Cardiovascular and respiratory effects of dermorphin in rats.

Portolano F, Filippelli A, Marrazzo R, Susanna V, Russo S, Stella L, Losasso C, Budetta SN, Molinario L, Angrisani M

Research communications in chemical pathology and pharmacology1 Feb 1991Cited by 5 (Europe PMC)

PMID1675473PepBankPUB-01675473

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Safety outcome
In male rats, dermorphin produced arterial hypotension.
In plain wordsIn rats, dermorphin lowered arterial blood pressure.
Peptide
Dermorphin
Outcome
DecreaseArterial hypotension
Study
ratn: not reported in source
Normotensive and spontaneously hypertensive male rats
Outcome group
Blood pressure · Cardiovascular
Studied dose
Dose not stated · intravenous or intracerebroventricularAs given in this study (rat).
Source sentences
Summary
Intravenously or intracerebroventricularly administration of D produced arterial hypotension with sinus bradycardia and respiratory depression.
1 context sentence(design, population, supporting numbers)
Summary · context
The cardiovascular and respiratory effects of dermorphin (D) have been evaluated in freely moving or anesthetized normotensive and spontaneously hypertensive male rats.
Report a problemFND-0167547301
02AnimalAnimal study (in vivo)Safety outcome
In male rats, dermorphin produced sinus bradycardia.
In plain wordsIn rats, dermorphin slowed the sinus heart rhythm.
Peptide
Dermorphin
Outcome
DecreaseSinus bradycardia
Study
ratn: not reported in source
Normotensive and spontaneously hypertensive male rats
Outcome group
Heart function · Cardiovascular
Studied dose
Dose not stated · intravenous or intracerebroventricularAs given in this study (rat).
Source sentences
Summary
Intravenously or intracerebroventricularly administration of D produced arterial hypotension with sinus bradycardia and respiratory depression.
1 context sentence(design, population, supporting numbers)
Summary · context
The cardiovascular and respiratory effects of dermorphin (D) have been evaluated in freely moving or anesthetized normotensive and spontaneously hypertensive male rats.
Report a problemFND-0167547302
03AnimalAnimal study (in vivo)Safety outcome
In male rats, dermorphin produced respiratory depression.
In plain wordsIn rats, dermorphin depressed breathing.
Peptide
Dermorphin
Outcome
DecreaseRespiratory depression
Study
ratn: not reported in source
Normotensive and spontaneously hypertensive male rats
Outcome group
Adverse events · Respiratory
Studied dose
Dose not stated · intravenous or intracerebroventricularAs given in this study (rat).
Source sentences
Summary
Intravenously or intracerebroventricularly administration of D produced arterial hypotension with sinus bradycardia and respiratory depression.
1 context sentence(design, population, supporting numbers)
Summary · context
The cardiovascular and respiratory effects of dermorphin (D) have been evaluated in freely moving or anesthetized normotensive and spontaneously hypertensive male rats.
Report a problemFND-0167547303
04AnimalAnimal study (in vivo)Activity measurement
In hypertensive rats, dermorphin produced more intense cardiovascular effects than in normotensive rats.
In plain wordsIn hypertensive rats, dermorphin produced stronger cardiovascular effects than in normotensive rats.
Peptide
Dermorphin
Outcome
IncreaseCardiovascular effect intensity
Study
ratn: not reported in source
Normotensive and spontaneously hypertensive male rats
Comparator
Normotensive rats
Outcome group
Receptor activity and mechanism · Cardiovascular
Studied dose
Dose not stated · intravenous or intracerebroventricularAs given in this study (rat).
Source sentences
Summary
In hypertensive rats D produced more intense and longer cardiovascular effects than those seen in normotensive animals.
1 context sentence(design, population, supporting numbers)
Summary · context
The cardiovascular and respiratory effects of dermorphin (D) have been evaluated in freely moving or anesthetized normotensive and spontaneously hypertensive male rats.
Report a problemFND-0167547304
05AnimalAnimal study (in vivo)Activity measurement
In hypertensive rats, dermorphin produced longer cardiovascular effects than in normotensive rats.
In plain wordsIn hypertensive rats, dermorphin's cardiovascular effects lasted longer than in normotensive rats.
Peptide
Dermorphin
Outcome
IncreaseCardiovascular effect duration
Study
ratn: not reported in source
Normotensive and spontaneously hypertensive male rats
Comparator
Normotensive rats
Outcome group
Receptor activity and mechanism · Cardiovascular
Studied dose
Dose not stated · intravenous or intracerebroventricularAs given in this study (rat).
Source sentences
Summary
In hypertensive rats D produced more intense and longer cardiovascular effects than those seen in normotensive animals.
1 context sentence(design, population, supporting numbers)
Summary · context
The cardiovascular and respiratory effects of dermorphin (D) have been evaluated in freely moving or anesthetized normotensive and spontaneously hypertensive male rats.
Report a problemFND-0167547305
06AnimalAnimal study (in vivo)Mechanism
In rats, dermorphin cardiovascular responses involved mu and k opioid receptor activation.
In plain wordsIn rats, dermorphin's cardiovascular responses involved mu and k opioid receptors.
Peptide
Dermorphin
Outcome
Not applicableCardiovascular opioid receptor involvement
Study
ratn: not reported in source
Normotensive and spontaneously hypertensive male rats
Outcome group
Receptor activity and mechanism · Cardiovascular
Studied dose
Dose not stated · intravenous or intracerebroventricularAs given in this study (rat).
Source sentences
Summary
D effects involve the activation of mu and k opioid receptors for cardiovascular responses and mu 2 opioid receptors for respiratory depression without any significant effect on delta receptors.
1 context sentence(design, population, supporting numbers)
Summary · context
The cardiovascular and respiratory effects of dermorphin (D) have been evaluated in freely moving or anesthetized normotensive and spontaneously hypertensive male rats.
Report a problemFND-0167547306
07AnimalAnimal study (in vivo)Mechanism
In rats, dermorphin respiratory depression involved mu 2 opioid receptor activation without significant delta receptor effects.
In plain wordsIn rats, dermorphin's breathing depression involved mu 2 opioid receptors without significant delta receptor effects.
Peptide
Dermorphin
Outcome
Not applicableRespiratory opioid receptor involvement
Study
ratn: not reported in source
Normotensive and spontaneously hypertensive male rats
Outcome group
Receptor activity and mechanism · Respiratory
Studied dose
Dose not stated · intravenous or intracerebroventricularAs given in this study (rat).
Source sentences
Summary
D effects involve the activation of mu and k opioid receptors for cardiovascular responses and mu 2 opioid receptors for respiratory depression without any significant effect on delta receptors.
1 context sentence(design, population, supporting numbers)
Summary · context
The cardiovascular and respiratory effects of dermorphin (D) have been evaluated in freely moving or anesthetized normotensive and spontaneously hypertensive male rats.
Report a problemFND-0167547307

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
27 Oct 2026, 18:20 UTC
Study results updated
Version 1
27 Oct 2026, 16:32 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

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