor assay and compared with those of the sheep and rat uterus.
  2. 02LabEx vivo tissueActivity measurement

    In competitive displacement curves, the possum uterine receptor showed specificity vasotocin greater than oxytocin greater than mesotocin and arginine-vasopressin.

    In plain wordsIn possum uterus tissue, the oxytocin receptor bound vasotocin best, then oxytocin, then related peptides.

    Peptide
    Oxytocin
    Outcome
    Not applicableLigand specificity of possum uterine oxytocin receptor
    Study

    brushtail possumn: not reported in source

    uterine tissue, radioreceptor assay
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Competitive displacement curves with related peptides showed the following order of specificity: vasotocin greater than oxytocin greater than mesotocin = arginine-vasopressin = [Thr4, Gly7]-oxytocin greater than lysine-vasopressin = isotocin much greater than [d(CH2)5, D-Phe2, Ile4, Ala9-NH2]-AVP.
    1 context sentence
    Summary · context
    Oxytocin receptors in the uterus of the brushtail possum (T. vulpecula) were characterized by radioreceptor assay and compared with those of the sheep and rat uterus.

Studies that did not test the peptide alone1

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

  1. 03LabNot a test of Oxytocin aloneEx vivo tissueOther

    The possum uterine oxytocin receptor was stable at -20 degrees C and needed divalent ions for optimum binding; this is a property of the assay and receptor, not an effect of oxytocin.

    In plain wordsIn possum uterus tissue, the oxytocin receptor stayed stable when frozen and needed certain ions to bind well.

    Peptide
    Oxytocin
    Outcome
    Not applicableStability and ion requirement of possum uterine oxytocin receptor
    Study

    brushtail possumn: not reported in source

    uterine tissue, radioreceptor assay
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health

    Source sentences

    Summary
    The receptor was stable at -20 degrees C; divalent ions were required for optimum binding.
    1 context sentence
    Summary · context
    Oxytocin receptors in the uterus of the brushtail possum (T. vulpecula) were characterized by radioreceptor assay and compared with those of the sheep and rat uterus.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:52 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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