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Study · Randomized controlled trial · n = 12 · 1991

3 results

Vasopressin and oxytocin do not influence early sensory processing but affect mood and activation in man.

Pietrowsky R, Braun D, Fehm HL, Pauschinger P, Born J

Peptides1 Nov 1991Cited by 15 (Europe PMC)

PMID1815225 (opens in a new tab)DOI10.1016/0196-9781(91)90224-d (opens in a new tab)PepBankPUB-01815225
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In 12 healthy men, intravenous oxytocin and vasopressin had no consistent effect on brainstem auditory-evoked potentials.

    In plain wordsIn healthy men, oxytocin given into a vein did not consistently change the early brainstem response to sound.

    Peptide
    Oxytocin
    Outcome
    No significant changeBrainstem auditory-evoked potentials (BAEP)
    Study

    n = 12

    Comparator
    Placebo
    Outcome group
    Sensory perception · Nervous system and cognition
    Studied dose
    0.5 IU · intravenous bolusAs given in this study (human).

    Source sentences

    Summary
    There were no consistent effects of AVP and OX on BAEPs and MAEPs.
    1 context sentence
    Summary · context
    The experiments were undertaken in 12 healthy male volunteers, receiving either placebo, 0.15 IU AVP, 0.5 IU AVP or 0.5 IU OX as IV bolus injection according to a within-subject double-blind design.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In 12 healthy men, intravenous oxytocin and vasopressin had no consistent effect on middle latency auditory-evoked potentials.

    In plain wordsIn healthy men, oxytocin given into a vein did not consistently change the early cortex response to sound.

    Peptide
    Oxytocin
    Outcome
    No significant changeMiddle latency auditory-evoked potentials (MAEP)
    Study

    n = 12

    Comparator
    Placebo
    Outcome group
    Sensory perception · Nervous system and cognition
    Studied dose
    0.5 IU · intravenous bolusAs given in this study (human).

    Source sentences

    Summary
    There were no consistent effects of AVP and OX on BAEPs and MAEPs.
    1 context sentence
    Summary · context
    The experiments were undertaken in 12 healthy male volunteers, receiving either placebo, 0.15 IU AVP, 0.5 IU AVP or 0.5 IU OX as IV bolus injection according to a within-subject double-blind design.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In 12 healthy men, intravenous oxytocin and vasopressin were followed by changes towards increased self-perceived general activation.

    In plain wordsIn healthy men, oxytocin and vasopressin were followed by a higher self-rated feeling of activation.

    Peptide
    Oxytocin
    Outcome
    IncreaseSelf-perceived general activation
    Study

    n = 12

    Comparator
    Placebo
    Outcome group
    Anxiety and mood · Mental health and mood
    Studied dose
    0.5 IU · intravenous bolusAs given in this study (human).

    Source sentences

    Summary
    demonstrate changes towards increased (self-perceived) general activation following administration of these hormones.
    1 context sentence
    Summary · context
    Additionally, subjects rated their feelings of activation and mood on an adjective check list (EWL).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:52 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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