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Study · Measured the body's own peptide · 1991

4 results

Thymic peptides, stress, and depressive symptoms in older men: a comparison of different statistical techniques for small samples.

Aldwin CM, Spiro A 3rd, Clark G, Hall N

Brain, behavior, and immunity1 Jun 1991Cited by 4 (Europe PMC)

PMID1893220 (opens in a new tab)DOI10.1016/0889-1591(91)90017-5 (opens in a new tab)PepBankPUB-01893220
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Natural levels measured4

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelObservational studyOther

    In older men, natural thymosin alpha‑1 levels did not correlate significantly with life events or depressive symptoms at baseline, before a glucose challenge.

    In plain wordsIn older men, the body's own thymosin alpha‑1 levels were not linked to stress or depressive symptoms before the glucose challenge.

    Peptide
    Thymosin alpha-1
    Outcome
    No significant changeCorrelation of thymosin alpha 1 with life events and depressive symptoms at baseline
    Study

    n = 18

    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    While none of the correlations reached significance in the baseline condition
    1 context sentence
    Summary · context
    The sample consisted of 18 men, aged 48-80, participants in the Normative Aging Study.

    This result measures the body's own Thymosin alpha-1. Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelObservational studyOther

    In older men, natural thymosin alpha‑1 levels after a glucose challenge correlated positively and significantly with life events.

    In plain wordsIn older men, the body's own thymosin alpha‑1 levels after a glucose challenge were linked to more stressful life events.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseCorrelation of postchallenge thymosin alpha 1 with life events
    Study

    n = 18

    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    While none of the correlations reached significance in the baseline condition, life events and depressive symptoms were significantly correlated with TSN-alpha 1 in the postchallenge condition (r's = .57, and .62, respectively).
    1 context sentence
    Summary · context
    The sample consisted of 18 men, aged 48-80, participants in the Normative Aging Study.

    This result measures the body's own Thymosin alpha-1. Nobody was given the peptide. It is not evidence about taking it.

  3. 03HumanEndogenous levelObservational studyOther

    In older men, natural thymosin alpha‑1 levels after a glucose challenge correlated positively and significantly with depressive symptoms.

    In plain wordsIn older men, the body's own thymosin alpha‑1 levels after a glucose challenge were linked to more depressive symptoms.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreaseCorrelation of postchallenge thymosin alpha 1 with depressive symptoms
    Study

    n = 18

    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    While none of the correlations reached significance in the baseline condition, life events and depressive symptoms were significantly correlated with TSN-alpha 1 in the postchallenge condition (r's = .57, and .62, respectively).
    1 context sentence
    Summary · context
    The sample consisted of 18 men, aged 48-80, participants in the Normative Aging Study.

    This result measures the body's own Thymosin alpha-1. Nobody was given the peptide. It is not evidence about taking it.

  4. 04HumanEndogenous levelObservational studyOther

    In older men, those high in both life events and depression showed the highest natural thymosin alpha‑1 levels after a glucose challenge; the psychosocial variables accounted for 65% of the variance.

    In plain wordsIn older men, those with both many stressful events and depression had the highest body's own thymosin alpha‑1 levels after a glucose challenge.

    Peptide
    Thymosin alpha-1
    Outcome
    IncreasePostchallenge thymosin alpha 1 in men high in both life events and depression
    Study

    n = 18

    Outcome group
    Immune response · Immune and inflammation

    Measurements

    Variance explained by psychosocial variables
    65%
    postchallenge TSN-alpha 1

    Source sentences

    Summary
    Hierarchical regression analyses with cross-product interaction terms suggested that individuals who were high in both life events and depression showed the highest levels of postchallenge TSN-alpha 1, with the psychosocial variables accounting for 65% of the variance.
    2 context sentences
    Summary · context
    Given the small sample size, we replicated these analyses using jackknife and bootstrap techniques, which generally confirmed these findings.
    Summary · context
    The sample consisted of 18 men, aged 48-80, participants in the Normative Aging Study.

    This result measures the body's own Thymosin alpha-1. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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