Effects of vasoactive intestinal peptide, helodermin and galanin on responses of guinea-pig lung parenchyma to histamine, acetylcholine and leukotriene D4.

Conroy DM, Samhoun MN, Piper PJ

British journal of pharmacology1 Dec 1991Cited by 3 (Europe PMC)

PMID1725762PMCIDPMC1908852DOI10.1111/j.1476-5381.1991.tb12542.xPepBankPUB-01725762

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

01LabEx vivo tissueActivity measurement
In guinea-pig lung parenchymal strips, VIP (10 nM) potently and reversibly inhibited contractions induced by leukotriene D4.
In plain wordsIn lab tests on guinea-pig lung tissue, VIP strongly and reversibly reduced contractions caused by leukotriene D4.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
DecreaseLTD4-induced contraction of lung parenchymal strips
Study
guinea pign: not reported in source
Lung parenchymal strips and trachea
Outcome group
Inflammation markers · Respiratory
Studied dose
10 nMAs given in this study (guinea pig).
Source sentences
Summary
VIP (10 nM) induced a potent and reversible inhibition of the contractions of GPP induced by LTD4 (1-30 pmol)
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of vasoactive intestinal peptide (VIP) was studied on the contractile response of guinea-pig lung parenchymal strips (GPP) induced by bronchoconstrictor agonists, such as leukotriene D4 (LTD4), histamine and acetylcholine (ACh).
Report a problemFND-0172576201
02LabEx vivo tissueActivity measurement
In guinea-pig lung parenchymal strips, VIP (10 nM) did not affect contractions induced by acetylcholine.
In plain wordsIn lab tests on guinea-pig lung tissue, VIP did not change contractions caused by acetylcholine.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
No significant changeAcetylcholine-induced contraction of lung parenchymal strips
Study
guinea pign: not reported in source
Lung parenchymal strips and trachea
Outcome group
Inflammation markers · Respiratory
Studied dose
10 nMAs given in this study (guinea pig).
Source sentences
Summary
VIP (10 nM) induced a potent and reversible inhibition of the contractions of GPP induced by LTD4 (1-30 pmol) but did not affect those due to ACh (1-100 nmol) or histamine (1-30 nmol).
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of vasoactive intestinal peptide (VIP) was studied on the contractile response of guinea-pig lung parenchymal strips (GPP) induced by bronchoconstrictor agonists, such as leukotriene D4 (LTD4), histamine and acetylcholine (ACh).
Report a problemFND-0172576202
03LabEx vivo tissueActivity measurement
In guinea-pig lung parenchymal strips, VIP (10 nM) did not affect contractions induced by histamine.
In plain wordsIn lab tests on guinea-pig lung tissue, VIP did not change contractions caused by histamine.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
No significant changeHistamine-induced contraction of lung parenchymal strips
Study
guinea pign: not reported in source
Lung parenchymal strips and trachea
Outcome group
Inflammation markers · Respiratory
Studied dose
10 nMAs given in this study (guinea pig).
Source sentences
Summary
VIP (10 nM) induced a potent and reversible inhibition of the contractions of GPP induced by LTD4 (1-30 pmol) but did not affect those due to ACh (1-100 nmol) or histamine (1-30 nmol).
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of vasoactive intestinal peptide (VIP) was studied on the contractile response of guinea-pig lung parenchymal strips (GPP) induced by bronchoconstrictor agonists, such as leukotriene D4 (LTD4), histamine and acetylcholine (ACh).
Report a problemFND-0172576203
04LabEx vivo tissueActivity measurement
In guinea-pig lung parenchymal strips, VIP at 100 nM did not further inhibit leukotriene D4 responses and did not reduce responses to histamine or acetylcholine.
In plain wordsIn lab tests on guinea-pig lung tissue, ten times more VIP did not add more inhibition and did not affect histamine or acetylcholine responses.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
No significant changeContractions at tenfold higher VIP concentration
Study
guinea pign: not reported in source
Lung parenchymal strips and trachea
Outcome group
Inflammation markers · Respiratory
Studied dose
100 nMAs given in this study (guinea pig).
Source sentences
Summary
A ten fold higher concentration of VIP (100 nM) did not further inhibit LTD4-induced responses or reduce those induced by histamine or ACh.
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of vasoactive intestinal peptide (VIP) was studied on the contractile response of guinea-pig lung parenchymal strips (GPP) induced by bronchoconstrictor agonists, such as leukotriene D4 (LTD4), histamine and acetylcholine (ACh).
Report a problemFND-0172576204
05LabEx vivo tissueActivity measurement
In guinea-pig lung parenchymal strips, VIP (10 nM) significantly reduced the release of thromboxane A2 induced by leukotriene D4.
In plain wordsIn lab tests on guinea-pig lung tissue, VIP lowered the release of thromboxane A2 caused by leukotriene D4.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
DecreaseLTD4-induced thromboxane A2 release
Study
guinea pign: not reported in source
Lung parenchymal strips and trachea
Outcome group
Inflammation markers · Respiratory
Studied dose
10 nMAs given in this study (guinea pig).
Source sentences
Summary
VIP (10 nM) and helodermin (10 nM) significantly reduced the LTD4-induced release of thromboxane A2 (TXA2), measured as TxB2 by radioimmunoassay, from GPP.
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of vasoactive intestinal peptide (VIP) was studied on the contractile response of guinea-pig lung parenchymal strips (GPP) induced by bronchoconstrictor agonists, such as leukotriene D4 (LTD4), histamine and acetylcholine (ACh).
Report a problemFND-0172576205
06LabEx vivo tissueActivity measurement
In guinea-pig lung parenchymal strips, the smaller thromboxane A2 release induced by histamine was not significantly reduced in the presence of VIP.
In plain wordsIn lab tests on guinea-pig lung tissue, VIP did not significantly lower thromboxane A2 release caused by histamine.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
No significant changeHistamine-induced thromboxane A2 release
Study
guinea pign: not reported in source
Lung parenchymal strips and trachea
Outcome group
Inflammation markers · Respiratory
Studied dose
Dose not stated
Source sentences
Summary
The smaller release of TxA2 induced by histamine was not significantly reduced in the presence of VIP.
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of vasoactive intestinal peptide (VIP) was studied on the contractile response of guinea-pig lung parenchymal strips (GPP) induced by bronchoconstrictor agonists, such as leukotriene D4 (LTD4), histamine and acetylcholine (ACh).
Report a problemFND-0172576206
07LabEx vivo tissueActivity measurement
VIP at 0.1-3 nmol induced dose-related relaxations of guinea-pig trachea.
In plain wordsIn lab tests on guinea-pig windpipe, VIP relaxed the tissue in a dose-related way.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreaseRelaxation of guinea-pig trachea
Study
guinea pign: not reported in source
Lung parenchymal strips and trachea
Outcome group
Receptor activity and mechanism · Respiratory
Studied dose
0.1-3 nmolAs given in this study (guinea pig).
Source sentences
Summary
In contrast to VIP and helodermin, both at 0.1-3 nmol, which induced doserelated relaxations of guinea-pig trachea
1 context sentence(design, population, supporting numbers)
Summary · context
The effect of vasoactive intestinal peptide (VIP) was studied on the contractile response of guinea-pig lung parenchymal strips (GPP) induced by bronchoconstrictor agonists, such as leukotriene D4 (LTD4), histamine and acetylcholine (ACh).
Report a problemFND-0172576207

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
12 Oct 2026, 12:58 UTC
Study results updated
Version 1
9 Oct 2026, 12:41 UTC
First added · source update from Europe PMC

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Effects of vasoactive intestinal peptide, helodermin and galanin on responses of guinea-pig lung parenchyma to histamine, acetylcholine and leukotriene D4.

Summary

Results from this study7

Version history

Subjects

Publication types

MeSH terms