In COS cells, the basic amino acid cluster within the thymosin alpha‑1 sequence of prothymosin alpha did not cause nuclear transport.
In plain wordsIn cells, the thymosin alpha‑1 part of prothymosin alpha did not move the protein into the nucleus.
- Peptide
- Thymosin alpha-1
- Outcome
- No significant changeNuclear targeting by the thymosin alpha 1 sequence
- Study
n: not reported in source
COS cells transfected with human prothymosin alpha constructs- Outcome group
- Receptor activity and mechanism · Immune and inflammation
Source sentences
whereas the basic cluster of amino acids situated within the thymosin alpha 1 sequence at the amino terminus failed to effect nuclear transport.
1 context sentence(design, population, supporting numbers)
2) Constructs in which human prothymosin alpha nucleic acid sequences were fused in-frame either near the amino terminus of the beta-galactosidase gene in pCH110 or at the carboxyl terminus, when expressed in COS cells, resulted in nuclear localization of the fusion protein; indirect immunofluorescence in situ was used as the assay.
In this study, Thymosin alpha-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin alpha-1.