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Study · Measured the body's own peptide · 1991

3 results

Neuropeptides in cerebrospinal fluid in normal-pressure hydrocephalus and dementia.

Wikkelsö C, Ekman R, Westergren I, Johansson B

European neurology1 Jan 1991Cited by 21 (Europe PMC)

PMID1675171 (opens in a new tab)DOI10.1159/000116653 (opens in a new tab)PepBankPUB-01675171
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Natural levels measured3

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelObservational studyOther

    In patients with normal-pressure hydrocephalus, cerebrospinal fluid levels of the body's own DSIP increased significantly after the shunt operation, in parallel with clinical improvement.

    In plain wordsIn patients with hydrocephalus, the body's own DSIP in spinal fluid rose after shunt surgery, together with clinical improvement.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    IncreaseCSF DSIP after shunt operation in NPH
    Study

    n = 10

    Outcome group
    Endogenous peptide levels · Nervous system and cognition

    Source sentences

    Summary
    The concentration of DSIP, VIP and SOM increased significantly in parallel to the clinical improvement after the shunt operation in NPH patients.
    1 context sentence
    Summary · context
    Delta-sleep-inducing peptide (DSIP), vasoactive intestinal peptide (VIP), peptide YY (PYY) and somatostatin (SOM) were assayed with specific radioimmunological methods in cerebrospinal fluid (CSF) of healthy volunteers, 12 patients with Alzheimer's disease (AD), 11 patients with multi-infarct dement…

    This result measures the body's own Delta sleep-inducing peptide (DSIP). Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelObservational studyOther

    In patients with normal-pressure hydrocephalus, cerebrospinal fluid levels of the body's own DSIP were lower than in controls.

    In plain wordsLower levels of the body's own DSIP in spinal fluid were linked to normal-pressure hydrocephalus compared with healthy controls.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    DecreaseCSF DSIP in normal-pressure hydrocephalus versus controls
    Study

    n: not reported in source

    Comparator
    Healthy controls
    Outcome group
    Endogenous peptide levels · Nervous system and cognition

    Source sentences

    Summary
    DSIP, PYY and SOM levels in CSF were decreased in patients with NPH compared to controls.
    1 context sentence
    Summary · context
    Delta-sleep-inducing peptide (DSIP), vasoactive intestinal peptide (VIP), peptide YY (PYY) and somatostatin (SOM) were assayed with specific radioimmunological methods in cerebrospinal fluid (CSF) of healthy volunteers, 12 patients with Alzheimer's disease (AD), 11 patients with multi-infarct dement…

    This result measures the body's own Delta sleep-inducing peptide (DSIP). Nobody was given the peptide. It is not evidence about taking it.

  3. 03HumanEndogenous levelObservational studyOther

    In patients with Alzheimer's disease, multi-infarct dementia and normal-pressure hydrocephalus, CSF concentrations of the peptides, DSIP included, did not correlate with the degree of dementia.

    In plain wordsIn patients with dementia or hydrocephalus, the body's own DSIP in spinal fluid was not linked to how severe the dementia was.

    Peptide
    Delta sleep-inducing peptide (DSIP)
    Outcome
    No significant changeCorrelation of CSF peptide levels with degree of dementia
    Study

    n: not reported in source

    Outcome group
    Endogenous peptide levels · Nervous system and cognition

    Source sentences

    Summary
    No correlations were found between the degree of dementia in any of the illnesses and the CSF concentrations of the peptides.
    1 context sentence
    Summary · context
    Delta-sleep-inducing peptide (DSIP), vasoactive intestinal peptide (VIP), peptide YY (PYY) and somatostatin (SOM) were assayed with specific radioimmunological methods in cerebrospinal fluid (CSF) of healthy volunteers, 12 patients with Alzheimer's disease (AD), 11 patients with multi-infarct dement…

    This result measures the body's own Delta sleep-inducing peptide (DSIP). Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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