Effects of melanostatine (MIF-1) on focal potentials in slices of rat brain cortex.

Mokrushin AA, Emelyanov NA

Neuropeptides1 Oct 1991Cited by 3 (Europe PMC)

PMID1686794DOI10.1016/0143-4179(91)90057-pPepBankPUB-01686794

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

01LabEx vivo tissueActivity measurement
In rat olfactory cortex slices, MIF‑1 initially depressed focal potential amplitudes, followed by restoration and prolonged enhancement.
In plain wordsIn lab tests with rat brain slices, MIF‑1 first reduced olfactory electrical responses, then increased them.
Peptide
MIF-1 (Pro-Leu-Gly-NH2)
Outcome
MixedOlfactory focal potential amplitude
Study
ratn: not reported in source
Rat olfactory and parietal cortex slices
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
10(-7)-10(-5) M · perfusionAs given in this study (rat).
Measurements
Enhancement duration
30 to 40 min
olfactory focal potential amplitudes
Source sentences
Summary
The addition of MIF-1 to perfusion fluid caused in olfactory cortex the primary depression of FP amplitudes
2 context sentences(design, population, supporting numbers)
Summary · context
this depression was replaced by restoration and prolonged (30-40 min) enhancement of FP amplitudes
Summary · context
The effects of tripeptide melanostatine (Melano-Inhibitory Factor--MIF-1) in concentrations 10(-7)-10(-5) M on parameters of focal potentials (FPs) were studied in slices of rat olfactory and parietal cortex.
Report a problemFND-0168679401
02LabEx vivo tissueActivity measurement
In rat olfactory cortex slices, MIF‑1 produced additional focal potential components, including disynaptic EPSPs and IPSPs.
In plain wordsIn lab tests with rat brain slices, MIF‑1 produced additional excitatory and inhibitory electrical response components.
Peptide
MIF-1 (Pro-Leu-Gly-NH2)
Outcome
IncreaseAdditional focal potential components
Study
ratn: not reported in source
Rat olfactory and parietal cortex slices
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
10(-7)-10(-5) M · perfusionAs given in this study (rat).
Source sentences
Summary
this depression was replaced by restoration and prolonged (30-40 min) enhancement of FP amplitudes and by appearance of additional FP components, such as disynaptic EPSPs and IPSPs.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of tripeptide melanostatine (Melano-Inhibitory Factor--MIF-1) in concentrations 10(-7)-10(-5) M on parameters of focal potentials (FPs) were studied in slices of rat olfactory and parietal cortex.
Report a problemFND-0168679402
03LabEx vivo tissueActivity measurement
In rat parietal cortex slices, MIF‑1 increased focal potential amplitudes evoked by stimulation of adjoining points.
In plain wordsIn lab tests with rat brain slices, MIF‑1 increased parietal electrical response amplitudes.
Peptide
MIF-1 (Pro-Leu-Gly-NH2)
Outcome
IncreaseParietal focal potential amplitude
Study
ratn: not reported in source
Rat olfactory and parietal cortex slices
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
10(-7)-10(-5) M · perfusionAs given in this study (rat).
Source sentences
Summary
In parietal cortex slices MIF-1 caused the elevation of FP amplitudes evoked by stimulating adjoining points.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of tripeptide melanostatine (Melano-Inhibitory Factor--MIF-1) in concentrations 10(-7)-10(-5) M on parameters of focal potentials (FPs) were studied in slices of rat olfactory and parietal cortex.
Report a problemFND-0168679403
04LabEx vivo tissueActivity measurement
In rat cortex slices, repeated MIF‑1 perfusion potentiated its effect on focal potential amplitude increases.
In plain wordsIn lab tests with rat brain slices, repeated MIF‑1 exposure strengthened its increase in electrical response amplitudes.
Peptide
MIF-1 (Pro-Leu-Gly-NH2)
Outcome
IncreaseRepeated perfusion potentiation
Study
ratn: not reported in source
Rat olfactory and parietal cortex slices
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
10(-7)-10(-5) M · perfusionAs given in this study (rat).
Source sentences
Summary
The repetitive perfusion of slices with MIF-1 potentiated the peptide effect on the increase of FP amplitudes.
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of tripeptide melanostatine (Melano-Inhibitory Factor--MIF-1) in concentrations 10(-7)-10(-5) M on parameters of focal potentials (FPs) were studied in slices of rat olfactory and parietal cortex.
Report a problemFND-0168679404
05LabEx vivo tissueActivity measurement
In rat olfactory cortex slices, MIF‑1 facilitated induction of post-tetanic potentiation during the excitatory period.
In plain wordsIn lab tests with rat brain slices, MIF‑1 helped initiate enhanced electrical responses after repeated stimulation.
Peptide
MIF-1 (Pro-Leu-Gly-NH2)
Outcome
IncreasePost-tetanic potentiation induction
Study
ratn: not reported in source
Rat olfactory and parietal cortex slices
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
10(-7)-10(-5) M · perfusionAs given in this study (rat).
Source sentences
Summary
During excitatory period MIF-1 influenced specifically the functional plasticity in olfactory cortex, having facilitated the induction and sustaining of post-tetanic potentiation (PTP).
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of tripeptide melanostatine (Melano-Inhibitory Factor--MIF-1) in concentrations 10(-7)-10(-5) M on parameters of focal potentials (FPs) were studied in slices of rat olfactory and parietal cortex.
Report a problemFND-0168679405
06LabEx vivo tissueActivity measurement
In rat olfactory cortex slices, MIF‑1 facilitated maintenance of post-tetanic potentiation during the excitatory period.
In plain wordsIn lab tests with rat brain slices, MIF‑1 helped sustain enhanced electrical responses after repeated stimulation.
Peptide
MIF-1 (Pro-Leu-Gly-NH2)
Outcome
IncreasePost-tetanic potentiation maintenance
Study
ratn: not reported in source
Rat olfactory and parietal cortex slices
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
10(-7)-10(-5) M · perfusionAs given in this study (rat).
Source sentences
Summary
During excitatory period MIF-1 influenced specifically the functional plasticity in olfactory cortex, having facilitated the induction and sustaining of post-tetanic potentiation (PTP).
1 context sentence(design, population, supporting numbers)
Summary · context
The effects of tripeptide melanostatine (Melano-Inhibitory Factor--MIF-1) in concentrations 10(-7)-10(-5) M on parameters of focal potentials (FPs) were studied in slices of rat olfactory and parietal cortex.
Report a problemFND-0168679406

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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