Distribution and actions of galanin and vasoactive intestinal peptide in the human colon.

Burleigh DE, Furness JB

Neuropeptides1 Jun 1990Cited by 20 (Europe PMC)

PMID1701228DOI10.1016/0143-4179(90)90115-fPepBankPUB-01701228

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

2 results from studies that gave the peptide. No result from this study comes from people.

01LabEx vivo tissueEfficacy outcome
In human sigmoid colon muscle strips, VIP relaxed both circular and longitudinal muscle.
In plain wordsIn lab tests on human colon muscle strips, VIP relaxed both muscle layers.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
IncreaseRelaxation of circular and longitudinal colonic muscle strips
Study
humann: not reported in source
muscularis externa strips, human sigmoid colon
Outcome group
Gastrointestinal motility · Gastrointestinal
Studied dose
Dose not stated
Source sentences
Summary
Circular and longitudinal muscle strips were contracted by GAL and relaxed by VIP.
1 context sentence(design, population, supporting numbers)
Summary · context
Responses to galanin (GAL) and vasoactive intestinal peptide (VIP) and their distribution were investigated in muscularis externa from the human sigmoid colon.
Report a problemFND-0170122801
02LabEx vivo tissueEfficacy outcome
In human sigmoid colon muscle strips, longitudinal muscle was less sensitive to VIP than circular muscle.
In plain wordsIn lab tests on human colon muscle strips, the longitudinal layer responded less to VIP than the circular layer.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
Not applicableSensitivity of muscle layers to VIP
Study
humann: not reported in source
muscularis externa strips, human sigmoid colon
Comparator
Circular muscle
Outcome group
Gastrointestinal motility · Gastrointestinal
Studied dose
Dose not stated
Source sentences
Summary
There was a marked difference in sensitivity between muscle layers to both peptides; circular muscle being less sensitive to GAL, longitudinal muscle less sensitive to VIP.
1 context sentence(design, population, supporting numbers)
Summary · context
Responses to galanin (GAL) and vasoactive intestinal peptide (VIP) and their distribution were investigated in muscularis externa from the human sigmoid colon.
Report a problemFND-0170122802

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

03LabEndogenous levelEx vivo tissueOther
In human sigmoid colon, VIP immunoreactivity was found in nerve fibres supplying both muscle layers and in the myenteric ganglia.
In plain wordsIn human colon tissue, the body's own VIP was found in nerve fibres of both muscle layers and in nerve ganglia.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
Not applicableLocation of VIP immunoreactivity in the colon
Study
humann: not reported in source
muscularis externa strips, human sigmoid colon
Outcome group
Endogenous peptide levels · Gastrointestinal
Source sentences
Summary
Immunohistochemical studies revealed GAL-like immunoreactivity (GAL-IR) and VIP-IR in nerve fibres supplying both muscle layers as well as the myenteric ganglia.
1 context sentence(design, population, supporting numbers)
Summary · context
Responses to galanin (GAL) and vasoactive intestinal peptide (VIP) and their distribution were investigated in muscularis externa from the human sigmoid colon.
This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0170122804
04LabEndogenous levelEx vivo tissueOther
In human sigmoid colon, galanin immunoreactivity co-existed with VIP immunoreactivity in many nerve fibres of the circular and longitudinal muscle layers.
In plain wordsIn human colon tissue, the body's own VIP and galanin were often found in the same nerve fibres.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
Not applicableCo-localization of VIP and galanin immunoreactivity
Study
humann: not reported in source
muscularis externa strips, human sigmoid colon
Outcome group
Endogenous peptide levels · Gastrointestinal
Source sentences
Summary
Additionally GAL-IR was shown to co-exist with VIP-IR in many nerve fibres innervating human circular and longitudinal (taenial) colonic muscle layers.
1 context sentence(design, population, supporting numbers)
Summary · context
Responses to galanin (GAL) and vasoactive intestinal peptide (VIP) and their distribution were investigated in muscularis externa from the human sigmoid colon.
This result measures the body's own Vasoactive intestinal peptide (VIP, aviptadil). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-0170122805

Studies that did not test the peptide alone1

In this study, Vasoactive intestinal peptide (VIP, aviptadil) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Vasoactive intestinal peptide (VIP, aviptadil).

05LabNot a test of Vasoactive intestinal peptide (VIP, aviptadil) aloneEx vivo tissueEfficacy outcome
In human sigmoid colon longitudinal muscle strips, galanin given at the same time attenuated the response to VIP.
In plain wordsIn lab tests on human colon muscle strips, galanin given together with VIP weakened the response to VIP.
Peptide
Vasoactive intestinal peptide (VIP, aviptadil)
Outcome
DecreaseVIP response of longitudinal muscle with galanin
Study
humann: not reported in source
muscularis externa strips, human sigmoid colon
Outcome group
Gastrointestinal motility · Gastrointestinal
Source sentences
Summary
When given simultaneously GAL attenuated responses to VIP on longitudinal muscle
1 context sentence(design, population, supporting numbers)
Summary · context
Responses to galanin (GAL) and vasoactive intestinal peptide (VIP) and their distribution were investigated in muscularis externa from the human sigmoid colon.
In this study, Vasoactive intestinal peptide (VIP, aviptadil) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Vasoactive intestinal peptide (VIP, aviptadil).
Report a problemFND-0170122803

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
12 Oct 2026, 12:58 UTC
Study results updated
Version 1
9 Oct 2026, 12:41 UTC
First added · source update from Europe PMC

Subjects

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