Skip to content

Study · Animal study (in vivo) · rat · 1991

5 results

Effects of the oxytocin fragment prolyl-leucyl-glycinamide on sexual behavior in the rat.

Gorzalka BB, Luck KA, Tanco SA

Pharmacology, biochemistry, and behavior1 Feb 1991Cited by 5 (Europe PMC)

PMID1676168 (opens in a new tab)DOI10.1016/0091-3057(91)90278-a (opens in a new tab)PepBankPUB-01676168
Publisher pagePubMedAsk about this study
Jump to 5 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In female rats, PLG facilitated sexual behavior.

    In plain wordsIn female rats, PLG increased sexual behavior.

    Peptide
    MIF-1 (Pro-Leu-Gly-NH2)
    Outcome
    IncreaseFemale sexual behavior
    Study

    ratn: not reported in source

    Outcome group
    Sexual function · Reproductive and sexual health
    Studied dose
    0.1-10 mg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    PLG (0.1-10 mg/kg) was found to facilitate female sexual behavior in Experiment 1.
    1 context sentence
    Summary · context
    Morphine and/or PLG were administered intraperitoneally to male and female rats and sexual behavior was observed.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In female rats, PLG facilitation of receptivity depended on progesterone.

    In plain wordsIn female rats, PLG required progesterone to increase sexual receptivity.

    Peptide
    MIF-1 (Pro-Leu-Gly-NH2)
    Outcome
    Not applicableProgesterone dependence of female receptivity
    Study

    ratn: not reported in source

    Outcome group
    Sexual function · Reproductive and sexual health
    Studied dose
    Dose not stated · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    In Experiment 2, the ability of PLG to facilitate female receptivity was found to be progesterone dependent.
    1 context sentence
    Summary · context
    Morphine and/or PLG were administered intraperitoneally to male and female rats and sexual behavior was observed.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In male rats, PLG failed to facilitate sexual behavior.

    In plain wordsIn male rats, PLG did not increase sexual behavior.

    Peptide
    MIF-1 (Pro-Leu-Gly-NH2)
    Outcome
    No significant changeMale sexual behavior
    Study

    ratn: not reported in source

    Outcome group
    Sexual function · Reproductive and sexual health
    Studied dose
    Dose not stated · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    In Experiment 4, PLG failed to facilitate male sexual behavior.
    1 context sentence
    Summary · context
    Morphine and/or PLG were administered intraperitoneally to male and female rats and sexual behavior was observed.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In male rats, PLG did not affect morphine-induced inhibition of sexual behavior.

    In plain wordsIn male rats, PLG did not change the inhibition of sexual behavior caused by morphine.

    Peptide
    MIF-1 (Pro-Leu-Gly-NH2)
    Outcome
    No significant changeMorphine-induced inhibition of male sexual behavior
    Study

    ratn: not reported in source

    Outcome group
    Sexual function · Reproductive and sexual health
    Studied dose
    Dose not stated · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    In Experiments 5 and 6, PLG did not affect morphine-induced inhibition of either male or female sexual behavior.
    1 context sentence
    Summary · context
    Morphine and/or PLG were administered intraperitoneally to male and female rats and sexual behavior was observed.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In female rats, PLG did not affect morphine-induced inhibition of sexual behavior.

    In plain wordsIn female rats, PLG did not change the inhibition of sexual behavior caused by morphine.

    Peptide
    MIF-1 (Pro-Leu-Gly-NH2)
    Outcome
    No significant changeMorphine-induced inhibition of female sexual behavior
    Study

    ratn: not reported in source

    Outcome group
    Sexual function · Reproductive and sexual health
    Studied dose
    Dose not stated · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    In Experiments 5 and 6, PLG did not affect morphine-induced inhibition of either male or female sexual behavior.
    1 context sentence
    Summary · context
    Morphine and/or PLG were administered intraperitoneally to male and female rats and sexual behavior was observed.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 2

    21 Oct 2026, 18:59 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:52 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.