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Study · Animal study (in vivo) · rat · 1990

6 results

Respiratory and locomotor stimulation by low doses of dermorphin, a mu1 receptor-mediated effect.

Paakkari P, Paakkari I, Sirén AL, Feuerstein G

The Journal of pharmacology and experimental therapeutics1 Jan 1990Cited by 33 (Europe PMC)

PMID1967644 (opens in a new tab)DOI10.1016/s0022-3565(25)13335-1 (opens in a new tab)PepBankPUB-01967644
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Activity measurement

    In rats, dermorphin increased locomotor activity dose dependently at 10 to 100 pmol/kg.

    In plain wordsIn rats, dermorphin increased movement with increasing doses from 10 to 100 pmol/kg.

    Peptide
    Dermorphin
    Outcome
    IncreaseLow-dose locomotor activity
    Study

    ratn: not reported in source

    Rats
    Outcome group
    Exercise and physical function · Nervous system and cognition
    Studied dose
    10 to 100 pmol/kg · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    The selective opioid mu receptor agonist dermorphin increased the locomotor activity of rats dose dependently at 10 to 100 pmol/kg i.c.v.
  2. 02AnimalAnimal study (in vivo)Activity measurement

    In rats, low-dose dermorphin increased respiratory rate independently of locomotor activity changes.

    In plain wordsIn rats, low-dose dermorphin increased breathing rate independently of movement changes.

    Peptide
    Dermorphin
    Outcome
    IncreaseLow-dose respiratory rate
    Study

    ratn: not reported in source

    Rats
    Outcome group
    Respiratory function · Respiratory
    Studied dose
    10 to 100 pmol/kg · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    Respiratory rate, relative tidal volume and respiratory minute volume also increased unrelated to changes in locomotor activity.
  3. 03AnimalAnimal study (in vivo)Activity measurement

    In rats, low-dose dermorphin increased relative tidal volume independently of locomotor activity changes.

    In plain wordsIn rats, low-dose dermorphin increased relative breath volume independently of movement changes.

    Peptide
    Dermorphin
    Outcome
    IncreaseLow-dose relative tidal volume
    Study

    ratn: not reported in source

    Rats
    Outcome group
    Respiratory function · Respiratory
    Studied dose
    10 to 100 pmol/kg · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    Respiratory rate, relative tidal volume and respiratory minute volume also increased unrelated to changes in locomotor activity.
  4. 04AnimalAnimal study (in vivo)Activity measurement

    In rats, low-dose dermorphin increased respiratory minute volume independently of locomotor activity changes.

    In plain wordsIn rats, low-dose dermorphin increased breathing volume per minute independently of movement changes.

    Peptide
    Dermorphin
    Outcome
    IncreaseLow-dose respiratory minute volume
    Study

    ratn: not reported in source

    Rats
    Outcome group
    Respiratory function · Respiratory
    Studied dose
    10 to 100 pmol/kg · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    Respiratory rate, relative tidal volume and respiratory minute volume also increased unrelated to changes in locomotor activity.
  5. 05AnimalAnimal study (in vivo)Safety outcome

    In rats, higher dermorphin doses produced catalepsy.

    In plain wordsIn rats, higher dermorphin doses produced catalepsy.

    Peptide
    Dermorphin
    Outcome
    IncreaseHigh-dose catalepsy
    Study

    ratn: not reported in source

    Rats
    Outcome group
    Adverse events · Nervous system and cognition
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    Higher doses, on the other hand, produced catalepsy and respiratory depression.
  6. 06AnimalAnimal study (in vivo)Safety outcome

    In rats, higher dermorphin doses produced respiratory depression.

    In plain wordsIn rats, higher dermorphin doses depressed breathing.

    Peptide
    Dermorphin
    Outcome
    DecreaseHigh-dose respiratory depression
    Study

    ratn: not reported in source

    Rats
    Outcome group
    Adverse events · Respiratory
    Studied dose
    Dose not stated · intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    Higher doses, on the other hand, produced catalepsy and respiratory depression.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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