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Study · Measured the body's own peptide · 1990

3 results

Peptides and transmitter enzymes in hypothalamic magnocellular neurons after administration of hyperosmotic stimuli: comparison between messenger RNA and peptide/protein levels.

Meister B, Cortés R, Villar MJ, Schalling M, Hökfelt T

Cell and tissue research1 May 1990Cited by 124 (Europe PMC)

PMID1694105 (opens in a new tab)DOI10.1007/bf00318631 (opens in a new tab)PepBankPUB-01694105
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Natural levels measured3

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01AnimalEndogenous levelAnimal study (in vivo)Other

    In rats, prolonged salt loading increased oxytocin mRNA levels in the paraventricular and supraoptic nuclei.

    In plain wordsIn rats, a high salt diet raised the activity of the gene for the body's own oxytocin in two brain areas.

    Peptide
    Oxytocin
    Outcome
    IncreaseOxytocin mRNA in PVN and SON after salt loading
    Study

    ratn: not reported in source

    salt-loaded rats, PVN and SON magnocellular neurons
    Comparator
    Control rats
    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Source sentences

    Summary
    After prolonged administration of 2% sodium chloride as drinking water (salt-loading), the treatment increased the levels of VP, OXY, TH, GAL, DYN and CCK mRNA in the PVN and SON.
    1 context sentence
    Summary · context
    In situ hybridization histochemistry and indirect immunofluorescence histochemistry were used to study changes in the expression of vasopressin (VP), oxytocin (OXY), tyrosine hydroxylase (TH), galanin (GAL), dynorphin (DYN) and cholecystokinin (CCK) in hypothalamic magnocellular neurons of the parav…

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  2. 02AnimalEndogenous levelAnimal study (in vivo)Other

    In salt-loaded rats, oxytocin-like immunoreactivity was depleted within cell bodies of the paraventricular and supraoptic nuclei.

    In plain wordsIn rats on a high salt diet, the body's own oxytocin stored in brain cell bodies fell.

    Peptide
    Oxytocin
    Outcome
    DecreaseOxytocin-like immunoreactivity in PVN and SON cell bodies
    Study

    ratn: not reported in source

    salt-loaded rats, PVN and SON magnocellular neurons
    Comparator
    Control rats
    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Source sentences

    Summary
    Within cell bodies of the PVN and SON of salt-loaded rats, a depletion of VP- and OXY-like immunoreactivity (LI)
    1 context sentence
    Summary · context
    In situ hybridization histochemistry and indirect immunofluorescence histochemistry were used to study changes in the expression of vasopressin (VP), oxytocin (OXY), tyrosine hydroxylase (TH), galanin (GAL), dynorphin (DYN) and cholecystokinin (CCK) in hypothalamic magnocellular neurons of the parav…

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

  3. 03AnimalEndogenous levelAnimal study (in vivo)Other

    In salt-loaded rats, oxytocin-like immunoreactivity in posterior pituitary nerve fibers was depleted, less strongly than vasopressin.

    In plain wordsIn rats on a high salt diet, the body's own oxytocin in pituitary nerve fibers fell, less than vasopressin.

    Peptide
    Oxytocin
    Outcome
    DecreaseOxytocin-like immunoreactivity in posterior pituitary nerve fibers
    Study

    ratn: not reported in source

    salt-loaded rats, PVN and SON magnocellular neurons
    Comparator
    Control rats
    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Source sentences

    Summary
    Within nerve fibers of the posterior pituitary of salt-loaded rats, a marked depletion of VP-, GAL- and DYN-LI was found. Less pronounced depletion was observed in OXY- and CCK-LI, and no specific changes in TH-LI were seen.
    1 context sentence
    Summary · context
    In situ hybridization histochemistry and indirect immunofluorescence histochemistry were used to study changes in the expression of vasopressin (VP), oxytocin (OXY), tyrosine hydroxylase (TH), galanin (GAL), dynorphin (DYN) and cholecystokinin (CCK) in hypothalamic magnocellular neurons of the parav…

    This result measures the body's own Oxytocin. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 20:03 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:54 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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