Effect of substance P/bombesin antagonists on the release of growth hormone by GHRP and GHRH.

Bitar KG, Bowers CY, Coy DH

Biochemical and biophysical research communications1 Oct 1991Cited by 16 (Europe PMC)

PMID1718273DOI10.1016/s0006-291x(05)81269-0PepBankPUB-01718273

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone4

In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking GHRP-6.

01LabNot a test of GHRP-6 aloneIn vitro (cells)Mechanism
In vitro, P-7492 dose-dependently inhibited GH release stimulated by GHRP.
In plain wordsIn lab tests, P-7492 reduced GH release stimulated by GHRP.
Peptide
GHRP-6
Outcome
DecreaseP-7492 inhibition
Study
n: not reported in source
in vitro GH release system
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Measurements
IC50
0.2 microM
P-7492
Source sentences
Summary
P-7492, P-7483, and P-7482 decreased, dose-dependently, the release of GH by GHRP (IC50 = 0.2 microM, 0.85 microM, and 6 microM, respectively).
1 context sentence(design, population, supporting numbers)
Summary · context
were tested for their in vitro effects on the release of growth hormone (GH) in the presence of GHRH and growth hormone releasing peptide, HisDTrpAlaTrpDPheLysNH2(GHRP).
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-0171827301
02LabNot a test of GHRP-6 aloneIn vitro (cells)Mechanism
In vitro, P-7483 dose-dependently inhibited GH release stimulated by GHRP.
In plain wordsIn lab tests, P-7483 reduced GH release stimulated by GHRP.
Peptide
GHRP-6
Outcome
DecreaseP-7483 inhibition
Study
n: not reported in source
in vitro GH release system
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Measurements
IC50
0.85 microM
P-7483
Source sentences
Summary
P-7492, P-7483, and P-7482 decreased, dose-dependently, the release of GH by GHRP (IC50 = 0.2 microM, 0.85 microM, and 6 microM, respectively).
1 context sentence(design, population, supporting numbers)
Summary · context
were tested for their in vitro effects on the release of growth hormone (GH) in the presence of GHRH and growth hormone releasing peptide, HisDTrpAlaTrpDPheLysNH2(GHRP).
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-0171827302
03LabNot a test of GHRP-6 aloneIn vitro (cells)Mechanism
In vitro, P-7482 dose-dependently inhibited GH release stimulated by GHRP.
In plain wordsIn lab tests, P-7482 reduced GH release stimulated by GHRP.
Peptide
GHRP-6
Outcome
DecreaseP-7482 inhibition
Study
n: not reported in source
in vitro GH release system
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Measurements
IC50
6 microM
P-7482
Source sentences
Summary
P-7492, P-7483, and P-7482 decreased, dose-dependently, the release of GH by GHRP (IC50 = 0.2 microM, 0.85 microM, and 6 microM, respectively).
1 context sentence(design, population, supporting numbers)
Summary · context
were tested for their in vitro effects on the release of growth hormone (GH) in the presence of GHRH and growth hormone releasing peptide, HisDTrpAlaTrpDPheLysNH2(GHRP).
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-0171827303
04LabNot a test of GHRP-6 aloneIn vitro (cells)Mechanism
In vitro, DC21-366 did not decrease GH release stimulated by GHRP.
In plain wordsIn lab tests, DC21-366 did not reduce GH release stimulated by GHRP.
Peptide
GHRP-6
Outcome
No significant changeDC21-366 inhibition
Study
n: not reported in source
in vitro GH release system
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Source sentences
Summary
DC21-366 decreased the stimulated release of GH by GHRH (IC50 = 0.16 microM) but not by GHRP.
1 context sentence(design, population, supporting numbers)
Summary · context
were tested for their in vitro effects on the release of growth hormone (GH) in the presence of GHRH and growth hormone releasing peptide, HisDTrpAlaTrpDPheLysNH2(GHRP).
In this study, GHRP-6 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking GHRP-6.
Report a problemFND-0171827304

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:59 UTC
Study results updated
Version 1
9 Oct 2026, 03:13 UTC
First added · source update from Europe PMC

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