Skip to content

Study · Measured the body's own peptide · 1991

3 results

Impact of ether anesthesia on the hypophyseal content of oxytocin neurophysin I and II: a comparative study with ketamine in the rat.

Zierer R

Life sciences1 Jan 1991Cited by 3 (Europe PMC)

PMID1943445 (opens in a new tab)DOI10.1016/0024-3205(91)90390-w (opens in a new tab)PepBankPUB-01943445
Publisher pagePubMedAsk about this study
Jump to 3 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Natural levels measured3

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01AnimalEndogenous levelAnimal study (in vivo)Other

    In rats, anesthesia before sacrifice was linked with lower concentrations of posterior pituitary neuropeptides, including oxytocin, than in guillotine-killed controls.

    In plain wordsIn rats, anesthetized animals had less of the body's own oxytocin and related proteins in the pituitary gland than controls.

    Peptide
    Oxytocin
    Outcome
    DecreasePosterior pituitary oxytocin content after anesthesia
    Study

    ratn: not reported in source

    Comparator
    Guillotine-killed controls
    Outcome group
    Hormone levels · Endocrine and hormones

    Source sentences

    Summary
    animals anesthetized with either prior to sacrifice had a decreased concentration of neuropeptides per PP
    1 context sentence
    Summary · context
    Rats were treated with either a combination of atropine (0.87 mg/kg) and diphenylhydantoin (85 mg/kg) and then anesthetized with ketamine (42 mg/kg) or were directly anesthetized with diethyl-ether, and then killed.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  2. 02AnimalEndogenous levelAnimal study (in vivo)Other

    In rats, blood oxytocin was 1.6 times higher in anesthetized animals than in animals given the drug combination or killed directly with a guillotine.

    In plain wordsIn rats, the body's own oxytocin in blood was higher in anesthetized animals than in control animals.

    Peptide
    Oxytocin
    Outcome
    IncreaseBlood oxytocin concentration after anesthesia
    Study

    ratn: not reported in source

    Comparator
    Drug combination or guillotine
    Outcome group
    Hormone levels · Endocrine and hormones

    Measurements

    Blood OT fold difference
    1.6 times
    anesthetized versus controls

    Source sentences

    Summary
    the blood concentration of OT was 1.6 times higher than in animals treated with the drug combination or killed directly with a guillotine.
    1 context sentence
    Summary · context
    Rats were treated with either a combination of atropine (0.87 mg/kg) and diphenylhydantoin (85 mg/kg) and then anesthetized with ketamine (42 mg/kg) or were directly anesthetized with diethyl-ether, and then killed.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  3. 03AnimalEndogenous levelAnimal study (in vivo)Other

    In rats, animals given atropine and diphenylhydantoin before sacrifice had oxytocin concentrations similar to guillotine-killed animals.

    In plain wordsIn rats, the drug combination alone did not change the body's own oxytocin levels compared with controls.

    Peptide
    Oxytocin
    Outcome
    No significant changeOxytocin after drug combination versus guillotine
    Study

    ratn: not reported in source

    Comparator
    Guillotine-killed controls
    Outcome group
    Hormone levels · Endocrine and hormones

    Source sentences

    Summary
    animals killed with a guillotine or being medicated with our drug combination prior to sacrifice had similar concentrations of OT, OTNP-I and OTNP-II per PP and ml of blood
    1 context sentence
    Summary · context
    Rats were treated with either a combination of atropine (0.87 mg/kg) and diphenylhydantoin (85 mg/kg) and then anesthetized with ketamine (42 mg/kg) or were directly anesthetized with diethyl-ether, and then killed.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:52 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.