Calcitonin in phantom limb pain: a double-blind study.

Jaeger H, Maier C

Pain1 Jan 1992Cited by 84 (Europe PMC)

PMID1738570DOI10.1016/0304-3959(92)90127-wPepBankPUB-01738570

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. 7 results from people.

01HumanNon-randomized trialEfficacy outcome
In recent amputees, s-CT reduced median phantom limb pain from 7 to 4 (P less than 0.001), while placebo did not change scores.
In plain wordsIn recent amputees, s-CT reduced phantom limb pain, while placebo did not change pain scores.
Peptide
Calcitonin-salmon
Outcome
DecreasePhantom limb pain score
Study
n = 21
Comparator
Placebo
Outcome group
Pain · Nervous system and cognition
Studied dose
200 IU · infusionAs given in this study (human).
Measurements
Median phantom limb pain, NAS
7 NAS
before s-CT infusion
Median phantom limb pain, NAS
4 NAS
after s-CT infusion
Median phantom limb pain, NAS
7 NAS
after placebo
Source sentences
Summary
Using s-CT infusion, PLP was eased from a median of 7 to 4 on NAS in both groups (P less than 0.001), regardless of whether s-CT or placebo was given first. Placebo, however, did not change pain scores (median 7 on NAS, P greater than 0.1).
1 context sentence(design, population, supporting numbers)
Summary · context
To evaluate these findings a double-blind crossover comparison of s-CT treatment versus placebo was initiated. Twenty-one out of 161 patients who had undergone major amputations and developed severe PLP 0-7 days after surgery were included in the study. For each patient a matched pair of infusions w…
Report a problemFND-0173857001
02HumanNon-randomized trialEfficacy outcome
In recent amputees, 4 s-CT recipients remained pain free without a second infusion, unlike placebo recipients.
In plain wordsIn recent amputees, four s-CT recipients remained pain free without another infusion, unlike placebo recipients.
Peptide
Calcitonin-salmon
Outcome
IncreasePain freedom without second infusion
Study
n = 21
Comparator
Placebo
Outcome group
Pain · Nervous system and cognition
Studied dose
200 IU · infusionAs given in this study (human).
Measurements
Individuals pain free without a second infusion
4 individuals
s-CT group
Source sentences
Summary
In the s-CT group, but not in the placebo group, 4 individuals remained pain free without a second infusion.
1 context sentence(design, population, supporting numbers)
Summary · context
To evaluate these findings a double-blind crossover comparison of s-CT treatment versus placebo was initiated. Twenty-one out of 161 patients who had undergone major amputations and developed severe PLP 0-7 days after surgery were included in the study. For each patient a matched pair of infusions w…
Report a problemFND-0173857002
03HumanNon-randomized trialEfficacy outcome
In recent amputees treated with s-CT, 19 patients (90%) had pain relief greater than 50% one week after initial treatment.
In plain wordsIn recent amputees treated with s-CT, most patients had pain relief greater than 50% after one week.
Peptide
Calcitonin-salmon
Outcome
DecreasePain relief greater than 50%
Study
n = 21
Outcome group
Pain · Nervous system and cognition
Studied dose
200 IU · infusion · 1 weekAs given in this study (human).
Measurements
Patients with pain relief of more than 50%
19 patients
one week after first PLP treatment
Patients with pain relief of more than 50%
90%
one week after first PLP treatment
Source sentences
Summary
One week after the first PLP treatment 19 patients (90%) had pain relief of more than 50%, 16 (76%) were completely pain free, and 15 (71%) never experienced PLP again.
2 context sentences(design, population, supporting numbers)
Summary · context
Any further treatment was performed with s-CT.
Summary · context
To evaluate these findings a double-blind crossover comparison of s-CT treatment versus placebo was initiated. Twenty-one out of 161 patients who had undergone major amputations and developed severe PLP 0-7 days after surgery were included in the study. For each patient a matched pair of infusions w…
Report a problemFND-0173857003
04HumanNon-randomized trialEfficacy outcome
In recent amputees treated with s-CT, 16 patients (76%) were completely pain free one week after initial treatment.
In plain wordsIn recent amputees treated with s-CT, 76% were completely pain free after one week.
Peptide
Calcitonin-salmon
Outcome
DecreaseComplete pain freedom
Study
n = 21
Outcome group
Pain · Nervous system and cognition
Studied dose
200 IU · infusion · 1 weekAs given in this study (human).
Measurements
Patients completely pain free
16 patients
one week after first PLP treatment
Patients completely pain free
76%
one week after first PLP treatment
Source sentences
Summary
One week after the first PLP treatment 19 patients (90%) had pain relief of more than 50%, 16 (76%) were completely pain free, and 15 (71%) never experienced PLP again.
2 context sentences(design, population, supporting numbers)
Summary · context
Any further treatment was performed with s-CT.
Summary · context
To evaluate these findings a double-blind crossover comparison of s-CT treatment versus placebo was initiated. Twenty-one out of 161 patients who had undergone major amputations and developed severe PLP 0-7 days after surgery were included in the study. For each patient a matched pair of infusions w…
Report a problemFND-0173857004
05HumanNon-randomized trialEfficacy outcome
In recent amputees treated with s-CT, 15 patients (71%) never experienced phantom limb pain again.
In plain wordsIn recent amputees treated with s-CT, 71% never experienced phantom limb pain again.
Peptide
Calcitonin-salmon
Outcome
DecreaseNo recurrent phantom limb pain
Study
n = 21
Outcome group
Pain · Nervous system and cognition
Studied dose
200 IU · infusionAs given in this study (human).
Measurements
Patients who never experienced PLP again
15 patients
after first PLP treatment
Patients who never experienced PLP again
71%
after first PLP treatment
Source sentences
Summary
One week after the first PLP treatment 19 patients (90%) had pain relief of more than 50%, 16 (76%) were completely pain free, and 15 (71%) never experienced PLP again.
2 context sentences(design, population, supporting numbers)
Summary · context
Any further treatment was performed with s-CT.
Summary · context
To evaluate these findings a double-blind crossover comparison of s-CT treatment versus placebo was initiated. Twenty-one out of 161 patients who had undergone major amputations and developed severe PLP 0-7 days after surgery were included in the study. For each patient a matched pair of infusions w…
Report a problemFND-0173857005
06HumanNon-randomized trialEfficacy outcome
Among surviving amputees after s-CT treatment, 8 of 13 patients (62%) retained more than 75% pain relief after one year.
In plain wordsAmong surviving amputees after s-CT treatment, 62% retained more than 75% pain relief after one year.
Peptide
Calcitonin-salmon
Outcome
DecreasePain relief greater than 75%
Study
n = 13
Outcome group
Pain · Nervous system and cognition
Studied dose
200 IU · infusion · 1 yearAs given in this study (human).
Measurements
Patients with more than 75% PLP relief
8 patients
one year later, 13 surviving patients
Patients with more than 75% PLP relief
62%
one year later, 13 surviving patients
Source sentences
Summary
One year later 8 out of the 13 surviving patients (62%) still had more than 75% PLP relief.
2 context sentences(design, population, supporting numbers)
Summary · context
Any further treatment was performed with s-CT.
Summary · context
To evaluate these findings a double-blind crossover comparison of s-CT treatment versus placebo was initiated. Twenty-one out of 161 patients who had undergone major amputations and developed severe PLP 0-7 days after surgery were included in the study. For each patient a matched pair of infusions w…
Report a problemFND-0173857006
07HumanNon-randomized trialEfficacy outcome
After s-CT treatment for phantom limb pain, 5 individuals (42%) had pain scores above 3 at two years.
In plain wordsAfter s-CT treatment, 42% had phantom limb pain scores above three at two years.
Peptide
Calcitonin-salmon
Outcome
Direction not reportedPain score above 3
Study
n: not reported in source
Outcome group
Pain · Nervous system and cognition
Studied dose
200 IU · infusion · 2 yearsAs given in this study (human).
Measurements
Patients with PLP above 3 on NAS
5 individuals
after 2 years
Patients with PLP above 3 on NAS
42%
after 2 years
Source sentences
Summary
After 2 years PLP exceeded 3 on NAS in 5 individuals (42%), and the remaining 12 patients presented the same PLP as after 1 year.
2 context sentences(design, population, supporting numbers)
Summary · context
Any further treatment was performed with s-CT.
Summary · context
To evaluate these findings a double-blind crossover comparison of s-CT treatment versus placebo was initiated. Twenty-one out of 161 patients who had undergone major amputations and developed severe PLP 0-7 days after surgery were included in the study. For each patient a matched pair of infusions w…
Report a problemFND-0173857007

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Version history

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Version 2Current
28 Oct 2026, 02:03 UTC
Study results updated
Version 1
27 Oct 2026, 16:35 UTC
First added · source update from Europe PMC

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