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Study · Animal study (in vivo) · mouse · 1991

9 results

Effect of thymic hormone treatment on several immune functions of nude mice.

Ghanta VK, Hiramoto NS, Soong SJ, Hiramoto RN

Mechanisms of ageing and development1 May 1991Cited by 3 (Europe PMC)

PMID1875732 (opens in a new tab)DOI10.1016/0047-6374(91)90096-i (opens in a new tab)PepBankPUB-01875732
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In nude mice, FTS significantly increased peripheral blood lymphocyte numbers.

    In plain wordsIn nude mice, FTS increased blood lymphocyte numbers compared with saline controls.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreasePeripheral blood lymphocyte number
    Study

    mousen: not reported in source

    Balb/c nude mice
    Comparator
    Saline control
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    1 microgram and 10 ng · 3 weeksAs given in this study (mouse).

    Source sentences

    Summary
    Treatment with FTS significantly elevated the number of PBL.
    1 context sentence
    Summary · context
    Balb/c nude mice (about 12-16-week-old) were treated 5 times per week for 3 weeks with: Facteur Thymic Serique (FTS) and Thymopentin (TP5, Thymopoietin 32-36) at 1 microgram and 10 ng

Studies that did not test the peptide alone8

In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymulin (serum thymic factor).

  1. 02AnimalNot a test of Thymulin (serum thymic factor) aloneAnimal study (in vivo)Efficacy outcome

    In nude mice, weight was similar among hormone-treated groups including FTS and saline controls.

    In plain wordsIn nude mice, weight was similar among hormone-treated groups including FTS and saline controls.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    No significant changeBody weight
    Study

    mousen: not reported in source

    Balb/c nude mice
    Comparator
    Saline control
    Outcome group
    Body weight · Metabolic and weight

    Source sentences

    Summary
    The results show that weight and hematocrit were similar among the groups.

    In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).

  2. 03AnimalNot a test of Thymulin (serum thymic factor) aloneAnimal study (in vivo)Efficacy outcome

    In nude mice, hematocrit was similar among hormone-treated groups including FTS and saline controls.

    In plain wordsIn nude mice, hematocrit was similar among hormone-treated groups including FTS and saline controls.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    No significant changeHematocrit
    Study

    mousen: not reported in source

    Balb/c nude mice
    Comparator
    Saline control
    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    The results show that weight and hematocrit were similar among the groups.

    In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).

  3. 04AnimalNot a test of Thymulin (serum thymic factor) aloneAnimal study (in vivo)Efficacy outcome

    In nude mice, the spleen PHA response did not differ among treatment groups including FTS and saline controls.

    In plain wordsIn nude mice, spleen responses to PHA were similar among treatment groups including FTS and saline controls.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    No significant changeSpleen PHA response
    Study

    mousen: not reported in source

    Balb/c nude mice
    Comparator
    Saline control
    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    The phytohemagglutinin (PHA) response was not different among the treatment groups.

    In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).

  4. 05AnimalNot a test of Thymulin (serum thymic factor) aloneAnimal study (in vivo)Efficacy outcome

    In nude mice, pooled hormone treatments including FTS increased blood lymphocyte ConA responses nonsignificantly versus saline.

    In plain wordsIn nude mice, hormone treatments including FTS did not significantly increase blood lymphocyte responses to ConA compared with saline.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    No significant changePeripheral blood lymphocyte ConA response
    Study

    mousen: not reported in source

    Balb/c nude mice
    Comparator
    Saline control
    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    The PBL mitogen response to ConA and LPS was generally increased over saline control in the hormone treated groups but was not statistically significant.

    In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).

  5. 06AnimalNot a test of Thymulin (serum thymic factor) aloneAnimal study (in vivo)Efficacy outcome

    In nude mice, pooled hormone treatments including FTS increased blood lymphocyte LPS responses nonsignificantly versus saline.

    In plain wordsIn nude mice, hormone treatments including FTS did not significantly increase blood lymphocyte responses to LPS compared with saline.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    No significant changePeripheral blood lymphocyte LPS response
    Study

    mousen: not reported in source

    Balb/c nude mice
    Comparator
    Saline control
    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    The PBL mitogen response to ConA and LPS was generally increased over saline control in the hormone treated groups but was not statistically significant.

    In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).

  6. 07AnimalNot a test of Thymulin (serum thymic factor) aloneAnimal study (in vivo)Efficacy outcome

    In nude mice, the peripheral blood lymphocyte PHA response was only slightly elevated with pooled hormone treatments including FTS.

    In plain wordsIn nude mice, hormone treatments including FTS slightly increased blood lymphocyte responses to PHA compared with saline.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreasePeripheral blood lymphocyte PHA response
    Study

    mousen: not reported in source

    Balb/c nude mice
    Comparator
    Saline control
    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    The PHA response was only slightly elevated.
    1 context sentence
    Summary · context
    The PBL mitogen response to ConA and LPS was generally increased over saline control in the hormone treated groups but was not statistically significant.

    In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).

  7. 08AnimalNot a test of Thymulin (serum thymic factor) aloneAnimal study (in vivo)Efficacy outcome

    In nude mice, no cytotoxic T lymphocytes developed in any group, including FTS-treated mice and controls.

    In plain wordsIn nude mice, no group developed cytotoxic T lymphocytes, including FTS-treated mice and controls.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    No significant changeCytotoxic T-lymphocyte generation
    Study

    mousen: not reported in source

    Balb/c nude mice
    Comparator
    Saline control
    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    No CTL was generated in nude mice in any of the groups.

    In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).

  8. 09AnimalNot a test of Thymulin (serum thymic factor) aloneAnimal study (in vivo)Efficacy outcome

    In nude mice, all hormone treatments including FTS significantly depressed NK activity compared with saline.

    In plain wordsIn nude mice, all hormone treatments including FTS reduced natural killer cell activity compared with saline.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    DecreaseNK activity
    Study

    mousen: not reported in source

    Balb/c nude mice
    Comparator
    Saline control
    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    However, there was a statistically significant general depression of NK activity in all of the hormone treated animals compared with saline.

    In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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