Intranasal administration of His-D-Trp-Ala-Trp-D-Phe-LysNH2 (growth hormone releasing peptide) increased plasma growth hormone and insulin-like growth factor-I levels in normal men.

Hayashi S, Okimura Y, Yagi H, Uchiyama T, Takeshima Y, Shakutsui S, Oohashi S, Bowers CY, Chihara K

Endocrinologia japonica1 Feb 1991Cited by 29 (Europe PMC)

PMID1915110DOI10.1507/endocrj1954.38.15PepBankPUB-01915110

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study15

15 results from studies that gave the peptide. 15 results from people.

01HumanNon-randomized trialEfficacy outcome
In healthy men, an intravenous GHRP bolus caused a remarkable increase in plasma GH.
In plain wordsIn healthy men, an injected dose of GHRP caused a large rise in growth hormone.
Peptide
GHRP-6
Outcome
IncreasePlasma GH peak after intravenous GHRP bolus
Study
n = 6
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
1 microgram/kg body weight · intravenousAs given in this study (human).
Measurements
Mean peak GH
54.9 micrograms/L
intravenous GHRP
Source sentences
Summary
An iv bolus injection of GHRP(1 micrograms/kg BW) caused a remarkable increase in plasma GH levels with a mean (+/- SE) peak of 54.9 +/- 4.2-micrograms/L.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of intranasal and iv administration of His-D-Trp-Ala-Trp-D-Phe-LysNH2 (GHRP) on plasma GH, PRL, LH, FSH, TSH, cortisol, insulin, IGF-I as well as GHRH-like immunoreactivity (LI) levels were examined in 6 healthy male subjects.
Report a problemFND-0191511001
02HumanNon-randomized trialEfficacy outcome
In healthy men, intranasal GHRP at 30 micrograms/kg produced a significant, dose-related increase in plasma GH.
In plain wordsIn healthy men, GHRP given as a nasal spray raised growth hormone, and a higher dose gave a bigger rise.
Peptide
GHRP-6
Outcome
IncreasePlasma GH peak after intranasal GHRP 30 micrograms/kg
Study
n = 6
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
30 micrograms/kg body weight · intranasalAs given in this study (human).
Measurements
Peak GH
39.6 micrograms/L
30 micrograms/kg intranasal
Source sentences
Summary
In addition an intranasal administration of GHRP resulted in a significant, dose-related increase in plasma GH with peaks of 39.6 +/- 15.3 micrograms/L at a dose of 30 micrograms/kg BW, 14.1 +/- 5.0 micrograms/L at 15 micrograms/kg BW and 7.5 +/- 5.7 micrograms/L at 5 microgram/kg BW.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of intranasal and iv administration of His-D-Trp-Ala-Trp-D-Phe-LysNH2 (GHRP) on plasma GH, PRL, LH, FSH, TSH, cortisol, insulin, IGF-I as well as GHRH-like immunoreactivity (LI) levels were examined in 6 healthy male subjects.
Report a problemFND-0191511002
03HumanNon-randomized trialEfficacy outcome
In healthy men, intranasal GHRP at 15 micrograms/kg produced a significant, dose-related increase in plasma GH.
In plain wordsIn healthy men, GHRP given as a nasal spray raised growth hormone, and a higher dose gave a bigger rise.
Peptide
GHRP-6
Outcome
IncreasePlasma GH peak after intranasal GHRP 15 micrograms/kg
Study
n = 6
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
15 micrograms/kg body weight · intranasalAs given in this study (human).
Measurements
Peak GH
14.1 micrograms/L
15 micrograms/kg intranasal
Source sentences
Summary
In addition an intranasal administration of GHRP resulted in a significant, dose-related increase in plasma GH with peaks of 39.6 +/- 15.3 micrograms/L at a dose of 30 micrograms/kg BW, 14.1 +/- 5.0 micrograms/L at 15 micrograms/kg BW and 7.5 +/- 5.7 micrograms/L at 5 microgram/kg BW.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of intranasal and iv administration of His-D-Trp-Ala-Trp-D-Phe-LysNH2 (GHRP) on plasma GH, PRL, LH, FSH, TSH, cortisol, insulin, IGF-I as well as GHRH-like immunoreactivity (LI) levels were examined in 6 healthy male subjects.
Report a problemFND-0191511003
04HumanNon-randomized trialEfficacy outcome
In healthy men, intranasal GHRP at 5 micrograms/kg produced a significant, dose-related increase in plasma GH.
In plain wordsIn healthy men, GHRP given as a nasal spray raised growth hormone, and a higher dose gave a bigger rise.
Peptide
GHRP-6
Outcome
IncreasePlasma GH peak after intranasal GHRP 5 micrograms/kg
Study
n = 6
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
5 micrograms/kg body weight · intranasalAs given in this study (human).
Measurements
Peak GH
7.5 micrograms/L
5 micrograms/kg intranasal
Source sentences
Summary
In addition an intranasal administration of GHRP resulted in a significant, dose-related increase in plasma GH with peaks of 39.6 +/- 15.3 micrograms/L at a dose of 30 micrograms/kg BW, 14.1 +/- 5.0 micrograms/L at 15 micrograms/kg BW and 7.5 +/- 5.7 micrograms/L at 5 microgram/kg BW.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of intranasal and iv administration of His-D-Trp-Ala-Trp-D-Phe-LysNH2 (GHRP) on plasma GH, PRL, LH, FSH, TSH, cortisol, insulin, IGF-I as well as GHRH-like immunoreactivity (LI) levels were examined in 6 healthy male subjects.
Report a problemFND-0191511004
05HumanNon-randomized trialEfficacy outcome
In healthy men, intravenous GHRP slightly but significantly increased plasma PRL.
In plain wordsIn healthy men, injected GHRP slightly raised blood prolactin.
Peptide
GHRP-6
Outcome
IncreasePlasma PRL after intravenous GHRP
Study
n = 6
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
1 microgram/kg body weight · intravenousAs given in this study (human).
Source sentences
Summary
Plasma PRL and cortisol levels were slightly but significantly increased after iv administration of GHRP
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of intranasal and iv administration of His-D-Trp-Ala-Trp-D-Phe-LysNH2 (GHRP) on plasma GH, PRL, LH, FSH, TSH, cortisol, insulin, IGF-I as well as GHRH-like immunoreactivity (LI) levels were examined in 6 healthy male subjects.
Report a problemFND-0191511005
06HumanNon-randomized trialEfficacy outcome
In healthy men, intravenous GHRP slightly but significantly increased plasma cortisol.
In plain wordsIn healthy men, injected GHRP slightly raised blood cortisol.
Peptide
GHRP-6
Outcome
IncreasePlasma cortisol after intravenous GHRP
Study
n = 6
Outcome group
Stress hormones · Endocrine and hormones
Studied dose
1 microgram/kg body weight · intravenousAs given in this study (human).
Source sentences
Summary
Plasma PRL and cortisol levels were slightly but significantly increased after iv administration of GHRP
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of intranasal and iv administration of His-D-Trp-Ala-Trp-D-Phe-LysNH2 (GHRP) on plasma GH, PRL, LH, FSH, TSH, cortisol, insulin, IGF-I as well as GHRH-like immunoreactivity (LI) levels were examined in 6 healthy male subjects.
Report a problemFND-0191511006
07HumanNon-randomized trialSafety outcome
In healthy men, GHRP failed to affect plasma TSH.
In plain wordsIn healthy men, GHRP did not change blood TSH.
Peptide
GHRP-6
Outcome
No significant changePlasma TSH after GHRP
Study
n = 6
Outcome group
Thyroid function · Endocrine and hormones
Studied dose
Dose not stated
Source sentences
Summary
GHRP totally failed to affect plasma TSH, LH, FSH, insulin, blood sugar and GHRH-LI levels.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of intranasal and iv administration of His-D-Trp-Ala-Trp-D-Phe-LysNH2 (GHRP) on plasma GH, PRL, LH, FSH, TSH, cortisol, insulin, IGF-I as well as GHRH-like immunoreactivity (LI) levels were examined in 6 healthy male subjects.
Report a problemFND-0191511007
08HumanNon-randomized trialSafety outcome
In healthy men, GHRP failed to affect plasma LH.
In plain wordsIn healthy men, GHRP did not change blood LH.
Peptide
GHRP-6
Outcome
No significant changePlasma LH after GHRP
Study
n = 6
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated
Source sentences
Summary
GHRP totally failed to affect plasma TSH, LH, FSH, insulin, blood sugar and GHRH-LI levels.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of intranasal and iv administration of His-D-Trp-Ala-Trp-D-Phe-LysNH2 (GHRP) on plasma GH, PRL, LH, FSH, TSH, cortisol, insulin, IGF-I as well as GHRH-like immunoreactivity (LI) levels were examined in 6 healthy male subjects.
Report a problemFND-0191511008
09HumanNon-randomized trialSafety outcome
In healthy men, GHRP failed to affect plasma FSH.
In plain wordsIn healthy men, GHRP did not change blood FSH.
Peptide
GHRP-6
Outcome
No significant changePlasma FSH after GHRP
Study
n = 6
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
Dose not stated
Source sentences
Summary
GHRP totally failed to affect plasma TSH, LH, FSH, insulin, blood sugar and GHRH-LI levels.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of intranasal and iv administration of His-D-Trp-Ala-Trp-D-Phe-LysNH2 (GHRP) on plasma GH, PRL, LH, FSH, TSH, cortisol, insulin, IGF-I as well as GHRH-like immunoreactivity (LI) levels were examined in 6 healthy male subjects.
Report a problemFND-0191511009
10HumanNon-randomized trialSafety outcome
In healthy men, GHRP failed to affect plasma insulin.
In plain wordsIn healthy men, GHRP did not change blood insulin.
Peptide
GHRP-6
Outcome
No significant changePlasma insulin after GHRP
Study
n = 6
Outcome group
Glycemic control · Metabolic and weight
Studied dose
Dose not stated
Source sentences
Summary
GHRP totally failed to affect plasma TSH, LH, FSH, insulin, blood sugar and GHRH-LI levels.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of intranasal and iv administration of His-D-Trp-Ala-Trp-D-Phe-LysNH2 (GHRP) on plasma GH, PRL, LH, FSH, TSH, cortisol, insulin, IGF-I as well as GHRH-like immunoreactivity (LI) levels were examined in 6 healthy male subjects.
Report a problemFND-0191511010
11HumanNon-randomized trialSafety outcome
In healthy men, GHRP failed to affect blood sugar.
In plain wordsIn healthy men, GHRP did not change blood sugar.
Peptide
GHRP-6
Outcome
No significant changeBlood sugar after GHRP
Study
n = 6
Outcome group
Glycemic control · Metabolic and weight
Studied dose
Dose not stated
Source sentences
Summary
GHRP totally failed to affect plasma TSH, LH, FSH, insulin, blood sugar and GHRH-LI levels.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of intranasal and iv administration of His-D-Trp-Ala-Trp-D-Phe-LysNH2 (GHRP) on plasma GH, PRL, LH, FSH, TSH, cortisol, insulin, IGF-I as well as GHRH-like immunoreactivity (LI) levels were examined in 6 healthy male subjects.
Report a problemFND-0191511011
12HumanNon-randomized trialMechanism
In healthy men, GHRP failed to affect plasma GHRH-like immunoreactivity.
In plain wordsIn healthy men, GHRP did not change blood levels of GHRH-like material.
Peptide
GHRP-6
Outcome
No significant changePlasma GHRH-like immunoreactivity after GHRP
Study
n = 6
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
Dose not stated
Source sentences
Summary
GHRP totally failed to affect plasma TSH, LH, FSH, insulin, blood sugar and GHRH-LI levels.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of intranasal and iv administration of His-D-Trp-Ala-Trp-D-Phe-LysNH2 (GHRP) on plasma GH, PRL, LH, FSH, TSH, cortisol, insulin, IGF-I as well as GHRH-like immunoreactivity (LI) levels were examined in 6 healthy male subjects.
Report a problemFND-0191511012
13HumanNon-randomized trialSafety outcome
In healthy men, seven consecutive intranasal GHRP administrations at 15 micrograms/kg every 8 h were well tolerated.
In plain wordsIn healthy men, seven nasal doses of GHRP given every 8 hours were well tolerated.
Peptide
GHRP-6
Outcome
No significant changeTolerability of repeated intranasal GHRP
Study
n = 6
Outcome group
Adverse events · Whole body
Studied dose
15 micrograms/kg body weight · intranasal · seven administrations every 8 hAs given in this study (human).
Source sentences
Summary
Seven consecutive, intranasal administrations of 15 micrograms/kg BW GHRP every 8h were well tolerated in all subjects examined.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of intranasal and iv administration of His-D-Trp-Ala-Trp-D-Phe-LysNH2 (GHRP) on plasma GH, PRL, LH, FSH, TSH, cortisol, insulin, IGF-I as well as GHRH-like immunoreactivity (LI) levels were examined in 6 healthy male subjects.
Report a problemFND-0191511013
14HumanNon-randomized trialEfficacy outcome
In healthy men, GH responsiveness to GHRP was not attenuated by desensitization during repeated intranasal dosing.
In plain wordsIn healthy men, repeated nasal GHRP doses kept raising growth hormone and the response did not fade.
Peptide
GHRP-6
Outcome
No significant changeGH responsiveness to GHRP during repeated administration
Study
n = 6
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
15 micrograms/kg body weight · intranasal · seven administrations every 8 hAs given in this study (human).
Source sentences
Summary
During this treatment, GH responsiveness to GHRP was not attenuated by desensitization
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of intranasal and iv administration of His-D-Trp-Ala-Trp-D-Phe-LysNH2 (GHRP) on plasma GH, PRL, LH, FSH, TSH, cortisol, insulin, IGF-I as well as GHRH-like immunoreactivity (LI) levels were examined in 6 healthy male subjects.
Report a problemFND-0191511014
15HumanNon-randomized trialEfficacy outcome
In healthy men, plasma IGF-I increased after repeated intranasal GHRP administration.
In plain wordsIn healthy men, repeated nasal GHRP doses raised blood IGF-I.
Peptide
GHRP-6
Outcome
IncreasePlasma IGF-I after repeated GHRP administration
Study
n = 6
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
15 micrograms/kg body weight · intranasal · seven administrations every 8 hAs given in this study (human).
Measurements
IGF-I
94.5 micrograms/L
before GHRP
IGF-I
125.8 micrograms/L
after repeated GHRP
Source sentences
Summary
plasma IGF-I was increased from 94.5 +/- 5.8 micrograms/L before GHRP to 125.8 +/- 6.0 micrograms/L after repeated GHRP administration.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of intranasal and iv administration of His-D-Trp-Ala-Trp-D-Phe-LysNH2 (GHRP) on plasma GH, PRL, LH, FSH, TSH, cortisol, insulin, IGF-I as well as GHRH-like immunoreactivity (LI) levels were examined in 6 healthy male subjects.
Report a problemFND-0191511015

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
12 Oct 2026, 12:58 UTC
Study results updated
Version 1
9 Oct 2026, 03:13 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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