A peptidase-resistant cyclic octapeptide analogue of somatostatin (SMS 201-995) modulates seizures induced by quinolinic and kainic acids differently in the rat hippocampus.

Vezzani A, Serafini R, Stasi MA, Viganò G, Rizzi M, Samanin R

Neuropharmacology1 Apr 1991Cited by 57 (Europe PMC)

PMID1830135DOI10.1016/0028-3908(91)90059-kPepBankPUB-01830135

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

10 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats, octreotide given 15 min before quinolinic acid did not significantly change seizure number.
In plain wordsIn rats, octreotide did not significantly change quinolinic acid-induced seizure number compared with the challenge without octreotide.
Peptide
Octreotide
Outcome
No significant changeQuinolinic acid seizure count
Study
ratn: not reported in source
Hippocampal chemically induced seizures
Comparator
Corresponding seizure challenge without octreotide
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
5 micrograms · injection into stratum radiatumAs given in this study (rat).
Source sentences
Summary
Injection of 5 micrograms SMS 201-995, a peptidase-resistant cyclic octapeptide analogue of somatostatin, into the stratum radiatum, 15 min before quinolinic acid, did not significantly modify the number of seizures and the total time in seizures.
1 context sentence(design, population, supporting numbers)
Summary · context
Electroencephalographic (EEG) seizures were measured in rats after intrahippocampal injection of 120 nmol quinolinic acid into the stratum radiatum CA1 or 0.19 nmol kainic acid in the dentate gyrus or in the stratum radiatum.
Report a problemFND-0183013501
02AnimalAnimal study (in vivo)Efficacy outcome
In rats, octreotide given 15 min before quinolinic acid did not significantly change total seizure time.
In plain wordsIn rats, octreotide did not significantly change quinolinic acid-induced seizure time compared with the challenge without octreotide.
Peptide
Octreotide
Outcome
No significant changeQuinolinic acid total seizure time
Study
ratn: not reported in source
Hippocampal chemically induced seizures
Comparator
Corresponding seizure challenge without octreotide
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
5 micrograms · injection into stratum radiatumAs given in this study (rat).
Source sentences
Summary
Injection of 5 micrograms SMS 201-995, a peptidase-resistant cyclic octapeptide analogue of somatostatin, into the stratum radiatum, 15 min before quinolinic acid, did not significantly modify the number of seizures and the total time in seizures.
1 context sentence(design, population, supporting numbers)
Summary · context
Electroencephalographic (EEG) seizures were measured in rats after intrahippocampal injection of 120 nmol quinolinic acid into the stratum radiatum CA1 or 0.19 nmol kainic acid in the dentate gyrus or in the stratum radiatum.
Report a problemFND-0183013502
03AnimalAnimal study (in vivo)Efficacy outcome
In rats, octreotide reduced kainic acid-induced seizure number by 58% (Student's t-test; P less than 0.01).
In plain wordsIn rats, octreotide reduced kainic acid-induced seizure number by 58% compared with the challenge without octreotide.
Peptide
Octreotide
Outcome
DecreaseKainic acid seizure count
Study
ratn: not reported in source
Hippocampal chemically induced seizures
Comparator
Corresponding seizure challenge without octreotide
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
5 micrograms · injection into stratum radiatumAs given in this study (rat).
Source sentences
Summary
Five micrograms SMS 201-995 injected into the stratum radiatum reduced the number of seizures induced by kainic acid in the same area and the total time spent in seizures by 58% and 75%, respectively (Student's t-test; P less than 0.01).
1 context sentence(design, population, supporting numbers)
Summary · context
Electroencephalographic (EEG) seizures were measured in rats after intrahippocampal injection of 120 nmol quinolinic acid into the stratum radiatum CA1 or 0.19 nmol kainic acid in the dentate gyrus or in the stratum radiatum.
Report a problemFND-0183013503
04AnimalAnimal study (in vivo)Efficacy outcome
In rats, octreotide reduced total time in kainic acid-induced seizures by 75% (Student's t-test; P less than 0.01).
In plain wordsIn rats, octreotide reduced kainic acid-induced seizure time by 75% compared with the challenge without octreotide.
Peptide
Octreotide
Outcome
DecreaseKainic acid total seizure time
Study
ratn: not reported in source
Hippocampal chemically induced seizures
Comparator
Corresponding seizure challenge without octreotide
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
5 micrograms · injection into stratum radiatumAs given in this study (rat).
Source sentences
Summary
Five micrograms SMS 201-995 injected into the stratum radiatum reduced the number of seizures induced by kainic acid in the same area and the total time spent in seizures by 58% and 75%, respectively (Student's t-test; P less than 0.01).
1 context sentence(design, population, supporting numbers)
Summary · context
Electroencephalographic (EEG) seizures were measured in rats after intrahippocampal injection of 120 nmol quinolinic acid into the stratum radiatum CA1 or 0.19 nmol kainic acid in the dentate gyrus or in the stratum radiatum.
Report a problemFND-0183013504
05AnimalAnimal study (in vivo)Efficacy outcome
In rats, octreotide did not significantly modify latency to the first quinolinic acid-induced ictal episode.
In plain wordsIn rats, octreotide did not significantly change quinolinic acid seizure latency compared with the challenge without octreotide.
Peptide
Octreotide
Outcome
No significant changeQuinolinic acid seizure latency
Study
ratn: not reported in source
Hippocampal chemically induced seizures
Comparator
Corresponding seizure challenge without octreotide
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
5 micrograms · injection into stratum radiatumAs given in this study (rat).
Source sentences
Summary
In both instances the latency to the first ictal episode was not significantly modified.
2 context sentences(design, population, supporting numbers)
Summary · context
Injection of 5 micrograms SMS 201-995, a peptidase-resistant cyclic octapeptide analogue of somatostatin, into the stratum radiatum, 15 min before quinolinic acid, did not significantly modify the number of seizures and the total time in seizures.
Summary · context
Electroencephalographic (EEG) seizures were measured in rats after intrahippocampal injection of 120 nmol quinolinic acid into the stratum radiatum CA1 or 0.19 nmol kainic acid in the dentate gyrus or in the stratum radiatum.
Report a problemFND-0183013505
06AnimalAnimal study (in vivo)Efficacy outcome
In rats, octreotide did not significantly modify latency to the first kainic acid-induced ictal episode.
In plain wordsIn rats, octreotide did not significantly change kainic acid seizure latency compared with the challenge without octreotide.
Peptide
Octreotide
Outcome
No significant changeKainic acid seizure latency
Study
ratn: not reported in source
Hippocampal chemically induced seizures
Comparator
Corresponding seizure challenge without octreotide
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
5 micrograms · injection into stratum radiatumAs given in this study (rat).
Source sentences
Summary
In both instances the latency to the first ictal episode was not significantly modified.
2 context sentences(design, population, supporting numbers)
Summary · context
Five micrograms SMS 201-995 injected into the stratum radiatum reduced the number of seizures induced by kainic acid in the same area and the total time spent in seizures by 58% and 75%, respectively (Student's t-test; P less than 0.01).
Summary · context
Electroencephalographic (EEG) seizures were measured in rats after intrahippocampal injection of 120 nmol quinolinic acid into the stratum radiatum CA1 or 0.19 nmol kainic acid in the dentate gyrus or in the stratum radiatum.
Report a problemFND-0183013506
07AnimalAnimal study (in vivo)Efficacy outcome
In rats with medial septum lesions, octreotide reduced total seizure time by 43%.
In plain wordsIn rats with septal lesions, octreotide reduced quinolinic acid seizure time by 43% compared with the challenge without octreotide.
Peptide
Octreotide
Outcome
DecreaseSeizure time after septal lesions
Study
ratn: not reported in source
Medial septum-lesioned rats challenged with quinolinic acid
Comparator
Corresponding seizure challenge without octreotide
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
5 micrograms · injection into stratum radiatumAs given in this study (rat).
Source sentences
Summary
In rats lesioned in the medial septum, 5 micrograms SMS 201-995 reduced the total time spent in seizures by 43%
1 context sentence(design, population, supporting numbers)
Summary · context
Electroencephalographic (EEG) seizures were measured in rats after intrahippocampal injection of 120 nmol quinolinic acid into the stratum radiatum CA1 or 0.19 nmol kainic acid in the dentate gyrus or in the stratum radiatum.
Report a problemFND-0183013507
08AnimalAnimal study (in vivo)Efficacy outcome
In rats with medial septum lesions, octreotide did not change the number of ictal episodes.
In plain wordsIn rats with septal lesions, octreotide did not change quinolinic acid seizure number compared with the challenge without octreotide.
Peptide
Octreotide
Outcome
No significant changeSeizure count after septal lesions
Study
ratn: not reported in source
Medial septum-lesioned rats challenged with quinolinic acid
Comparator
Corresponding seizure challenge without octreotide
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
5 micrograms · injection into stratum radiatumAs given in this study (rat).
Source sentences
Summary
In rats lesioned in the medial septum, 5 micrograms SMS 201-995 reduced the total time spent in seizures by 43%, without changing the number of ictal episodes
1 context sentence(design, population, supporting numbers)
Summary · context
Electroencephalographic (EEG) seizures were measured in rats after intrahippocampal injection of 120 nmol quinolinic acid into the stratum radiatum CA1 or 0.19 nmol kainic acid in the dentate gyrus or in the stratum radiatum.
Report a problemFND-0183013508
09AnimalAnimal study (in vivo)Efficacy outcome
In rats with medial septum lesions, octreotide raised latency to the first quinolinic acid-induced seizure by 53% (ANOVA 2 x 2, P less than 0.05).
In plain wordsIn rats with septal lesions, octreotide increased quinolinic acid seizure latency by 53% compared with the challenge without octreotide.
Peptide
Octreotide
Outcome
IncreaseSeizure latency after septal lesions
Study
ratn: not reported in source
Medial septum-lesioned rats challenged with quinolinic acid
Comparator
Corresponding seizure challenge without octreotide
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
5 micrograms · injection into stratum radiatumAs given in this study (rat).
Source sentences
Summary
and raised the latency to the first quinolinic acid-induced seizure by 53% (ANOVA 2 x 2, P less than 0.05)
1 context sentence(design, population, supporting numbers)
Summary · context
Electroencephalographic (EEG) seizures were measured in rats after intrahippocampal injection of 120 nmol quinolinic acid into the stratum radiatum CA1 or 0.19 nmol kainic acid in the dentate gyrus or in the stratum radiatum.
Report a problemFND-0183013509
10AnimalAnimal study (in vivo)Efficacy outcome
In sham-operated rats, octreotide did not affect total seizure time, ictal episode number or latency to the first quinolinic acid-induced seizure.
In plain wordsIn sham-operated rats, octreotide did not change the reported quinolinic acid seizure measures compared with the challenge without octreotide.
Peptide
Octreotide
Outcome
No significant changeSeizure measures in sham-operated rats
Study
ratn: not reported in source
Sham-operated rats challenged with quinolinic acid
Comparator
Corresponding seizure challenge without octreotide
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
5 micrograms · injection into stratum radiatumAs given in this study (rat).
Source sentences
Summary
but had no effect on these measures in the corresponding sham-operated group.(ABSTRACT TRUNCATED AT 250 WORDS)
1 context sentence(design, population, supporting numbers)
Summary · context
Electroencephalographic (EEG) seizures were measured in rats after intrahippocampal injection of 120 nmol quinolinic acid into the stratum radiatum CA1 or 0.19 nmol kainic acid in the dentate gyrus or in the stratum radiatum.
Report a problemFND-0183013510

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
28 Oct 2026, 02:03 UTC
Study results updated
Version 1
27 Oct 2026, 16:36 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

PepBank is a research reference. Talk to a doctor before you use any peptide.