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Study · Animal study (in vivo) · rat · 1991

6 results

[The delta sleep-inducing peptide as a factor enhancing the content of substance P in the hypothalamus and the resistance of rats to emotional stress].

Salieva RM, Ianovskiĭ K, Ratsak R, Trofimova IaI, Oehme P, Sudakov KV, Iumatov EA

Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova1 May 1991Cited by 1 (Europe PMC)

PMID1718095 (opens in a new tab)PepBankPUB-01718095
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In male rats, DSIP significantly increased the mean substance P content in the hypothalamus.

    In plain wordsIn male rats, DSIP raised substance P content in the hypothalamus.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseMean substance P content in hypothalamus
    Study

    ratn: not reported in source

    Outcome group
    Stress hormones · Nervous system and cognition
    Studied dose
    60 and 120 nmol/kg · intraperitoneallyAs given in this study (rat).

    Source sentences

    Summary
    DSIP administration significantly increased the mean SP content in the hypothalamus
    1 context sentence
    Summary · context
    The influence of the delta-sleep inducing peptide (DSIP, 60 and 120 nmol/kg, intraperitoneally) on the content of substance P (SP) in rats hypothalamus was studied on males of August line.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In male rats, DSIP also increased substance P content in the hypothalamus of animals stable and predisposed to emotional stress.

    In plain wordsIn male rats, DSIP raised hypothalamic substance P in animals that resist stress and in animals prone to it.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseSubstance P content in hypothalamus of stress-stable and stress-predisposed animals
    Study

    ratn: not reported in source

    Outcome group
    Stress hormones · Nervous system and cognition
    Studied dose
    60 and 120 nmol/kg · intraperitoneallyAs given in this study (rat).

    Source sentences

    Summary
    DSIP administration significantly increased the mean SP content in the hypothalamus and also its content in animals, stable and predisposed to emotional stress.
    1 context sentence
    Summary · context
    The influence of the delta-sleep inducing peptide (DSIP, 60 and 120 nmol/kg, intraperitoneally) on the content of substance P (SP) in rats hypothalamus was studied on males of August line.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats under emotional stress, daily DSIP given before stress increased the substance P content in the hypothalamus that stress had decreased.

    In plain wordsIn stressed rats, daily DSIP raised hypothalamic substance P that stress had lowered.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseHypothalamic substance P after daily DSIP before emotional stress
    Study

    ratn: not reported in source

    Outcome group
    Stress hormones · Nervous system and cognition
    Studied dose
    60 and 120 nmol/kg · intraperitoneallyAs given in this study (rat).

    Source sentences

    Summary
    Daily DSIP administration before putting the rats in conditions of stress increased the SP content in the hypothalamus decreased at the emotional stress.
    1 context sentence
    Summary · context
    The influence of the delta-sleep inducing peptide (DSIP, 60 and 120 nmol/kg, intraperitoneally) on the content of substance P (SP) in rats hypothalamus was studied on males of August line.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats subjected to stress, a preliminary single DSIP administration also increased substance P content.

    In plain wordsIn stressed rats, one earlier dose of DSIP also raised substance P content.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseHypothalamic substance P after single DSIP in stressed animals
    Study

    ratn: not reported in source

    Outcome group
    Stress hormones · Nervous system and cognition
    Studied dose
    60 and 120 nmol/kg · intraperitoneallyAs given in this study (rat).

    Source sentences

    Summary
    Preliminary single DSIP administration to the animals subjected to stress also increased the SP content.
    1 context sentence
    Summary · context
    The influence of the delta-sleep inducing peptide (DSIP, 60 and 120 nmol/kg, intraperitoneally) on the content of substance P (SP) in rats hypothalamus was studied on males of August line.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats under emotional stress, a single DSIP dose of 60 nmol/kg sharply reduced adrenal hypertrophy.

    In plain wordsIn stressed rats, one DSIP dose sharply reduced enlargement of the adrenal glands.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseAdrenal hypertrophy under emotional stress
    Study

    ratn: not reported in source

    Outcome group
    Stress hormones · Nervous system and cognition
    Studied dose
    60 nmol/kg · intraperitoneallyAs given in this study (rat).

    Source sentences

    Summary
    Single DSIP administration in a dose of 60 nmol/kg sharply reduced classical stress manifestations, such as hypertrophy of adrenals and thymus involution.
    1 context sentence
    Summary · context
    The influence of the delta-sleep inducing peptide (DSIP, 60 and 120 nmol/kg, intraperitoneally) on the content of substance P (SP) in rats hypothalamus was studied on males of August line.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In rats under emotional stress, a single DSIP dose of 60 nmol/kg sharply reduced thymus involution.

    In plain wordsIn stressed rats, one DSIP dose sharply reduced shrinking of the thymus.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseThymus involution under emotional stress
    Study

    ratn: not reported in source

    Outcome group
    Stress hormones · Nervous system and cognition
    Studied dose
    60 nmol/kg · intraperitoneallyAs given in this study (rat).

    Source sentences

    Summary
    Single DSIP administration in a dose of 60 nmol/kg sharply reduced classical stress manifestations, such as hypertrophy of adrenals and thymus involution.
    1 context sentence
    Summary · context
    The influence of the delta-sleep inducing peptide (DSIP, 60 and 120 nmol/kg, intraperitoneally) on the content of substance P (SP) in rats hypothalamus was studied on males of August line.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 17:28 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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