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Study · Animal study (in vivo) · rat · 1991

3 results

Robust growth hormone (GH) secretion in aged female rats co-administered GH-releasing hexapeptide (GHRP-6) and GH-releasing hormone (GHRH).

Walker RF, Yang SW, Bercu BB

Life sciences1 Jan 1991Cited by 20 (Europe PMC)

PMID1943453 (opens in a new tab)DOI10.1016/0024-3205(91)90050-l (opens in a new tab)PepBankPUB-01943453
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In female rats, the plasma GH response to GHRP‑6 alone was lower in old than young animals.

    In plain wordsIn female rats, GHRP‑6 alone stimulated less GH release in old than young rats.

    Peptide
    GHRP-6
    Outcome
    DecreaseGH response by age
    Study

    ratn: not reported in source

    anesthetized female Fischer 344 rats
    Comparator
    Young rats
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    30 micrograms/kgAs given in this study (rat).

    Source sentences

    Summary
    The increase in plasma GH as a function of time following administration of GHRP-6 was lower (p less than 0.001) in old rats than in young rats
    1 context sentence
    Summary · context
    GHRP-6 (30 micrograms/kg) was administered alone or in combination with GHRH (2 micrograms/kg) to anesthetized female Fischer 344 rats, 3 or 19 months of age.

Studies that did not test the peptide alone2

In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-6.

  1. 02AnimalNot a test of GHRP-6 aloneAnimal study (in vivo)Efficacy outcome

    In female rats, GHRP‑6 plus GHRH produced a higher plasma GH response in old than young animals.

    In plain wordsIn female rats, GHRP‑6 plus GHRH produced more GH release in old than young rats.

    Peptide
    GHRP-6
    Outcome
    IncreaseCombined GH response by age
    Study

    ratn: not reported in source

    anesthetized female Fischer 344 rats
    Comparator
    Young rats
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Measurements

    Mean Cmax
    8539 micrograms/l
    old rats
    Mean Cmax
    2970 micrograms/l
    young rats

    Source sentences

    Summary
    whereas the increase in plasma GH secretion as a function of time following co-administration of GHRP-6 and GHRH was higher (p less than 0.001) in old rats than in young rats (mean Cmax = 8539 +/- 790.6 micrograms/l vs. 2970 +/- 866 micrograms/l, respectively; p less than 0.01).
    1 context sentence
    Summary · context
    GHRP-6 (30 micrograms/kg) was administered alone or in combination with GHRH (2 micrograms/kg) to anesthetized female Fischer 344 rats, 3 or 19 months of age.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

  2. 03AnimalNot a test of GHRP-6 aloneAnimal study (in vivo)Efficacy outcome

    In female rats studied for GHRP‑6 responses, pituitary GH concentrations were lower in old than young animals.

    In plain wordsIn female rats studied for GHRP‑6 responses, old rats had lower pituitary GH levels than young rats.

    Peptide
    GHRP-6
    Outcome
    DecreasePituitary GH by age
    Study

    ratn: not reported in source

    anesthetized female Fischer 344 rats
    Comparator
    Young rats
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Measurements

    Pituitary GH
    257 micrograms/mg wet wt.
    old
    Pituitary GH
    639.7 micrograms/mg wet wt.
    young

    Source sentences

    Summary
    Since pituitary GH concentrations in old rats were lower than in young rats (257.0 +/- 59.8 micrograms/mg wet wt. vs. 639.7 +/- 149.2 micrograms/mg wet wt., respectively; p less than 0.03)
    1 context sentence
    Summary · context
    GHRP-6 (30 micrograms/kg) was administered alone or in combination with GHRH (2 micrograms/kg) to anesthetized female Fischer 344 rats, 3 or 19 months of age.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:59 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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