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Study · Animal study (in vivo) · mouse · 1991

6 results

Survey of thymic hormone effects on physical and immunological parameters in C57BL/6NNia mice of different ages.

Ghanta VK, Hiramoto NS, Soong SJ, Hiramoto RN

Annals of the New York Academy of Sciences1 Jan 1991Cited by 8 (Europe PMC)

PMID1859089 (opens in a new tab)DOI10.1111/j.1749-6632.1991.tb16983.x (opens in a new tab)PepBankPUB-01859089
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice of different ages, FTS produced the greatest enhancing or suppressing changes among the hormones in the measured parameters.

    In plain wordsIn mice of different ages, FTS produced the largest increases or decreases in measured parameters among the hormones.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    MixedMagnitude and direction of measured parameter changes
    Study

    mousen: not reported in source

    Healthy C57BL/6NNia mice of different ages
    Comparator
    TP5, TM4, and TF5
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated · 3 wkAs given in this study (mouse).

    Source sentences

    Summary
    Treatment with FTS showed the greatest changes in either enhancing or suppressing the different parameters measured.
    2 context sentences
    Summary · context
    These studies compared FTS, TP5, TM4, and TF5 in C57BL/6NNia mice.
    Summary · context
    Mice aged 4, 26, 52, 78 and 104 wk were treated with various hormones 5x/wk for 3 wk

Studies that did not test the peptide alone5

In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymulin (serum thymic factor).

  1. 02AnimalNot a test of Thymulin (serum thymic factor) aloneAnimal study (in vivo)Efficacy outcome

    In mice of different ages, pooled thymic hormone treatments including FTS altered mitogen responses inconsistently across hormones.

    In plain wordsIn mice of different ages, thymic hormone treatments including FTS changed mitogen responses, with inconsistent effects across hormones.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    MixedMitogen responses
    Study

    mousen: not reported in source

    Healthy C57BL/6NNia mice of different ages
    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    Hormone treatments altered mitogen responses, enhanced IgM hemolysin autoantibody production, and modulated cell-mediated immune responses. The effects were not consistent for every hormone.
    2 context sentences
    Summary · context
    These studies compared FTS, TP5, TM4, and TF5 in C57BL/6NNia mice.
    Summary · context
    Mice aged 4, 26, 52, 78 and 104 wk were treated with various hormones 5x/wk for 3 wk

    In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).

  2. 03AnimalNot a test of Thymulin (serum thymic factor) aloneAnimal study (in vivo)Efficacy outcome

    In mice of different ages, pooled thymic hormone treatments including FTS enhanced IgM hemolysin autoantibody production inconsistently across hormones.

    In plain wordsIn mice of different ages, thymic hormone treatments including FTS increased IgM autoantibodies, with inconsistent effects across hormones.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseIgM hemolysin autoantibody production
    Study

    mousen: not reported in source

    Healthy C57BL/6NNia mice of different ages
    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    Hormone treatments altered mitogen responses, enhanced IgM hemolysin autoantibody production, and modulated cell-mediated immune responses. The effects were not consistent for every hormone.
    2 context sentences
    Summary · context
    These studies compared FTS, TP5, TM4, and TF5 in C57BL/6NNia mice.
    Summary · context
    Mice aged 4, 26, 52, 78 and 104 wk were treated with various hormones 5x/wk for 3 wk

    In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).

  3. 04AnimalNot a test of Thymulin (serum thymic factor) aloneAnimal study (in vivo)Efficacy outcome

    In mice of different ages, pooled thymic hormone treatments including FTS modulated cell-mediated immune responses inconsistently across hormones.

    In plain wordsIn mice of different ages, thymic hormone treatments including FTS changed cell-mediated immunity, with inconsistent effects across hormones.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    MixedCell-mediated immune responses
    Study

    mousen: not reported in source

    Healthy C57BL/6NNia mice of different ages
    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    Hormone treatments altered mitogen responses, enhanced IgM hemolysin autoantibody production, and modulated cell-mediated immune responses. The effects were not consistent for every hormone.
    2 context sentences
    Summary · context
    These studies compared FTS, TP5, TM4, and TF5 in C57BL/6NNia mice.
    Summary · context
    Mice aged 4, 26, 52, 78 and 104 wk were treated with various hormones 5x/wk for 3 wk

    In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).

  4. 05AnimalNot a test of Thymulin (serum thymic factor) aloneAnimal study (in vivo)Efficacy outcome

    In old mice, pooled hormone treatment including FTS did not restore immune parameters to young-animal levels.

    In plain wordsIn old mice, hormone treatments including FTS did not restore immune measures to young-mouse levels.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    No significant changeRestoration of old-mouse immune parameters
    Study

    mousen: not reported in source

    Healthy C57BL/6NNia mice of different ages
    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    Hormone treatment did not restore any immune parameters in old mice to the level of young animals.
    2 context sentences
    Summary · context
    These studies compared FTS, TP5, TM4, and TF5 in C57BL/6NNia mice.
    Summary · context
    Mice aged 4, 26, 52, 78 and 104 wk were treated with various hormones 5x/wk for 3 wk

    In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).

  5. 06AnimalNot a test of Thymulin (serum thymic factor) aloneAnimal study (in vivo)Efficacy outcome

    In mice, pooled thymic hormone responses tended toward enhancement in younger animals and suppression in older animals.

    In plain wordsIn mice, hormone treatments including FTS tended to enhance responses in younger animals and suppress responses in older animals.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    MixedAge dependence of hormone responses
    Study

    mousen: not reported in source

    Healthy C57BL/6NNia mice of different ages
    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    There was a tendency for enhancement in younger mice and suppression in older animals.
    3 context sentences
    Summary · context
    The hormonal effects appeared to be age specific in that certain activities were altered for certain age groups but not in others.
    Summary · context
    These studies compared FTS, TP5, TM4, and TF5 in C57BL/6NNia mice.
    Summary · context
    Mice aged 4, 26, 52, 78 and 104 wk were treated with various hormones 5x/wk for 3 wk

    In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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