MIF-1 potentiates the action of tricyclic antidepressants in an animal model of depression.

Kostowski W, Danysz W, Dyr W, Jankowska E, Krzaścik P, Pałejko W, Stefański R, Płaźnik A

Peptides1 Sept 1991Cited by 15 (Europe PMC)

PMID1686934DOI10.1016/0196-9781(91)90037-pPepBankPUB-01686934

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

4 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats, MIF‑1 stimulated active behavior in the forced swim test in a dose-dependent manner.
In plain wordsIn rats, MIF‑1 increased active behavior in a swim test as the dose changed.
Peptide
MIF-1 (Pro-Leu-Gly-NH2)
Outcome
IncreaseActive forced-swim behavior
Study
ratn: not reported in source
Forced swim test
Outcome group
Anxiety and mood · Mental health and mood
Studied dose
Dose not stated
Source sentences
Summary
It was found that MIF-1 stimulated in a dose-dependent manner "active" behavior of animals in this paradigm.
1 context sentence(design, population, supporting numbers)
Summary · context
In the present paper, the effect of simultaneous treatment of rats with low doses of MIF-1 and tricyclic antidepressants on rat behavior in the forced swim test was studied.
Report a problemFND-0168693401
02AnimalAnimal study (in vivo)Mechanism
In rats, the MIF‑1 behavioral effect appeared independent of locomotor changes in the open field test.
In plain wordsIn rats, the MIF‑1 swim-test effect appeared independent of movement changes in an open field test.
Peptide
MIF-1 (Pro-Leu-Gly-NH2)
Outcome
Not applicableLocomotor relationship
Study
ratn: not reported in source
Forced swim and open field tests
Outcome group
Anxiety and mood · Mental health and mood
Studied dose
Dose not stated
Source sentences
Summary
The effect of MIF-1 appeared to be independent of changes in rats' locomotion in the open field test.
1 context sentence(design, population, supporting numbers)
Summary · context
In the present paper, the effect of simultaneous treatment of rats with low doses of MIF-1 and tricyclic antidepressants on rat behavior in the forced swim test was studied.
Report a problemFND-0168693402
03AnimalAnimal study (in vivo)Efficacy outcome
In rats, MIF‑1 plus amitriptyline stimulated active forced-swim behavior more than amitriptyline alone.
In plain wordsIn rats, adding MIF‑1 to amitriptyline increased active swim-test behavior more than amitriptyline alone.
Peptide
MIF-1 (Pro-Leu-Gly-NH2)
Outcome
IncreaseActive behavior with amitriptyline versus amitriptyline alone
Study
ratn: not reported in source
Forced swim test
Comparator
Amitriptyline alone
Outcome group
Anxiety and mood · Mental health and mood
Studied dose
0.01 mg/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
The combined treatment of rats with MIF-1 (0.01 mg/kg IP) and amitriptyline (5 mg/kg IP) or desipramine (1.25 mg/kg) IP) significantly stimulated active behavior in the forced swim test above the level obtained with each of the drugs given separately.
1 context sentence(design, population, supporting numbers)
Summary · context
In the present paper, the effect of simultaneous treatment of rats with low doses of MIF-1 and tricyclic antidepressants on rat behavior in the forced swim test was studied.
Report a problemFND-0168693403
04AnimalAnimal study (in vivo)Efficacy outcome
In rats, MIF‑1 plus desipramine stimulated active forced-swim behavior more than desipramine alone.
In plain wordsIn rats, adding MIF‑1 to desipramine increased active swim-test behavior more than desipramine alone.
Peptide
MIF-1 (Pro-Leu-Gly-NH2)
Outcome
IncreaseActive behavior with desipramine versus desipramine alone
Study
ratn: not reported in source
Forced swim test
Comparator
Desipramine alone
Outcome group
Anxiety and mood · Mental health and mood
Studied dose
0.01 mg/kg · intraperitonealAs given in this study (rat).
Source sentences
Summary
The combined treatment of rats with MIF-1 (0.01 mg/kg IP) and amitriptyline (5 mg/kg IP) or desipramine (1.25 mg/kg) IP) significantly stimulated active behavior in the forced swim test above the level obtained with each of the drugs given separately.
1 context sentence(design, population, supporting numbers)
Summary · context
In the present paper, the effect of simultaneous treatment of rats with low doses of MIF-1 and tricyclic antidepressants on rat behavior in the forced swim test was studied.
Report a problemFND-0168693405

Studies that did not test the peptide alone2

In this study, MIF-1 (Pro-Leu-Gly-NH2) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking MIF-1 (Pro-Leu-Gly-NH2).

05AnimalNot a test of MIF-1 (Pro-Leu-Gly-NH2) aloneAnimal study (in vivo)Efficacy outcome
In rats, MIF‑1 plus amitriptyline stimulated active forced-swim behavior more than MIF‑1 alone.
In plain wordsIn rats, MIF‑1 plus amitriptyline increased active swim-test behavior more than MIF‑1 alone.
Peptide
MIF-1 (Pro-Leu-Gly-NH2)
Outcome
IncreaseActive behavior with amitriptyline versus MIF-1 alone
Study
ratn: not reported in source
Forced swim test
Comparator
MIF-1 alone
Outcome group
Anxiety and mood · Mental health and mood
Source sentences
Summary
The combined treatment of rats with MIF-1 (0.01 mg/kg IP) and amitriptyline (5 mg/kg IP) or desipramine (1.25 mg/kg) IP) significantly stimulated active behavior in the forced swim test above the level obtained with each of the drugs given separately.
1 context sentence(design, population, supporting numbers)
Summary · context
In the present paper, the effect of simultaneous treatment of rats with low doses of MIF-1 and tricyclic antidepressants on rat behavior in the forced swim test was studied.
In this study, MIF-1 (Pro-Leu-Gly-NH2) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MIF-1 (Pro-Leu-Gly-NH2).
Report a problemFND-0168693404
06AnimalNot a test of MIF-1 (Pro-Leu-Gly-NH2) aloneAnimal study (in vivo)Efficacy outcome
In rats, MIF‑1 plus desipramine stimulated active forced-swim behavior more than MIF‑1 alone.
In plain wordsIn rats, MIF‑1 plus desipramine increased active swim-test behavior more than MIF‑1 alone.
Peptide
MIF-1 (Pro-Leu-Gly-NH2)
Outcome
IncreaseActive behavior with desipramine versus MIF-1 alone
Study
ratn: not reported in source
Forced swim test
Comparator
MIF-1 alone
Outcome group
Anxiety and mood · Mental health and mood
Source sentences
Summary
The combined treatment of rats with MIF-1 (0.01 mg/kg IP) and amitriptyline (5 mg/kg IP) or desipramine (1.25 mg/kg) IP) significantly stimulated active behavior in the forced swim test above the level obtained with each of the drugs given separately.
1 context sentence(design, population, supporting numbers)
Summary · context
In the present paper, the effect of simultaneous treatment of rats with low doses of MIF-1 and tricyclic antidepressants on rat behavior in the forced swim test was studied.
In this study, MIF-1 (Pro-Leu-Gly-NH2) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MIF-1 (Pro-Leu-Gly-NH2).
Report a problemFND-0168693406

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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MeSH terms

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