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Study · Measured the body's own peptide · 1991

3 results

Low thymosin alpha-1 concentrations in patients chronically infected with the hepatitis B virus.

Sherman KE, Jones CC, Goldstein AL, Naylor PH

Viral immunology1 Jan 1991Cited by 18 (Europe PMC)

PMID1810323 (opens in a new tab)DOI10.1089/vim.1991.4.195 (opens in a new tab)PepBankPUB-01810323
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Natural levels measured3

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelObservational studyOther

    In patients with chronic hepatitis B, serum thymosin alpha‑1 was lower than in volunteer blood donor controls (mean 1555 versus 2159 pg/ml, P less than 0.001).

    In plain wordsIn people with chronic hepatitis B, the body's own thymosin alpha‑1 level in blood was lower than in healthy donors.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseSerum TA-1 concentration in chronic hepatitis B
    Study

    n: not reported in source

    Comparator
    Volunteer blood donor controls
    Outcome group
    Immune response · Immune and inflammation

    Measurements

    TA-1 concentration
    1555 pg/ml
    HBsAg-positive patients
    TA-1 concentration
    2159 pg/ml
    controls

    Source sentences

    Summary
    The TA-1 concentrations in HBsAg-positive patients averaged 1555 pg/ml, whereas in the control group, the mean TA-1 in serum was 2159 pg/ml (P less than 0.001).
    2 context sentences
    Summary · context
    Serum concentrations of thymosin alpha-1 (TA-1), an immunoregulatory peptide, were assayed in patients with chronic hepatitis B infection and volunteer blood donor controls.
    Summary · context
    Coded samples were tested using a radioimmunoassay.

    This result measures the body's own Thymosin alpha-1. Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelObservational studyOther

    In age- and sex-matched pairs, serum thymosin alpha‑1 was also lower in patients with chronic hepatitis B than in controls.

    In plain wordsIn matched pairs, people with chronic hepatitis B again had lower natural thymosin alpha‑1 levels than controls.

    Peptide
    Thymosin alpha-1
    Outcome
    DecreaseSerum TA-1 concentration in age- and sex-matched pairs
    Study

    n: not reported in source

    Comparator
    Age- and sex-matched controls
    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    The TA-1 concentrations in HBsAg-positive patients averaged 1555 pg/ml, whereas in the control group, the mean TA-1 in serum was 2159 pg/ml (P less than 0.001). Similar results were found for age- and sex-matched pairs.
    2 context sentences
    Summary · context
    Serum concentrations of thymosin alpha-1 (TA-1), an immunoregulatory peptide, were assayed in patients with chronic hepatitis B infection and volunteer blood donor controls.
    Summary · context
    Coded samples were tested using a radioimmunoassay.

    This result measures the body's own Thymosin alpha-1. Nobody was given the peptide. It is not evidence about taking it.

  3. 03HumanEndogenous levelObservational studyOther

    In patients with chronic hepatitis B, serum thymosin alpha‑1 was not associated with HBe antigen/antibody status or liver-associated enzymes.

    In plain wordsIn people with chronic hepatitis B, the body's own thymosin alpha‑1 level was not linked to HBe status or liver enzyme values.

    Peptide
    Thymosin alpha-1
    Outcome
    No significant changeTA-1 association with HBe status and liver enzymes
    Study

    n: not reported in source

    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    The TA-1 concentration was not associated with HBe antigen/antibody status or with values of liver-associated enzymes.
    2 context sentences
    Summary · context
    Serum concentrations of thymosin alpha-1 (TA-1), an immunoregulatory peptide, were assayed in patients with chronic hepatitis B infection and volunteer blood donor controls.
    Summary · context
    Coded samples were tested using a radioimmunoassay.

    This result measures the body's own Thymosin alpha-1. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:55 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:02 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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