Increased weight gain, nitrogen retention and muscle protein synthesis following treatment of diabetic rats with insulin-like growth factor (IGF)-I and des(1-3)IGF-I.

Tomas FM, Knowles SE, Owens PC, Read LC, Chandler CS, Gargosky SE, Ballard FJ

The Biochemical journal1 Jun 1991Cited by 39 (Europe PMC)

PMID1710892PMCIDPMC1151126DOI10.1042/bj2760547PepBankPUB-01710892

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In diabetic rats, des(1‑3)IGF-I produced body weight effects approximately 70% of those obtained with insulin.
In plain wordsIn rats with diabetes, des(1‑3)IGF-I produced smaller weight effects than insulin.
Peptide
IGF-1 DES (des(1-3)IGF-I)
Outcome
DecreaseBody weight
Study
ratn: not reported in source
streptozotocin-induced diabetes
Comparator
Insulin
Outcome group
Body weight · Metabolic and weight
Studied dose
1.08 mg/kg per day · infusion · 7 daysAs given in this study (rat).
Source sentences
Summary
A 2.5-fold higher IGF-I dose, or des(1-3)IGF-I at 1.08 mg/kg per day, gave effects that were approx. 70% of those obtained with insulin. hGH at 1.38 mg/kg per day was not effective.
2 context sentences(design, population, supporting numbers)
Summary · context
IGF-I at a dose of 1.05 or 1.08 mg/kg per day in two experiments increased body weight and nitrogen retention above those of vehicle-infused controls to about 30% of the improvement achieved with 25 or 30 units of insulin/kg per day, but only in the second experiment were the differences statistical…
Summary · context
We have examined the effects of infusing recombinant human growth hormone (hGH), insulin-like growth factor-I (IGF-I), the truncated IGF-I analogue, des(1-3)IGF-I, and insulin over a 7-day period in streptozotocin-induced diabetic rats.
Report a problemFND-0171089201
02AnimalAnimal study (in vivo)Efficacy outcome
In diabetic rats, des(1‑3)IGF-I produced nitrogen retention effects approximately 70% of those obtained with insulin.
In plain wordsIn rats with diabetes, des(1‑3)IGF-I produced smaller nitrogen retention effects than insulin.
Peptide
IGF-1 DES (des(1-3)IGF-I)
Outcome
DecreaseNitrogen retention
Study
ratn: not reported in source
streptozotocin-induced diabetes
Comparator
Insulin
Outcome group
Muscle injury and repair · Musculoskeletal
Studied dose
1.08 mg/kg per day · infusion · 7 daysAs given in this study (rat).
Source sentences
Summary
A 2.5-fold higher IGF-I dose, or des(1-3)IGF-I at 1.08 mg/kg per day, gave effects that were approx. 70% of those obtained with insulin. hGH at 1.38 mg/kg per day was not effective.
2 context sentences(design, population, supporting numbers)
Summary · context
IGF-I at a dose of 1.05 or 1.08 mg/kg per day in two experiments increased body weight and nitrogen retention above those of vehicle-infused controls to about 30% of the improvement achieved with 25 or 30 units of insulin/kg per day, but only in the second experiment were the differences statistical…
Summary · context
We have examined the effects of infusing recombinant human growth hormone (hGH), insulin-like growth factor-I (IGF-I), the truncated IGF-I analogue, des(1-3)IGF-I, and insulin over a 7-day period in streptozotocin-induced diabetic rats.
Report a problemFND-0171089202
03AnimalAnimal study (in vivo)Efficacy outcome
In diabetic rats, IGF peptides including des(1‑3)IGF-I did not ameliorate glucosuria.
In plain wordsIn rats with diabetes, des(1‑3)IGF-I did not improve glucose loss in urine.
Peptide
IGF-1 DES (des(1-3)IGF-I)
Outcome
No significant changeGlucosuria
Study
ratn: not reported in source
streptozotocin-induced diabetes
Outcome group
Glycemic control · Metabolic and weight
Studied dose
1.08 mg/kg per day · infusion · 7 daysAs given in this study (rat).
Source sentences
Summary
The IGF peptides, unlike insulin, did not ameliorate the diabetic glucosuria.
1 context sentence(design, population, supporting numbers)
Summary · context
We have examined the effects of infusing recombinant human growth hormone (hGH), insulin-like growth factor-I (IGF-I), the truncated IGF-I analogue, des(1-3)IGF-I, and insulin over a 7-day period in streptozotocin-induced diabetic rats.
Report a problemFND-0171089203
04AnimalAnimal study (in vivo)Mechanism
In diabetic rats, increased muscle protein synthesis partly accounted for improved nitrogen balance with IGF peptides.
In plain wordsIn rats with diabetes, IGF peptides increased muscle protein production, which partly explained improved nitrogen balance.
Peptide
IGF-1 DES (des(1-3)IGF-I)
Outcome
IncreaseMuscle protein synthesis
Study
ratn: not reported in source
streptozotocin-induced diabetes
Outcome group
Muscle injury and repair · Musculoskeletal
Studied dose
1.08 mg/kg per day · infusion · 7 daysAs given in this study (rat).
Source sentences
Summary
The improvements in nitrogen balance could be accounted for in part by increases in muscle protein synthesis.
1 context sentence(design, population, supporting numbers)
Summary · context
We have examined the effects of infusing recombinant human growth hormone (hGH), insulin-like growth factor-I (IGF-I), the truncated IGF-I analogue, des(1-3)IGF-I, and insulin over a 7-day period in streptozotocin-induced diabetic rats.
Report a problemFND-0171089204
05AnimalAnimal study (in vivo)Efficacy outcome
In diabetic rats, IGF peptides including des(1‑3)IGF-I did not inhibit muscle protein breakdown.
In plain wordsIn rats with diabetes, des(1‑3)IGF-I did not reduce muscle protein breakdown.
Peptide
IGF-1 DES (des(1-3)IGF-I)
Outcome
No significant changeMuscle protein breakdown
Study
ratn: not reported in source
streptozotocin-induced diabetes
Outcome group
Muscle injury and repair · Musculoskeletal
Studied dose
1.08 mg/kg per day · infusion · 7 daysAs given in this study (rat).
Source sentences
Summary
Muscle protein breakdown, as assessed by 3-methylhistidine excretion, was inhibited by insulin, but not by the IGF peptides.
1 context sentence(design, population, supporting numbers)
Summary · context
We have examined the effects of infusing recombinant human growth hormone (hGH), insulin-like growth factor-I (IGF-I), the truncated IGF-I analogue, des(1-3)IGF-I, and insulin over a 7-day period in streptozotocin-induced diabetic rats.
Report a problemFND-0171089205
06AnimalAnimal study (in vivo)Efficacy outcome
In diabetic rats, IGF peptides did not produce the carcass fat increase observed with insulin.
In plain wordsIn rats with diabetes, IGF peptides did not increase body fat as insulin did.
Peptide
IGF-1 DES (des(1-3)IGF-I)
Outcome
No significant changeCarcass fat
Study
ratn: not reported in source
streptozotocin-induced diabetes
Outcome group
Body weight · Metabolic and weight
Studied dose
1.08 mg/kg per day · infusion · 7 daysAs given in this study (rat).
Source sentences
Summary
This did not occur with the IGF peptides, suggesting that IGF predominantly stimulates the growth of lean tissue.
2 context sentences(design, population, supporting numbers)
Summary · context
Carcass fat increased substantially following insulin administration.
Summary · context
We have examined the effects of infusing recombinant human growth hormone (hGH), insulin-like growth factor-I (IGF-I), the truncated IGF-I analogue, des(1-3)IGF-I, and insulin over a 7-day period in streptozotocin-induced diabetic rats.
Report a problemFND-0171089206
07AnimalAnimal study (in vivo)Mechanism
In diabetic rats, des(1‑3)IGF-I induced IGF-binding proteins.
In plain wordsIn rats with diabetes, des(1‑3)IGF-I increased IGF-binding proteins.
Peptide
IGF-1 DES (des(1-3)IGF-I)
Outcome
IncreaseIGF-binding proteins
Study
ratn: not reported in source
streptozotocin-induced diabetes
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
1.08 mg/kg per day · infusion · 7 daysAs given in this study (rat).
Source sentences
Summary
Des(1-3)IGF-I induced binding proteins, but had only a slight effect on measured IGF-I concentrations.
1 context sentence(design, population, supporting numbers)
Summary · context
We have examined the effects of infusing recombinant human growth hormone (hGH), insulin-like growth factor-I (IGF-I), the truncated IGF-I analogue, des(1-3)IGF-I, and insulin over a 7-day period in streptozotocin-induced diabetic rats.
Report a problemFND-0171089207
08AnimalAnimal study (in vivo)Mechanism
In diabetic rats, des(1‑3)IGF-I had only a slight effect on measured IGF-I concentrations.
In plain wordsIn rats with diabetes, des(1‑3)IGF-I changed measured IGF-I levels only slightly.
Peptide
IGF-1 DES (des(1-3)IGF-I)
Outcome
Direction not reportedMeasured IGF-I concentrations
Study
ratn: not reported in source
streptozotocin-induced diabetes
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
1.08 mg/kg per day · infusion · 7 daysAs given in this study (rat).
Source sentences
Summary
Des(1-3)IGF-I induced binding proteins, but had only a slight effect on measured IGF-I concentrations.
1 context sentence(design, population, supporting numbers)
Summary · context
We have examined the effects of infusing recombinant human growth hormone (hGH), insulin-like growth factor-I (IGF-I), the truncated IGF-I analogue, des(1-3)IGF-I, and insulin over a 7-day period in streptozotocin-induced diabetic rats.
Report a problemFND-0171089208

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 3Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 2
21 Oct 2026, 13:52 UTC
Study data updated · source update from Europe PMC
Version 1
21 Oct 2026, 12:50 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.