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Study · Measured the body's own peptide · 1991

6 results

Immunoreactive delta sleep-inducing peptide in the rat hypothalamus, pituitary and adrenal gland: effects of adrenalectomy.

Bjartell A, Sundler F, Ekman R

Hormone research1 Jan 1991Cited by 2 (Europe PMC)

PMID1814802 (opens in a new tab)DOI10.1159/000182108 (opens in a new tab)PepBankPUB-01814802
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

No result from this study comes from a test of the peptide.

Natural levels measured6

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In rats, the body's own DSIP immunoreactivity was colocalized with thyroid-stimulating hormone in the pituitary and with noradrenaline in the adrenal medulla.

    In plain wordsIn rats, the body's own DSIP was found together with thyroid-stimulating hormone in the pituitary and with noradrenaline in the adrenal gland.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Not applicableIR-DSIP colocalization in pituitary and adrenal gland
    Study

    ratn: not reported in source

    Adrenalectomized rats; pituitary, adrenal, hypothalamus and plasma
    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Source sentences

    Summary
    Immunoreactive (IR) delta sleep-inducing peptide (DSIP) was examined by immunocytochemistry in the rat pituitary and adrenal gland and found to be colocalized with IR thyroid-stimulating hormone in the pituitary and with noradrenaline in the adrenal medulla.

    This result measures the body's own Delta sleep-inducing peptide (DSIP). Nobody was given the peptide. It is not evidence about taking it.

  2. 02AnimalEndogenous levelAnimal study (in vivo)Other

    In rats, plasma levels of the body's own DSIP were significantly higher 5 days after bilateral adrenalectomy.

    In plain wordsIn rats, the body's own DSIP in blood rose 5 days after both adrenal glands were removed.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreasePlasma IR-DSIP after bilateral adrenalectomy
    Study

    ratn: not reported in source

    Adrenalectomized rats; pituitary, adrenal, hypothalamus and plasma
    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Source sentences

    Summary
    Significantly elevated plasma levels of IR-DSIP were measured 5 days after bilateral adrenalectomy (p less than 0.001).
    1 context sentence
    Summary · context
    By radioimmunoassay, IR-DSIP was quantified in plasma and tissue extracts after uni- or bilateral adrenalectomy.

    This result measures the body's own Delta sleep-inducing peptide (DSIP). Nobody was given the peptide. It is not evidence about taking it.

  3. 03AnimalEndogenous levelAnimal study (in vivo)Other

    In rats, pituitary levels of the body's own DSIP rose 5 days after bilateral adrenalectomy but not after 14 or 28 days.

    In plain wordsIn rats, the body's own DSIP in the pituitary rose 5 days after adrenal removal, but not after 14 or 28 days.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    MixedPituitary IR-DSIP after bilateral adrenalectomy
    Study

    ratn: not reported in source

    Adrenalectomized rats; pituitary, adrenal, hypothalamus and plasma
    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Source sentences

    Summary
    IR-DSIP was increased (p less than 0.05) in pituitary extracts from bilaterally adrenalectomized rats after 5 days, but not after 14 or 28 days.
    1 context sentence
    Summary · context
    By radioimmunoassay, IR-DSIP was quantified in plasma and tissue extracts after uni- or bilateral adrenalectomy.

    This result measures the body's own Delta sleep-inducing peptide (DSIP). Nobody was given the peptide. It is not evidence about taking it.

  4. 04AnimalEndogenous levelAnimal study (in vivo)Other

    In rats, plasma and tissue concentrations of the body's own DSIP did not differ between sham-operated and unoperated animals.

    In plain wordsIn rats, the body's own DSIP levels did not differ between sham-operated and unoperated animals.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeIR-DSIP in sham-operated and unoperated rats
    Study

    ratn: not reported in source

    Adrenalectomized rats; pituitary, adrenal, hypothalamus and plasma
    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Source sentences

    Summary
    Sham- and unoperated animals did not significantly differ in plasma or tissue concentration of IR-DSIP.
    1 context sentence
    Summary · context
    By radioimmunoassay, IR-DSIP was quantified in plasma and tissue extracts after uni- or bilateral adrenalectomy.

    This result measures the body's own Delta sleep-inducing peptide (DSIP). Nobody was given the peptide. It is not evidence about taking it.

  5. 05AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In rat hypothalamus extracts, HPLC showed a single peak of DSIP immunoreactive material of lower hydrophobicity than synthetic DSIP.

    In plain wordsIn rats, hypothalamus extracts held one form of the body's own DSIP-like material that was less water-repelling than synthetic DSIP.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Not applicableHPLC profile of hypothalamic IR-DSIP
    Study

    ratn: not reported in source

    Adrenalectomized rats; pituitary, adrenal, hypothalamus and plasma
    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Source sentences

    Summary
    High-performance liquid chromatography of C18 SEP-PAK purified hypothalamus extracts revealed a single peak of IR-DSIP material of lower hydrophobicity than synthetic DSIP.
    1 context sentence
    Summary · context
    By radioimmunoassay, IR-DSIP was quantified in plasma and tissue extracts after uni- or bilateral adrenalectomy.

    This result measures the body's own Delta sleep-inducing peptide (DSIP). Nobody was given the peptide. It is not evidence about taking it.

  6. 06AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In the rat posterior pituitary, DSIP immunoreactivity was detectable in nerve fibres.

    In plain wordsIn rats, the body's own DSIP was found in nerve fibres of the back part of the pituitary gland.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    Not applicableIR-DSIP in nerve fibres of the posterior pituitary
    Study

    ratn: not reported in source

    Rat pituitary, immunocytochemistry
    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Source sentences

    Summary
    IR-DSIP was also detectable in nerve fibers in the posterior pituitary.

    This result measures the body's own Delta sleep-inducing peptide (DSIP). Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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