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Study · Non-randomized trial · n = 56 · 1991

3 results

Analgesic effect of salmon calcitonin in osteoporotic vertebral fractures: a double-blind placebo-controlled clinical study.

Lyritis GP, Tsakalakos N, Magiasis B, Karachalios T, Yiatzides A, Tsekoura M

Calcified tissue international1 Dec 1991Cited by 85 (Europe PMC)

PMID1818759 (opens in a new tab)DOI10.1007/bf02555844 (opens in a new tab)PepBankPUB-01818759
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In patients with recent osteoporotic vertebral fracture, salmon calcitonin reduced pain versus placebo (P less than 0.001), generally from the second day.

    In plain wordsIn patients with recent osteoporotic vertebral fracture, salmon calcitonin reduced pain compared with placebo.

    Peptide
    Calcitonin-salmon
    Outcome
    DecreasePain intensity
    Study

    n = 56

    Comparator
    Placebo
    Outcome group
    Pain · Musculoskeletal
    Studied dose
    100 IU daily · injection · 14 daysAs given in this study (human).

    Source sentences

    Summary
    The results showed a significant (P less than 0.001) difference in pain intensity between the calcitonin group and the placebo group.
    2 context sentences
    Summary · context
    This beneficial effect was generally apparent from the second day of treatment onward, and over the following 2 weeks, the patients were able to sit and stand, and gradually started to walk again.
    Summary · context
    In this double-blind controlled clinical trial, 56 patients who had recently (within the last 3 days) suffered an osteoporotic vertebral fracture were hospitalized for a period of 14 days. Salmon calcitonin (100 IU) or placebo injections were given daily.
  2. 02HumanNon-randomized trialEfficacy outcome

    In patients with recent osteoporotic vertebral fracture, salmon calcitonin significantly reduced urinary hydroxyproline.

    In plain wordsIn patients with recent osteoporotic vertebral fracture, salmon calcitonin reduced urinary hydroxyproline.

    Peptide
    Calcitonin-salmon
    Outcome
    DecreaseUrinary hydroxyproline
    Study

    n: not reported in source

    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    100 IU daily · injection · 14 daysAs given in this study (human).

    Source sentences

    Summary
    A significant decrease in urinary hydroxyproline and urinary calcium was also noted in the calcitonin group.
    1 context sentence
    Summary · context
    In this double-blind controlled clinical trial, 56 patients who had recently (within the last 3 days) suffered an osteoporotic vertebral fracture were hospitalized for a period of 14 days. Salmon calcitonin (100 IU) or placebo injections were given daily.
  3. 03HumanNon-randomized trialEfficacy outcome

    In patients with recent osteoporotic vertebral fracture, salmon calcitonin significantly reduced urinary calcium.

    In plain wordsIn patients with recent osteoporotic vertebral fracture, salmon calcitonin reduced urinary calcium.

    Peptide
    Calcitonin-salmon
    Outcome
    DecreaseUrinary calcium
    Study

    n: not reported in source

    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    100 IU daily · injection · 14 daysAs given in this study (human).

    Source sentences

    Summary
    A significant decrease in urinary hydroxyproline and urinary calcium was also noted in the calcitonin group.
    1 context sentence
    Summary · context
    In this double-blind controlled clinical trial, 56 patients who had recently (within the last 3 days) suffered an osteoporotic vertebral fracture were hospitalized for a period of 14 days. Salmon calcitonin (100 IU) or placebo injections were given daily.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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