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Study · Ex vivo tissue · helix pomatia · 1991

6 results

Influence of oxytocin on integration of postsynaptic potentials in molluscan neurons.

Dyatlov VA

Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology1 Jan 1991

PMID1712690 (opens in a new tab)DOI10.1016/0742-8413(91)90203-6 (opens in a new tab)PepBankPUB-01712690
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueMechanism

    In molluscan neurons, 10-minute exposure to 10(-8) M oxytocin had no effect on the resting membranes.

    In plain wordsIn snail neurons, oxytocin did not change the resting state of the cell membrane.

    Peptide
    Oxytocin
    Outcome
    No significant changeResting membrane effect of oxytocin
    Study

    Helix pomatian: not reported in source

    Perioesophageal ganglionic ring with buccal ganglia
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    10(-8) M · 10 minutesAs given in this study (Helix pomatia).

    Source sentences

    Summary
    Ten minute exposure to 10(-8) M OXT had no effects on the resting membranes
    1 context sentence
    Summary · context
    Intracellular recordings were made from identified and non-identified neurons in perioesophageal ganglionic ring with buccal ganglia of the mollusc, Helix pomatia.
  2. 02LabEx vivo tissueMechanism

    In molluscan neurons, oxytocin enhanced the amplitude of excitatory postsynaptic potentials.

    In plain wordsIn snail neurons, oxytocin made the incoming nerve signals larger.

    Peptide
    Oxytocin
    Outcome
    IncreaseExcitatory postsynaptic potential amplitude
    Study

    Helix pomatian: not reported in source

    Perioesophageal ganglionic ring with buccal ganglia
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    10(-8) M · 10 minutesAs given in this study (Helix pomatia).

    Source sentences

    Summary
    Ten minute exposure to 10(-8) M OXT had no effects on the resting membranes, but triggered secondary mechanisms, which lead to enhancement of the excitatory PSP (EPSR) amplitudes
  3. 03LabEx vivo tissueMechanism

    In molluscan neurons, oxytocin decreased the decay time constant of the excitatory postsynaptic potential.

    In plain wordsIn snail neurons, oxytocin made the incoming nerve signals fade faster.

    Peptide
    Oxytocin
    Outcome
    DecreaseDecay time constant of the excitatory postsynaptic potential
    Study

    Helix pomatian: not reported in source

    Perioesophageal ganglionic ring with buccal ganglia
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    10(-8) M · 10 minutesAs given in this study (Helix pomatia).

    Source sentences

    Summary
    Ten minute exposure to 10(-8) M OXT had no effects on the resting membranes, but triggered secondary mechanisms, which lead to enhancement of the excitatory PSP (EPSR) amplitudes and the decrease of the decay time constant (tau EPSR) obtained from the falling phase of the EPSP
  4. 04LabEx vivo tissueMechanism

    In molluscan neurons, after oxytocin the enhanced EPSP amplitude evoked action potentials under space summation and made them easier under temporal summation.

    In plain wordsIn snail neurons, oxytocin made it easier for combined nerve signals to trigger a nerve impulse.

    Peptide
    Oxytocin
    Outcome
    IncreaseAction potential appearance under summation of EPSPs
    Study

    Helix pomatian: not reported in source

    Perioesophageal ganglionic ring with buccal ganglia
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    10(-8) M · 10 minutesAs given in this study (Helix pomatia).

    Source sentences

    Summary
    The enhancement of the EPSP amplitude and the decrease of tau EPSP after OXT application evoked the appearance of action potential under space summation of two spontaneous EPSPs and made easier the appearance of action potential under temporal summation of EPSPs produced by paired afferent stimuli,…
    1 context sentence
    Summary · context
    Intracellular recordings were made from identified and non-identified neurons in perioesophageal ganglionic ring with buccal ganglia of the mollusc, Helix pomatia.
  5. 05LabEx vivo tissueMechanism

    In neuron E5, oxytocin made the integrated amplitude of the excitatory acetylcholine response and the inhibitory dopamine response more positive when the interval between applications was short.

    In plain wordsIn one snail neuron, oxytocin changed how acetylcholine and dopamine signals added up when they came close together.

    Peptide
    Oxytocin
    Outcome
    IncreaseIntegrated acetylcholine and dopamine responses in neuron E5
    Study

    Helix pomatian: not reported in source

    Perioesophageal ganglionic ring with buccal ganglia
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    10(-8) M · 10 minutesAs given in this study (Helix pomatia).

    Source sentences

    Summary
    Ten minute exposure to 10(-8) M OXT made the integrated amplitude of the excitatory acetylcholine response and the inhibitory dopamine response in the neuron E5 more positive only when the interval between applications of these mediators was smaller than the time constant of desensitization of acety…
    1 context sentence
    Summary · context
    Intracellular recordings were made from identified and non-identified neurons in perioesophageal ganglionic ring with buccal ganglia of the mollusc, Helix pomatia.

Studies that did not test the peptide alone1

In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Oxytocin.

  1. 06LabNot a test of Oxytocin aloneEx vivo tissueMechanism

    In the investigated molluscan neurons, drugs that elevate intracellular cyclic AMP mimicked the influence of oxytocin on integration of postsynaptic potentials.

    In plain wordsIn snail neurons, drugs that raise cyclic AMP copied the effect that oxytocin had on how signals add up.

    Peptide
    Oxytocin
    Outcome
    Not applicableMimicry of oxytocin effect by cAMP-elevating drugs
    Study

    Helix pomatian: not reported in source

    Perioesophageal ganglionic ring with buccal ganglia
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    The pharmacological studies showed that drugs, which elevate intracellular cyclic AMP levels, mimicked the influence of OXT on integration of PSPs in the investigated neurons.
    1 context sentence
    Summary · context
    Intracellular recordings were made from identified and non-identified neurons in perioesophageal ganglionic ring with buccal ganglia of the mollusc, Helix pomatia.

    In this study, Oxytocin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Oxytocin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:53 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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