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Study · Measured the body's own peptide · 1991

6 results

Peptide accretions in the endoplasmic reticulum of magnocellular neurosecretory neurons in normal and experimentally manipulated rats.

Pow DV, Morris JF, Rodgers S

Journal of anatomy1 Oct 1991Cited by 10 (Europe PMC)

PMID1810924 (opens in a new tab)PMCIDPMC1260544 (opens in a new tab)PepBankPUB-01810924
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

No result from this study comes from a test of the peptide.

Natural levels measured6

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In rat hypothalamic neurons, antibodies to oxytocin or oxytocin-associated neurophysin labelled electron-dense material in endoplasmic reticulum cisterns and neurosecretory granules.

    In plain wordsIn rats, the body's own oxytocin was found stored in dense material inside brain cells that make it.

    Peptide
    Oxytocin
    Outcome
    Not applicableOxytocin immunolabelling of intracisternal material
    Study

    ratn: not reported in source

    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    Antibodies to oxytocin or oxytocin-associated neurophysin immunolabelled the intracisternal electron-dense material and neurosecretory granules in resin-embedded ultrathin sections.
    1 context sentence
    Summary · context
    This revealed that the birefringent inclusions represented electron-dense material within cisterns of endoplasmic reticulum in magnocellular neurons.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  2. 02AnimalEndogenous levelAnimal study (in vivo)Other

    In aged rats, the number of birefringent cells with intracisternal material that holds the body's own oxytocin showed a small increase.

    In plain wordsIn aged rats, slightly more brain cells held clumps of the body's own oxytocin.

    Peptide
    Oxytocin
    Outcome
    IncreaseBirefringent oxytocin-containing cells in aged rats
    Study

    ratn: not reported in source

    Outcome group
    Aging markers · Endocrine and hormones

    Source sentences

    Summary
    Quantitation revealed a small increase in the numbers of birefringent cells in aged rats
    2 context sentences
    Summary · context
    Antibodies to oxytocin or oxytocin-associated neurophysin immunolabelled the intracisternal electron-dense material and neurosecretory granules in resin-embedded ultrathin sections.
    Summary · context
    This revealed that the birefringent inclusions represented electron-dense material within cisterns of endoplasmic reticulum in magnocellular neurons.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  3. 03AnimalEndogenous levelAnimal study (in vivo)Other

    In rats drinking saline for 3 days, the number of birefringent cells with intracisternal material that holds the body's own oxytocin showed a small increase.

    In plain wordsIn rats given saline to drink, slightly more brain cells held clumps of the body's own oxytocin.

    Peptide
    Oxytocin
    Outcome
    IncreaseBirefringent oxytocin-containing cells after saline drinking
    Study

    ratn: not reported in source

    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    Quantitation revealed a small increase in the numbers of birefringent cells in aged rats and in rats drinking saline for 3 days
    2 context sentences
    Summary · context
    Antibodies to oxytocin or oxytocin-associated neurophysin immunolabelled the intracisternal electron-dense material and neurosecretory granules in resin-embedded ultrathin sections.
    Summary · context
    This revealed that the birefringent inclusions represented electron-dense material within cisterns of endoplasmic reticulum in magnocellular neurons.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  4. 04AnimalEndogenous levelAnimal study (in vivo)Other

    In rats given subcutaneous oestradiol benzoate for 7 days, the number of birefringent cells with intracisternal material that holds the body's own oxytocin showed a large increase.

    In plain wordsIn rats given oestradiol, many more brain cells held clumps of the body's own oxytocin.

    Peptide
    Oxytocin
    Outcome
    IncreaseBirefringent oxytocin-containing cells after oestradiol benzoate
    Study

    ratn: not reported in source

    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Source sentences

    Summary
    Subcutaneous injection of oestradiol benzoate for 7 days prior to fixation caused a large increase.
    2 context sentences
    Summary · context
    Antibodies to oxytocin or oxytocin-associated neurophysin immunolabelled the intracisternal electron-dense material and neurosecretory granules in resin-embedded ultrathin sections.
    Summary · context
    This revealed that the birefringent inclusions represented electron-dense material within cisterns of endoplasmic reticulum in magnocellular neurons.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  5. 05AnimalEndogenous levelAnimal study (in vivo)Other

    In rats, the number of birefringent cells with intracisternal material that holds the body's own oxytocin decreased after oestradiol administration stopped.

    In plain wordsIn rats, fewer brain cells held clumps of the body's own oxytocin after oestradiol was stopped.

    Peptide
    Oxytocin
    Outcome
    DecreaseBirefringent oxytocin-containing cells after oestradiol cessation
    Study

    ratn: not reported in source

    Outcome group
    Sex hormones and fertility · Endocrine and hormones

    Source sentences

    Summary
    After cessation of oestradiol administration the numbers of birefringent cells decreased
    2 context sentences
    Summary · context
    Antibodies to oxytocin or oxytocin-associated neurophysin immunolabelled the intracisternal electron-dense material and neurosecretory granules in resin-embedded ultrathin sections.
    Summary · context
    This revealed that the birefringent inclusions represented electron-dense material within cisterns of endoplasmic reticulum in magnocellular neurons.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  6. 06AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In rats after oestradiol was stopped, endoplasmic reticulum cisterns in the remaining cells were frequently fused with the plasmalemma, releasing neurosecretory material directly into extracellular spaces.

    In plain wordsIn rats, brain cells holding the body's own oxytocin material released it straight out of the cell after oestradiol was stopped.

    Peptide
    Oxytocin
    Outcome
    Not applicableFusion of cisterns with plasmalemma and release of neurosecretory material
    Study

    ratn: not reported in source

    Outcome group
    Receptor activity and mechanism · Endocrine and hormones

    Source sentences

    Summary
    observations on the remaining cells showed that the endoplasmic reticulum cisterns were frequently fused with the plasmalemma, resulting in direct release of neurosecretory material into the extracellular spaces.
    2 context sentences
    Summary · context
    Antibodies to oxytocin or oxytocin-associated neurophysin immunolabelled the intracisternal electron-dense material and neurosecretory granules in resin-embedded ultrathin sections.
    Summary · context
    This revealed that the birefringent inclusions represented electron-dense material within cisterns of endoplasmic reticulum in magnocellular neurons.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:53 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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