In patients with leiomyomas, vaginal hysterectomy occurred in 76.0% with leuprolide versus 16% without preoperative agonist.
In plain wordsIn patients with fibroids, vaginal hysterectomy was more common with leuprolide than without preoperative agonist.
- Peptide
- Leuprolide
- Outcome
- IncreaseVaginal hysterectomy
- Study
n = 50
- Comparator
- No preoperative agonist
- Outcome group
- Surgical outcomes · Reproductive and sexual health
- Studied dose
- Dose not stated · 2 monthsAs given in this study (human).
Measurements
- Vaginal hysterectomy
- 76%
- leuprolide
- Vaginal hysterectomy
- 16%
- control
Source sentences
Patients in group B had an increase in hemoglobin levels (10.75 to 12.12 gm/dl, p less than 0.05) and a decrease in uterine volume (1086.7 to 723.4 ml, p less than 0.05) after 8 weeks of agonist therapy and were more likely to undergo vaginal hysterectomy (76.0% vs 16%).
2 context sentences(design, population, supporting numbers)
Fifty premenopausal patients requiring hysterectomy as treatment for symptomatic uterine leiomyomas, which were the size of 14 to 18 weeks' gestation, were randomized into two groups to determine whether preoperative gonadotropin-releasing hormone agonist would increase the feasibility of vaginal ra…
The control group (group A; n = 25) did not receive preoperative gonadotropin-releasing hormone agonist, but patients in Group B (n = 25) received 2 months of gonadotropin-releasing hormone agonist before undergoing hysterectomy.