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Study · In vitro (cell-free) · 1991

1 result

Characterization of estrogen and antiestrogen binding to the cytosol and microsomes of breast tumors.

Lopes MC, Tavares MC, Vale MG, Carvalho AP

The Journal of steroid biochemistry and molecular biology1 Sept 1991Cited by 2 (Europe PMC)

PMID1911424 (opens in a new tab)DOI10.1016/0960-0760(91)90045-7 (opens in a new tab)PepBankPUB-01911424
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cell-free)Activity measurement

    In human breast tumor fractions, enclomiphene displaced estradiol with identical IC50 values in cytosol and microsomal membranes.

    In plain wordsIn lab tests on human breast tumors, enclomiphene displaced estradiol equally in cytosol and microsomal membranes.

    Peptide
    Enclomiphene
    Outcome
    No significant changeEstradiol displacement IC50
    Study

    humann: not reported in source

    breast tumor cytosol and microsomal membranes
    Comparator
    cytosol versus microsomal membranes
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The displacement of [3H]estradiol with unlabeled hormone or with the antiestrogens, nafoxidine, enclomiphene and tamoxifen (TAM) exhibits identical IC50 values either in the cytosol or in the microsomal membranes.
    1 context sentence
    Summary · context
    The binding of [3H]estradiol and [3H]hydroxytamoxifen to the cytosol and microsomal fractions of several human breast tumors was investigated.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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