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Study · Not a test of the peptide alone · 1991

4 results

Induction of thymocyte proliferation by supernatants from a mouse thymic epithelial cell line.

Villa-Verde DM, Defresne MP, Greimers R, Dardenne M, Savino W, Boniver J

Cellular immunology1 Aug 1991Cited by 11 (Europe PMC)

PMID1905586 (opens in a new tab)DOI10.1016/0008-8749(91)90386-p (opens in a new tab)PepBankPUB-01905586
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone4

In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymulin (serum thymic factor).

  1. 01LabNot a test of Thymulin (serum thymic factor) aloneIn vitro (cells)Mechanism

    In mouse thymocytes, thymic epithelial cell supernatants induced proliferation.

    In plain wordsIn lab tests, mouse thymic cell supernatants increased thymocyte multiplication.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseThymocyte proliferation with epithelial supernatant
    Study

    mousen: not reported in source

    Mouse thymocytes exposed to IT-76M1 thymic epithelial cell supernatants
    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    Treating mouse thymocytes by supernatants from one of TEC line (IT-76M1), we observed an induction of thymocyte proliferation and an increase in the percentages of CD4-/CD8- thymocytes.

    In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).

  2. 02LabNot a test of Thymulin (serum thymic factor) aloneIn vitro (cells)Mechanism

    In mouse thymocytes, thymic epithelial cell supernatants increased the percentage of CD4-/CD8- cells.

    In plain wordsIn lab tests, mouse thymic cell supernatants increased the share of thymocytes lacking CD4 and CD8.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseDouble-negative thymocyte percentage
    Study

    mousen: not reported in source

    Mouse thymocytes exposed to IT-76M1 thymic epithelial cell supernatants
    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    Treating mouse thymocytes by supernatants from one of TEC line (IT-76M1), we observed an induction of thymocyte proliferation and an increase in the percentages of CD4-/CD8- thymocytes.

    In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).

  3. 03LabNot a test of Thymulin (serum thymic factor) aloneIn vitro (cells)Mechanism

    In mouse thymocytes, an anti-thymulin antibody largely inhibited proliferation induced by epithelial cell supernatants.

    In plain wordsIn lab tests, a thymulin-blocking antibody reduced mouse thymocyte multiplication compared with supernatants alone.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    DecreaseProliferation with anti-thymulin antibody
    Study

    mousen: not reported in source

    Mouse thymocytes exposed to IT-76M1 thymic epithelial cell supernatants
    Comparator
    Supernatants without anti-thymulin antibody
    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    This proliferation was largely inhibited when thymocytes were incubated with IT-76M1 supernatants together with an anti-thymulin monoclonal antibody, but could be enhanced by pretreating growing epithelial cells by triiodothyronine.

    In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).

  4. 04LabNot a test of Thymulin (serum thymic factor) aloneIn vitro (cells)Mechanism

    In mouse thymocyte cultures, triiodothyronine pretreatment of epithelial cells enhanced supernatant-induced proliferation.

    In plain wordsIn lab tests, thyroid hormone pretreatment of mouse epithelial cells increased the multiplication induced by their supernatants.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseProliferation with thyroid hormone pretreatment
    Study

    mousen: not reported in source

    Mouse thymocytes exposed to IT-76M1 thymic epithelial cell supernatants
    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    This proliferation was largely inhibited when thymocytes were incubated with IT-76M1 supernatants together with an anti-thymulin monoclonal antibody, but could be enhanced by pretreating growing epithelial cells by triiodothyronine.

    In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 2

    21 Oct 2026, 13:55 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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