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Study · Not a test of the peptide alone · 1991

2 results

N-terminal degradation of ACTH(4-10) and its synthetic analog semax by the rat blood enzymes.

Potaman VN, Alfeeva LY, Kamensky AA, Levitzkaya NG, Nezavibatko VN

Biochemical and biophysical research communications1 Apr 1991Cited by 11 (Europe PMC)

PMID1851003 (opens in a new tab)DOI10.1016/s0006-291x(05)80247-5 (opens in a new tab)PepBankPUB-01851003
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone2

In this study, Semax was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Semax.

  1. 01LabNot a test of Semax aloneEx vivo tissueOther

    In rat serum, about one third to one half of the degrading activity came from a bestatin-sensitive aminopeptidase that cleaved the first and second N-terminal residues.

    In plain wordsIn lab tests with rat serum, an aminopeptidase caused about one third to one half of the activity that breaks down the peptides.

    Peptide
    Semax
    Outcome
    Not applicableShare of serum degrading activity from bestatin-sensitive aminopeptidase
    Study

    ratn: not reported in source

    Rat blood and serum
    Outcome group
    Pharmacokinetics · Pharmacology

    Source sentences

    Summary
    About one third to one half of the serum degrading activity could be ascribed to bestatin-sensitive aminopeptidase which cleaved first and second N-terminal residues Met and Glu producing relatively stable intermediates.
    1 context sentence
    Summary · context
    Degradation of a regulatory peptide ACTH(4-10) and its synthetic analog semax in rat blood and serum was studied using high-performance liquid chromatography.

    In this study, Semax was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Semax.

  2. 02LabNot a test of Semax aloneEx vivo tissueOther

    In rat blood and serum, semax was more stable than ACTH(4-10) against the action of other degrading enzymes.

    In plain wordsIn lab tests with rat blood and serum, semax resisted breakdown by some enzymes better than ACTH(4-10).

    Peptide
    Semax
    Outcome
    IncreaseStability against degrading enzymes versus ACTH(4-10)
    Study

    ratn: not reported in source

    Rat blood and serum
    Comparator
    ACTH(4-10)
    Outcome group
    Pharmacokinetics · Pharmacology

    Source sentences

    Summary
    Semax turned out to be more stable than ACTH(4-10) against the action of other enzymes that took part in degradation.
    1 context sentence
    Summary · context
    Degradation of a regulatory peptide ACTH(4-10) and its synthetic analog semax in rat blood and serum was studied using high-performance liquid chromatography.

    In this study, Semax was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Semax.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 19:08 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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