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Study · Randomized controlled trial · n = 2 · 1991

5 results

Medical treatment of endometriosis: a comparison of the suppressive effects of danazol and nafarelin on reproductive hormones.

Hickok LR, Burry KA, Cohen NL, Moore DE, Dahl KD, Soules MR

Fertility and sterility1 Oct 1991Cited by 10 (Europe PMC)

PMID1833245 (opens in a new tab)DOI10.1016/s0015-0282(16)54590-7 (opens in a new tab)PepBankPUB-01833245
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. 5 results from people.

  1. 01HumanRandomized controlled trialMechanism

    In patients with endometriosis, nafarelin suppressed estradiol significantly more than danazol (P less than or equal to 0.01).

    In plain wordsIn patients with endometriosis, nafarelin suppressed estradiol significantly more than danazol.

    Peptide
    Nafarelin
    Outcome
    DecreaseEstradiol suppression versus danazol
    Study

    n: not reported in source

    Comparator
    Danazol 800 mg/d
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    800 or 400 micrograms/d · 6 monthsAs given in this study (human).

    Source sentences

    Summary
    Estradiol and P were suppressed in all groups, but E2 significantly more by nafarelin than danazol (P less than or equal to 0.01).
    3 context sentences
    Summary · context
    The study included 16 patients who were randomized into one of three 6-month treatment protocols.
    Summary · context
    Eligible candidates were 18 to 45 years of age, with regular menses and documented pelvic endometriosis.
    Summary · context
    Six-month treatment protocols included nafarelin 800 or 400 micrograms/d, or danazol 800 mg/d.
  2. 02HumanRandomized controlled trialMechanism

    In patients with endometriosis, nafarelin 800 micrograms significantly depressed LH pulse amplitude versus danazol (P less than or equal to 0.05).

    In plain wordsIn patients with endometriosis, nafarelin reduced LH pulse amplitude more than danazol.

    Peptide
    Nafarelin
    Outcome
    DecreaseLH pulse amplitude
    Study

    n: not reported in source

    Comparator
    Danazol 800 mg/d
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    800 micrograms/d · 6 monthsAs given in this study (human).

    Source sentences

    Summary
    Nafarelin, 800 micrograms, significantly depressed LH pulse amplitude compared with danazol (P less than or equal to 0.05).
    3 context sentences
    Summary · context
    The study included 16 patients who were randomized into one of three 6-month treatment protocols.
    Summary · context
    Eligible candidates were 18 to 45 years of age, with regular menses and documented pelvic endometriosis.
    Summary · context
    Six-month treatment protocols included nafarelin 800 or 400 micrograms/d, or danazol 800 mg/d.
  3. 03HumanNon-randomized trialMechanism

    Two patients with endometriosis demonstrated single high-amplitude pulses immediately after observed nafarelin administration.

    In plain wordsTwo patients with endometriosis showed single high-amplitude hormone pulses immediately after observed nafarelin administration.

    Peptide
    Nafarelin
    Outcome
    Not applicableImmediate high-amplitude pulses
    Study

    n = 2

    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    800 or 400 micrograms/dAs given in this study (human).

    Source sentences

    Summary
    Two patients in the nafarelin group had the administration of their medication observed, and both demonstrated single, high-amplitude pulses immediately after administration.
    3 context sentences
    Summary · context
    The study included 16 patients who were randomized into one of three 6-month treatment protocols.
    Summary · context
    Eligible candidates were 18 to 45 years of age, with regular menses and documented pelvic endometriosis.
    Summary · context
    Six-month treatment protocols included nafarelin 800 or 400 micrograms/d, or danazol 800 mg/d.
  4. 04HumanNon-randomized trialMechanism

    In patients with endometriosis, estradiol was suppressed during nafarelin treatment, as it was with danazol.

    In plain wordsIn patients with endometriosis, estradiol was suppressed during nafarelin treatment, as it was with danazol.

    Peptide
    Nafarelin
    Outcome
    DecreaseEstradiol suppression versus baseline
    Study

    n: not reported in source

    Comparator
    Pretreatment
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    800 or 400 micrograms/d · 6 monthsAs given in this study (human).

    Source sentences

    Summary
    Estradiol and P were suppressed in all groups, but E2 significantly more by nafarelin than danazol (P less than or equal to 0.01).
    3 context sentences
    Summary · context
    The study included 16 patients who were randomized into one of three 6-month treatment protocols.
    Summary · context
    Eligible candidates were 18 to 45 years of age, with regular menses and documented pelvic endometriosis.
    Summary · context
    Six-month treatment protocols included nafarelin 800 or 400 micrograms/d, or danazol 800 mg/d.
  5. 05HumanNon-randomized trialMechanism

    In patients with endometriosis, progesterone was suppressed during nafarelin treatment, as it was with danazol.

    In plain wordsIn patients with endometriosis, progesterone was suppressed during nafarelin treatment, as it was with danazol.

    Peptide
    Nafarelin
    Outcome
    DecreaseProgesterone suppression versus baseline
    Study

    n: not reported in source

    Comparator
    Pretreatment
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    800 or 400 micrograms/d · 6 monthsAs given in this study (human).

    Source sentences

    Summary
    Estradiol and P were suppressed in all groups, but E2 significantly more by nafarelin than danazol (P less than or equal to 0.01).
    3 context sentences
    Summary · context
    The study included 16 patients who were randomized into one of three 6-month treatment protocols.
    Summary · context
    Eligible candidates were 18 to 45 years of age, with regular menses and documented pelvic endometriosis.
    Summary · context
    Six-month treatment protocols included nafarelin 800 or 400 micrograms/d, or danazol 800 mg/d.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:36 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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