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Study · Animal study (in vivo) · rabbit · 1991

2 results

Systemic absorption of oxytocin and vasopressin through eyes in rabbits.

Chiou GC, Shen ZF, Zheng YQ

Journal of ocular pharmacology1 Jan 1991Cited by 7 (Europe PMC)

PMID1809793 (opens in a new tab)DOI10.1089/jop.1991.7.351 (opens in a new tab)PepBankPUB-01809793
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Pharmacokinetics

    In rabbits, systemic absorption of oxytocin given through the eye was relatively poor.

    In plain wordsIn rabbits, little oxytocin got into the body when given as eyedrops without an absorption enhancer.

    Peptide
    Oxytocin
    Outcome
    Not applicableSystemic absorption through the eye without enhancer
    Study

    rabbitn: not reported in source

    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated · ocular (eyedrops)As given in this study (rabbit).

    Source sentences

    Summary
    their absorptions were relatively poor.
    1 context sentence
    Summary · context
    In order to avoid injections, oxytocin and vasopressin were systemically administered through ocular route.
  2. 02AnimalAnimal study (in vivo)Pharmacokinetics

    In rabbits, adding 0.5% Brij-78 as an absorption enhancer markedly increased systemic absorption of oxytocin given through the eye.

    In plain wordsIn rabbits, adding an absorption enhancer to oxytocin eyedrops greatly raised the amount that entered the body.

    Peptide
    Oxytocin
    Outcome
    IncreaseSystemic absorption through the eye with Brij-78
    Study

    rabbitn: not reported in source

    Comparator
    Eyedrops without Brij-78
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated · ocular (eyedrops)As given in this study (rabbit).

    Source sentences

    Summary
    The systemic absorption of these peptides through eyes was markedly enhanced by the addition of an absorption enhancer, 0.5% Brij-78 (polyoxyethylene-20-stearyl ether), in the eyedrops of these peptides.
    1 context sentence
    Summary · context
    In order to avoid injections, oxytocin and vasopressin were systemically administered through ocular route.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:52 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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