Mechanical properties and biochemical composition of rat cortical femur and tibia after long-term treatment with biosynthetic human growth hormone.

Jørgensen PH, Bak B, Andreassen TT

Bone1 Jan 1991Cited by 56 (Europe PMC)

PMID1782103DOI10.1016/8756-3282(91)90022-bPepBankPUB-01782103

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats, six femur and tibia mechanical properties showed positive linear relationships with b-hGH dose.
In plain wordsIn rats, six measures of bone mechanical strength increased with b-hGH dose.
Peptide
HGH (somatotropin)
Outcome
IncreaseFemur and tibia mechanical properties versus dose
Study
ratn: not reported in source
female rats
Outcome group
Bone and joint · Musculoskeletal
Studied dose
0.16, 1.10, or 8.33 mg/kg body weight/day · 90 daysAs given in this study (rat).
Source sentences
Summary
In both femur and tibia a positive linear relation was found between the dose of hormone and ultimate load, ultimate stiffness, energy absorption at ultimate load, load at failure, energy absorption at failure, and deflection at failure.
1 context sentence(design, population, supporting numbers)
Summary · context
The influence of biosynthetic human growth hormone (b-hGH) on female rat cortical femur and tibia was studied after administration of hormone doses of 0.16, 1.10, or 8.33 mg/kg body weight/day for 90 days.
Report a problemFND-0178210301
02AnimalAnimal study (in vivo)Efficacy outcome
In rats, femur deflection at ultimate load correlated positively with b-hGH dose.
In plain wordsIn rats, femur bending at maximum load increased with b-hGH dose.
Peptide
HGH (somatotropin)
Outcome
IncreaseFemur deflection at ultimate load
Study
ratn: not reported in source
female rats
Outcome group
Bone and joint · Musculoskeletal
Studied dose
0.16, 1.10, or 8.33 mg/kg body weight/day · 90 daysAs given in this study (rat).
Source sentences
Summary
In the femur a positive correlation between dose and deflection at ultimate load was also found.
1 context sentence(design, population, supporting numbers)
Summary · context
The influence of biosynthetic human growth hormone (b-hGH) on female rat cortical femur and tibia was studied after administration of hormone doses of 0.16, 1.10, or 8.33 mg/kg body weight/day for 90 days.
Report a problemFND-0178210302
03AnimalAnimal study (in vivo)Efficacy outcome
In rats, dimension-normalized mechanical properties did not differ between b-hGH and placebo, except femoral elastic modulus at the highest dose.
In plain wordsIn rats, bone mechanical properties adjusted for size were similar with b-hGH and placebo, except femoral elastic modulus at the highest dose.
Peptide
HGH (somatotropin)
Outcome
No significant changeDimension-normalized mechanical properties
Study
ratn: not reported in source
female rats
Comparator
Placebo
Outcome group
Bone and joint · Musculoskeletal
Studied dose
0.16, 1.10, or 8.33 mg/kg body weight/day · 90 daysAs given in this study (rat).
Source sentences
Summary
After normalizing the mechanical data for the dimensions of the bones, no differences were found in the hormone treated groups compared to placebo, except for the elastic modulus (Young's modulus), which was decreased in the femur in the group given 8.33 mg b-hGH.
1 context sentence(design, population, supporting numbers)
Summary · context
The influence of biosynthetic human growth hormone (b-hGH) on female rat cortical femur and tibia was studied after administration of hormone doses of 0.16, 1.10, or 8.33 mg/kg body weight/day for 90 days.
Report a problemFND-0178210303
04AnimalAnimal study (in vivo)Efficacy outcome
In female rats, femoral elastic modulus decreased with b-hGH at 8.33 mg/kg body weight/day compared with placebo.
In plain wordsIn rats, the highest b-hGH dose reduced femoral elastic modulus compared with placebo.
Peptide
HGH (somatotropin)
Outcome
DecreaseFemoral elastic modulus
Study
ratn: not reported in source
female rats
Comparator
Placebo
Outcome group
Bone and joint · Musculoskeletal
Studied dose
8.33 mg/kg body weight/day · 90 daysAs given in this study (rat).
Source sentences
Summary
After normalizing the mechanical data for the dimensions of the bones, no differences were found in the hormone treated groups compared to placebo, except for the elastic modulus (Young's modulus), which was decreased in the femur in the group given 8.33 mg b-hGH.
1 context sentence(design, population, supporting numbers)
Summary · context
The influence of biosynthetic human growth hormone (b-hGH) on female rat cortical femur and tibia was studied after administration of hormone doses of 0.16, 1.10, or 8.33 mg/kg body weight/day for 90 days.
Report a problemFND-0178210304
05AnimalAnimal study (in vivo)Efficacy outcome
In rats, b-hGH did not affect mineral concentration in femur or tibia.
In plain wordsIn rats, b-hGH did not change mineral concentration in femur or tibia.
Peptide
HGH (somatotropin)
Outcome
No significant changeMineral concentration
Study
ratn: not reported in source
female rats
Outcome group
Bone and joint · Musculoskeletal
Studied dose
0.16, 1.10, or 8.33 mg/kg body weight/day · 90 daysAs given in this study (rat).
Source sentences
Summary
The mineral and collagen concentration were unaffected in both femur and tibia, whereas the real density was decreased in the femur.
1 context sentence(design, population, supporting numbers)
Summary · context
The influence of biosynthetic human growth hormone (b-hGH) on female rat cortical femur and tibia was studied after administration of hormone doses of 0.16, 1.10, or 8.33 mg/kg body weight/day for 90 days.
Report a problemFND-0178210305
06AnimalAnimal study (in vivo)Efficacy outcome
In rats, b-hGH did not affect collagen concentration in femur or tibia.
In plain wordsIn rats, b-hGH did not change collagen concentration in femur or tibia.
Peptide
HGH (somatotropin)
Outcome
No significant changeCollagen concentration
Study
ratn: not reported in source
female rats
Outcome group
Bone and joint · Musculoskeletal
Studied dose
0.16, 1.10, or 8.33 mg/kg body weight/day · 90 daysAs given in this study (rat).
Source sentences
Summary
The mineral and collagen concentration were unaffected in both femur and tibia, whereas the real density was decreased in the femur.
1 context sentence(design, population, supporting numbers)
Summary · context
The influence of biosynthetic human growth hormone (b-hGH) on female rat cortical femur and tibia was studied after administration of hormone doses of 0.16, 1.10, or 8.33 mg/kg body weight/day for 90 days.
Report a problemFND-0178210306
07AnimalAnimal study (in vivo)Efficacy outcome
In rats, femur real density decreased after b-hGH treatment.
In plain wordsIn rats, femur density decreased after b-hGH treatment.
Peptide
HGH (somatotropin)
Outcome
DecreaseFemur real density
Study
ratn: not reported in source
female rats
Outcome group
Bone and joint · Musculoskeletal
Studied dose
0.16, 1.10, or 8.33 mg/kg body weight/day · 90 daysAs given in this study (rat).
Source sentences
Summary
The mineral and collagen concentration were unaffected in both femur and tibia, whereas the real density was decreased in the femur.
1 context sentence(design, population, supporting numbers)
Summary · context
The influence of biosynthetic human growth hormone (b-hGH) on female rat cortical femur and tibia was studied after administration of hormone doses of 0.16, 1.10, or 8.33 mg/kg body weight/day for 90 days.
Report a problemFND-0178210307

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
28 Oct 2026, 02:03 UTC
Study results updated
Version 1
27 Oct 2026, 16:37 UTC
First added · source update from Europe PMC

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