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Study · Measured the body's own peptide · 1991

5 results

Mating alters topography and content of oxytocin immunoreactivity in male mouse brain.

Jirikowski GF, Caldwell JD, Häussler HU, Pedersen CA

Cell and tissue research1 Nov 1991Cited by 16 (Europe PMC)

PMID1764731 (opens in a new tab)DOI10.1007/bf00318196 (opens in a new tab)PepBankPUB-01764731
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Natural levels measured5

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01AnimalEndogenous levelAnimal study (in vivo)Other

    In male mice that had mated once, fewer oxytocin-immunoreactive neurons were seen in the paraventricular, supraoptic and periventricular nuclei than in naive males.

    In plain wordsIn male mice, the body's own oxytocin-containing neurons were fewer in some brain areas after one mating than in unmated males.

    Peptide
    Oxytocin
    Outcome
    DecreaseOxytocin-immunoreactive neurons after one mating
    Study

    mousen: not reported in source

    Comparator
    Naive males
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    In males that had mated once, less oxytocin-immunoreactive neurons were observed in the paraventricular (PVN), supraoptic (SON) and periventricular (NPE) nuclei than in naive males.
    1 context sentence
    Summary · context
    In the present study we used radioimmunoassays of microdissected forebrain regions and immunocytochemical analysis of Vibratome sections to study the oxytocin systems of naive males, males killed after one mating, and males mated daily with different receptive females for 3 weeks.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  2. 02AnimalEndogenous levelAnimal study (in vivo)Other

    In male mice mated daily for 3 weeks, the number and staining intensity of oxytocin-immunoreactive neurons were increased in the paraventricular, supraoptic and periventricular nuclei.

    In plain wordsIn male mice, the body's own oxytocin-containing neurons were more numerous and stained more strongly in some brain areas after repeated mating.

    Peptide
    Oxytocin
    Outcome
    IncreaseOxytocin-immunoreactive neurons after repeated mating
    Study

    mousen: not reported in source

    Comparator
    Naive males
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    However, after repeated matings, the number of immunoreactive neurons and their staining intensity was increased in these regions.
    1 context sentence
    Summary · context
    In the present study we used radioimmunoassays of microdissected forebrain regions and immunocytochemical analysis of Vibratome sections to study the oxytocin systems of naive males, males killed after one mating, and males mated daily with different receptive females for 3 weeks.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  3. 03AnimalEndogenous levelAnimal study (in vivo)Other

    In repeatedly mated male mice, additional oxytocinergic neurons appeared in the lateral subcommissural nucleus, the zona incerta and the ansa lenticularis, where they were rare in unmated males.

    In plain wordsIn male mice, repeated mating was linked to the body's own oxytocin neurons appearing in extra brain areas.

    Peptide
    Oxytocin
    Outcome
    IncreaseAdditional oxytocinergic neurons in other nuclei after repeated mating
    Study

    mousen: not reported in source

    Comparator
    Naive males
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    Furthermore, additional oxytocinergic neurons could be found in the lateral subcommissural nucleus, the zona incerta and the ansa lenticularis of repeatedly mated males. Oxytocin-immunoreactive neurons were only occasionally seen in these areas in unmated males or in animals that had been killed after initial mating.
    1 context sentence
    Summary · context
    In the present study we used radioimmunoassays of microdissected forebrain regions and immunocytochemical analysis of Vibratome sections to study the oxytocin systems of naive males, males killed after one mating, and males mated daily with different receptive females for 3 weeks.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  4. 04AnimalEndogenous levelAnimal study (in vivo)Other

    Radioimmunoassay of microdissected PVN, SON, NPE and lateral hypothalamus confirmed a reduction in oxytocin-immunoreactive levels after a first mating.

    In plain wordsIn male mice, a lab assay confirmed lower oxytocin levels in some brain areas after one mating.

    Peptide
    Oxytocin
    Outcome
    DecreaseOxytocin immunoreactive level by radioimmunoassay after first mating
    Study

    mousen: not reported in source

    Comparator
    Naive males
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    Radioimmunoassays of microdissected PVN, SON, NPE and the lateral hypothalamus confirmed the reduction in oxytocin-immunoreactive levels after a first mating by a male
    1 context sentence
    Summary · context
    In the present study we used radioimmunoassays of microdissected forebrain regions and immunocytochemical analysis of Vibratome sections to study the oxytocin systems of naive males, males killed after one mating, and males mated daily with different receptive females for 3 weeks.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  5. 05AnimalEndogenous levelAnimal study (in vivo)Other

    Radioimmunoassay of microdissected PVN, SON, NPE and lateral hypothalamus confirmed an increase in oxytocin-immunoreactive levels after repeated matings.

    In plain wordsIn male mice, a lab assay confirmed higher oxytocin levels in some brain areas after repeated mating.

    Peptide
    Oxytocin
    Outcome
    IncreaseOxytocin immunoreactive level by radioimmunoassay after repeated mating
    Study

    mousen: not reported in source

    Comparator
    Naive males
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    Radioimmunoassays of microdissected PVN, SON, NPE and the lateral hypothalamus confirmed the reduction in oxytocin-immunoreactive levels after a first mating by a male and the increase after repeated matings.
    1 context sentence
    Summary · context
    In the present study we used radioimmunoassays of microdissected forebrain regions and immunocytochemical analysis of Vibratome sections to study the oxytocin systems of naive males, males killed after one mating, and males mated daily with different receptive females for 3 weeks.

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:52 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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