Skip to content

Study · Ex vivo tissue · rat · 1991

4 results

[Fetal thymus and thymuline stimulate the in vitro proliferation of oogonia in the fetal rat ovary].

Prepin J

Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie1 Jan 1991Cited by 3 (Europe PMC)

PMID1756414 (opens in a new tab)PepBankPUB-01756414
Publisher pageAsk about this study
Jump to 4 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueEfficacy outcome

    In fetal rat ovarian explants, thymulin-supplemented medium increased germ cell numbers compared with synthetic medium.

    In plain wordsIn lab tests, fetal rat ovaries cultured with thymulin had more germ cells than ovaries in synthetic medium.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseOvarian germ cell number
    Study

    ratn: not reported in source

    Fetal rat ovarian explants
    Comparator
    Synthetic medium
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · up to 6 daysAs given in this study (rat).

    Source sentences

    Summary
    In rat ovaries explanted on day 13.5 p.c. and cultured in vitro for up to 6 days, the number of germ cells is enhanced in thymulin-supplemented medium and/or after co-culture of the ovarian explants with foetal thymic tissue compared to ovaries cultured in synthetic medium.

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 02LabEndogenous levelEx vivo tissueMechanism

    In fetal rat thymic tissue cultures, corticosterone prevented thymulin secretion.

    In plain wordsIn lab tests, corticosterone prevented natural thymulin release from fetal rat thymic tissue.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    DecreaseThymulin secretion with corticosterone
    Study

    ratn: not reported in source

    Fetal rat thymic tissue cultures
    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Source sentences

    Summary
    Corticosterone added to the medium prevents the secretion of thymulin by the foetal thymus and in that condition the thymus does not influence the proliferation of oogonia.

    This result measures the body's own Thymulin (serum thymic factor). Nobody was given the peptide. It is not evidence about taking it.

Studies that did not test the peptide alone2

In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymulin (serum thymic factor).

  1. 03LabNot a test of Thymulin (serum thymic factor) aloneEx vivo tissueEfficacy outcome

    In fetal rat ovarian explants, co-culture with fetal thymic tissue increased germ cell numbers compared with synthetic medium.

    In plain wordsIn lab tests, fetal rat ovaries cultured with thymic tissue had more germ cells than ovaries in synthetic medium.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    IncreaseGerm cell number with thymic tissue
    Study

    ratn: not reported in source

    Fetal rat ovarian explants
    Comparator
    Synthetic medium
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    In rat ovaries explanted on day 13.5 p.c. and cultured in vitro for up to 6 days, the number of germ cells is enhanced in thymulin-supplemented medium and/or after co-culture of the ovarian explants with foetal thymic tissue compared to ovaries cultured in synthetic medium.

    In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).

  2. 04LabNot a test of Thymulin (serum thymic factor) aloneEx vivo tissueEfficacy outcome

    In fetal rat ovarian cultures with corticosterone, thymic tissue did not influence oogonia proliferation when thymulin secretion was prevented.

    In plain wordsIn lab tests, thymic tissue did not change rat egg precursor multiplication when corticosterone prevented thymulin release.

    Peptide
    Thymulin (serum thymic factor)
    Outcome
    No significant changeOogonia proliferation with corticosterone
    Study

    ratn: not reported in source

    Fetal rat ovarian explants
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    Corticosterone added to the medium prevents the secretion of thymulin by the foetal thymus and in that condition the thymus does not influence the proliferation of oogonia.

    In this study, Thymulin (serum thymic factor) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymulin (serum thymic factor).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 2

    21 Oct 2026, 13:55 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.