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Study · Animal study (in vivo) · cynomolgus macaque · 1991

3 results

Growth hormone (GH) responses to the hexapeptide GH-releasing peptide and GH-releasing hormone (GHRH) in the cynomolgus macaque: evidence for non-GHRH-mediated responses.

Malozowski S, Hao EH, Ren SG, Marin G, Liu L, Southers JL, Merriam GR

The Journal of clinical endocrinology and metabolism1 Aug 1991Cited by 28 (Europe PMC)

PMID1856262 (opens in a new tab)DOI10.1210/jcem-73-2-314 (opens in a new tab)PepBankPUB-01856262
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Activity measurement

    In cynomolgus macaques, GHRP had lower GH-releasing potency than GHRH.

    In plain wordsIn macaques, GHRP had lower GH-releasing potency than GHRH.

    Peptide
    GHRP-6
    Outcome
    DecreaseRelative potency
    Study

    cynomolgus macaquen = 6

    unanesthetized young adult macaques
    Comparator
    GHRH
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    0.03-3 mg/kg · intravenousAs given in this study (cynomolgus macaque).

    Source sentences

    Summary
    GHRP had lower potency, but evoked a much higher peak GH response than GHRH (greater than 55 vs. 12 micrograms/L).
    2 context sentences
    Summary · context
    Doses ranged from 0.03-3 mg/kg for GHRP and from 1-30 micrograms/kg for GHRH.
    Summary · context
    To characterize the GHRP dose-response curve and compare it with that of GH-releasing hormone [GHRH-(1-44)NH2], six unanesthetized young adult cynomolgus macaques were tested with a range of iv doses of GHRP or GHRH in random order.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In cynomolgus macaques, GHRP evoked a higher peak GH response than GHRH.

    In plain wordsIn macaques, GHRP produced a higher peak GH response than GHRH.

    Peptide
    GHRP-6
    Outcome
    IncreasePeak GH response
    Study

    cynomolgus macaquen = 6

    unanesthetized young adult macaques
    Comparator
    GHRH
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones
    Studied dose
    0.03-3 mg/kg · intravenousAs given in this study (cynomolgus macaque).

    Measurements

    Peak GH
    > 55 micrograms/L
    GHRP
    Peak GH
    12 micrograms/L
    GHRH

    Source sentences

    Summary
    GHRP had lower potency, but evoked a much higher peak GH response than GHRH (greater than 55 vs. 12 micrograms/L).
    2 context sentences
    Summary · context
    Doses ranged from 0.03-3 mg/kg for GHRP and from 1-30 micrograms/kg for GHRH.
    Summary · context
    To characterize the GHRP dose-response curve and compare it with that of GH-releasing hormone [GHRH-(1-44)NH2], six unanesthetized young adult cynomolgus macaques were tested with a range of iv doses of GHRP or GHRH in random order.

Studies that did not test the peptide alone1

In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-6.

  1. 03AnimalNot a test of GHRP-6 aloneAnimal study (in vivo)Mechanism

    In cynomolgus macaques, propranolol pretreatment doubled the GH response to GHRP compared with GHRP alone.

    In plain wordsIn macaques, propranolol before GHRP increased the GH response compared with GHRP alone.

    Peptide
    GHRP-6
    Outcome
    IncreasePropranolol potentiation
    Study

    cynomolgus macaquen: not reported in source

    unanesthetized young adult macaques
    Comparator
    GHRP alone
    Outcome group
    Growth hormone and IGF-1 · Endocrine and hormones

    Measurements

    Peak GH
    54 micrograms/L
    propranolol plus GHRP
    Peak GH
    25 micrograms/L
    GHRP alone

    Source sentences

    Summary
    However, propranolol pretreatment doubled the GH responses to both GHRH and GHRP compared with those to GHRH or GHRP alone 28 +/- 5 micrograms/L vs. 14 +/- 5 (P less than 0.05) and 54 +/- 2 vs. 25 +/- 6 micrograms/L (P less than 0.001), respectively].
    2 context sentences
    Summary · context
    Propranolol was given at a dose of 14 micrograms/kg, iv, 10 min before the injection of saline, GHRH (10 micrograms/kg), or GHRP (1 mg/kg).
    Summary · context
    To characterize the GHRP dose-response curve and compare it with that of GH-releasing hormone [GHRH-(1-44)NH2], six unanesthetized young adult cynomolgus macaques were tested with a range of iv doses of GHRP or GHRH in random order.

    In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:59 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:13 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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